Alkaloid leonurine exerts anti‐inflammatory effects via modulating MST1 expression in trophoblast cells

Zong, Fang; Zhao, Yulin

doi:10.1002/iid3.493

Cited by 7 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MST1, part of the tumor necrosis factor (TNF-α) receptor 1 signaling complex, reduces the effect of TNF-α on NFκB signaling. Leonurine (LNR) is one of the active components of motherwort 135 , which can exert anti-inflammatory and anti-apoptotic effects by upregulating MST1 and inhibiting NFκB signaling 136 137 . MMP-1 can encourage the release of IL-8 from vascular smooth muscle, and it is markedly enhanced in the PE circulation.…”

Section: Nfκb Pathway: Targets For Drug Therapy In Pementioning

confidence: 99%

The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia

Li,

Zhu,

et al. 2024

Geburtshilfe Frauenheilkd

View full text Add to dashboard Cite

The high prevalence of preeclampsia (PE) is a major cause of maternal and fetal mortality and affects the long-term prognosis of both mother and baby. Termination of pregnancy is currently the only effective treatment for PE, so there is an urgent need for research into its pathogenesis and the development of new therapeutic approaches. The NFκB family of transcription factors has an essential role in inflammation and innate immunity. In this review, we summarize the role of NFκB in normal and preeclampsia pregnancies, the role of NFκB in existing treatment strategies, and potential NFκB treatment strategies.

show abstract

Section: Nfκb Pathway: Targets For Drug Therapy In Pementioning

confidence: 99%

The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia

Li,

Zhu,

et al. 2024

Geburtshilfe Frauenheilkd

View full text Add to dashboard Cite

show abstract

“…Leo's anti-neoplastic influence is exerted through the "Leo-microRNA-TRAIL" interaction, a mechanism indicative of Leo's significant potential in the design of clinical oncological therapeutics (Zong and Zhao, 2021;.…”

Section: Leo Activates Tumor Necrosis Factorrelated Apoptosis-inducin...mentioning

confidence: 99%

New Mechanisms for Anti-Cancer Drugs

2024

Frontiers Research Topics

View full text Add to dashboard Cite

Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

show abstract

“…Leo’s anti-neoplastic influence is exerted through the “Leo-microRNA-TRAIL” interaction, a mechanism indicative of Leo’s significant potential in the design of clinical oncological therapeutics ( Zong and Zhao, 2021 ; Han et al, 2022 ).…”

Section: Tumor Cellular Signaling Pathways and Mechanisms Affected By...mentioning

confidence: 99%

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

Cao,

Wang,

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Leonurine refers to the desiccated aerial portion of a plant in the Labiatae family. The primary bioactive constituent of Leonurine is an alkaloid, Leonurine alkaloid (Leo), renowned for its substantial therapeutic efficacy in the treatment of gynecological disorders, in addition to its broad-spectrum antineoplastic capabilities. Over recent years, the pharmacodynamic mechanisms of Leo have garnered escalating scholarly interest. Leo exhibits its anticancer potential by means of an array of mechanisms, encompassing the inhibition of neoplastic cell proliferation, induction of both apoptosis and autophagy, and the containment of oncogenic cell invasion and migration. The key signal transduction pathways implicated in these processes include the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), the Phosphoinositide3-Kinase/Serine/Threonine Protein Kinase (PI3K/AKT), the Signal Transducer and Activator of Transcription 3 (STAT3), and the Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase (MAP/ERK). This paper commences with an exploration of the principal oncogenic cellular behaviors influenced by Leo and the associated signal transduction pathways, thereby scrutinizing the mechanisms of Leo in the antineoplastic sequence of events. The intention is to offer theoretical reinforcement for the elucidation of more profound mechanisms underpinning Leo’s anticancer potential and correlating pharmaceutical development.

show abstract

Alkaloid leonurine exerts anti‐inflammatory effects via modulating MST1 expression in trophoblast cells

Cited by 7 publications

References 28 publications

The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia

The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia

New Mechanisms for Anti-Cancer Drugs

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

Contact Info

Product

Resources

About