Alkaloid Content of the Leaves of Three Nbigerian Datura Species

Nuhu, H; Ghani, Abdul

doi:10.4314/njnpm.v6i1.11685

Cited by 12 publications

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“…Although H. muticus has been known to have antifungal activity (Tolba and El-Hissy 1972), it is not clear whether TAs are relevant to the activity. Several papers revealed that Datura metel containing TAs (Nuhu and Ghani 2002), also has antifungal potential (Dabur et al 2004;Sharma 2002;Shafique and Shafique 2008). Some fungal species can grow even in the presence of alkaloids or secondary metabolites of host plants (Hol and van Veen 2002;Ishimoto et al 2000), suggesting that fungi associated with plants may be tolerant to antifungal compounds produced by the plants.…”

Section: Abbreviationmentioning

confidence: 97%

responses of fungi to tropane alkaloids produced by a medicinal plant Hyoscyamus muticus (Egyptian Henbane)

et al. 2009

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Antifungal activity of hyoscyamine (Hcy) and scopolamine (Sco) were determined by TLC-bioautography against fungi associated with H. muticus grown in Egypt, and those isolated from other plants grown in Japan. All 40 fungal strains were tolerant to Sco and sensitive to Hcy, exhibiting a growth inhibition zone around the Hcy spot on the bioautography plate. The strains were grouped into three types based on the appearance of the inhibition zone: (i) 17 strains exhibiting a clear inhibition zone, which remained clear at 8 d after incubation (type I); (ii) 22 strains exhibiting the inhibition zone with a brown circle surrounding the zone and regrowth within the inhibition zone (type II); (iii) 1 strain exhibiting the inhibition zone with no brown circle and regrowth within the inhibition zone (type III). In the type II and III strains, Hcy disappeared, and other alkaloids were found in the inhibition zones in its place. Hcy feeding experiments using Penicillium purpurogenum (type II) and Cunninghamella elegans (type III) revealed that these fungi may convert Hcy to a new alkaloid compound.

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Section: Abbreviationmentioning

confidence: 97%

responses of fungi to tropane alkaloids produced by a medicinal plant Hyoscyamus muticus (Egyptian Henbane)

et al. 2009

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“…Data is reported for three replications. The calculation of percentage total alkaloid is given below (Nuhu and Ghani, 2002): …”

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confidence: 99%

Supercritical CO₂Extraction of Phytochemical Compounds from Mimosa pudica Linn

Rahmawati

Pang

et al. 2014

Chemical Engineering Communications

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The extraction of phytochemicals from Mimosa pudica Linn (MPL) using supercritical CO 2 has been studied and the results are presented in this paper. The significant variables affecting this extraction were investigated by DOE analysis. The effect of temperature and pressure on phytochemical yields was explored by measuring total phenolic compound (TPC), total flavonoid content (TFC), and total alkaloid compound (TAC).The maximum yield of TPC, TFC, and TAC extracted from MPL were 74.83 mg GAE/gram dry MPL, 30.93 mg QE/gram dry MPL and 14.23 mg HE/gram dry MPL, respectively. The work of Chrastil was used to correlate the experimental data. It was found that temperature and pressure greatly affected the yield of phytochemicals, whereas the effect of extraction time on the extraction yield diminished after 2h. Qualitative analysis of the phytochemicals extracted from MPL was performed by High Performance Liquid Chromatography (HPLC).The SC-CO 2 extraction was more selective than soxhlet extraction based on the HPLC spectra.

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“…An alkaloid known as scopolamine, a major compound isolated from D. metel, has been documented for curing various diseases including bronchitis and asthma (Dabur et al, 2004). Other tropane alkaloids isolated from D. metel are used as antispasmodic, mydriatic, and sedative agents (Nuhu, 2002). It is also an important source of withanolides, which is used to cure pain and has hallucinogenic potency (Abubakar et al, 2009;Yang et al, 2014;Arjun et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel’s Trumpet) Fruits

Rauf

Bawazeer

2020

Front. Pharmacol.

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Datura metel Linn is used traditionally for the treatment of various diseases including relaxation of smooth muscles, relief of fever, as well as gastrointestinal disorder. This study deals with the bio-guided isolation of an active, amyrin-type triterpenoid, namely 3-oxo-6b-hydroxy-b-amyrin (daturaolone; 1), from the chloroform fraction of Datura metel L. (Angel's trumpet) fruits and its gastrointestinal motility, antipyretic, and muscle relaxation effects in animal models. The chemical structure of daturaolone (1) was elucidated by NMR spectroscopy and crystallography techniques. The chloroform fraction and daturaolone (1) were assessed for the GIT motility test. Data exhibited in charcoal meal GI transit test show that chloroform fraction and daturaolone (1) significantly reduce GIT motility and increased intestinal transit time, comparable to the standard (atropine), a muscarinic receptor blocking agent. Muscle relaxant potency of the extract and daturaolone (1) was assessed in various animal paradigms. In the inclined plane screening test, it produced a significant (P < 0.05) muscle relaxation potential in a dose-dependent manner after 30, 60, and 90 min. Likewise, the muscle relaxation potential of the extract and daturaolone (1) was strongly complemented by the chimney and traction test, representing a dominant effect after 60 min of sample administration. The chloroform fraction showed good antipyretic activity, and while daturaolone (1) exhibited significant activity at a higher dose, the maximum effect (84.64%) was at 20 mg/kg i.p. In acute toxicity screening test, the chloroform extract (100, 250, 500, and 1,000 mg/kg) and daturaolone (1) (5, 10, 20, and 50 mg/kg) were found safe. In conclusion, the chloroform extract and daturaolone (1) exhibited strong gastrointestinal motility, muscle relaxation, and antipyretic activity in different animal models and intestinally, was found safe at higher tested doses.

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Alkaloid Content of the Leaves of Three Nbigerian Datura Species

Cited by 12 publications

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responses of fungi to tropane alkaloids produced by a medicinal plant Hyoscyamus muticus (Egyptian Henbane)

responses of fungi to tropane alkaloids produced by a medicinal plant Hyoscyamus muticus (Egyptian Henbane)

Supercritical CO₂Extraction of Phytochemical Compounds from Mimosa pudica Linn

Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel’s Trumpet) Fruits

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Alkaloid Content of the Leaves of Three Nbigerian Datura Species

Cited by 12 publications

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responses of fungi to tropane alkaloids produced by a medicinal plant Hyoscyamus muticus (Egyptian Henbane)

responses of fungi to tropane alkaloids produced by a medicinal plant Hyoscyamus muticus (Egyptian Henbane)

Supercritical CO2Extraction of Phytochemical Compounds from Mimosa pudica Linn

Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel’s Trumpet) Fruits

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Supercritical CO₂Extraction of Phytochemical Compounds from Mimosa pudica Linn