Alkaloid Composition of Chelidonium majus L. Studied by Different Chromatographic Techniques

Sárközi, Ágnes; Janicsák, Gábor; Kursinszki, L.; Kéry, Ágnes

doi:10.1365/s10337-006-0728-7

Cited by 59 publications

(41 citation statements)

References 18 publications

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“…Specifically, alterations involve disturbed DNA/RNA and related enzymes, as well as alterations to the cytoskeleton, ribosomal protein biosynthesis, and membrane permeability (Wink, 1998;Wink, 2008;Rosenkranz and Wink, 2008). The alkaloid berberine is present in C. majus extracts and Berberis extracts (Sárközi et al, 2006a;Zuo et al, 2011). Berberine inhibits esterases, DNA and RNA polymerases, cellular respiration, and acts in DNA intercalation (Aniszewski, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The C. majus extract contains a large number of alkaloids and polyphenols, and is therefore, known for its antimicrobial activity (Meng et al, 2009;Nawrot et al, 2007;Zuo et al, 2011). The main alkaloids identified in C. majus extracts are chelidonine, chelerythrine, sanguinarine, coptisine, and berberine (Sárközi et al, 2006a;Zuo et al, 2011). Formaldehyde formation due to demethylation is responsible for the antimicrobial activity of these alkaloids (Sárközi et al, 2006b).…”

Section: Measurement Of Induced Chlorophyll Fluorescence Parametersmentioning

confidence: 99%

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Chemical Composition of Celandine (Chelidonium majus L.) Extract and its Effects on Botrytis tulipae (Lib.) Lind Fungus and the Tulip

Pârvu

Vlase

Fodorpataki

et al. 2013

Not Bot Hort Agrobot Cluj

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In this study, the content of chelidonine and berberine alkaloids, and sterols and phenols in the Chelidonium majus plant extract were analyzed. Subsequently, the effects of the extract on the germination and growth of Botrytis tulipae fungus on nutritive medium were compared to the effects of fluconazole. The plant extract was used at the minimum inhibitory concentration on B. tulipae developed in tulip leaves and the in vivo effects were investigated. The influence of different concentrations of C. majus extract on the physiological processes of the tulip (gas exchange parameters, photosynthetic light use efficiency, and induced chlorophyll fluorescence) were also tested to assess the applicability of the extract for the protection of ornamental plants against fungal infection. Our results demonstrated that 2% celandine extract does not significantly change the gas exchange parameters (transpiration rate, carbon dioxide uptake, and stomatal conductivity) of leaves exposed for 2 h, and does not interfere with the photochemical processes in the leaves. However, in higher concentrations, it increases the transpiration rate and net carbon dioxide influx. At concentrations of 15% and 20%, the extract lowers the potential quantum yield efficiency of photosystem II and the vitality index of the photosynthetic apparatus. Therefore we recommend the use of lower concentrations (≤6%) of celandine extract for the biological protection of tulips against gray mold.

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Section: Discussionmentioning

confidence: 99%

Section: Measurement Of Induced Chlorophyll Fluorescence Parametersmentioning

confidence: 99%

Chemical Composition of Celandine (Chelidonium majus L.) Extract and its Effects on Botrytis tulipae (Lib.) Lind Fungus and the Tulip

Pârvu

Vlase

Fodorpataki

et al. 2013

Not Bot Hort Agrobot Cluj

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“…Detailed research on celandine composition showed that its anti-proliferative effect was due to the major extractable alkaloids: chelidonine, chelerythrine, sanguinarine, berberine and coptisine [4]. Despite their structural similarity, these compounds affect the living cells through different mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Amitozyn Impairs Chromosome Segregation and Induces Apoptosis via Mitotic Checkpoint Activation

et al. 2013

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Amitozyn (Am) is a semi-synthetic drug produced by the alkylation of major celandine (Chelidonium majus L.) alkaloids with the organophosphorous compound N,N’N’-triethylenethiophosphoramide (ThioTEPA). We show here that the treatment of living cells with Am reversibly perturbs the microtubule cytoskeleton, provoking a dose-dependent cell arrest in the M phase. Am changed the dynamics of tubulin polymerization in vitro, promoted the appearance of aberrant mitotic phenotypes in HeLa cells and induced apoptosis by the activation of caspase-9, caspase-3 and PARP, without inducing DNA breaks. Am treatment of HeLa cells induced changes in the phosphorylation of the growth suppressor pRb that coincided with maximum mitotic index. The dose-dependent and reversible anti-proliferative effect of Am was observed in several transformed cell lines. Importantly, the drug was also efficient against multidrug-resistant, paclitaxel-resistant or p53-deficient cells. Our results thus open the way to further pre-clinical evaluation of Am.

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“…These 2 alkaloids exhibit multiple biological and pharmaceutical effects, such as antiinflammatory [22], antitumor [23], and antimicrobial activity [24]. High-performance liquid chromatography (HPLC) methods [25][26][27] have previously been used to separate CHE and SAN, but HPLC often need time-consuming sample preparation steps, large solvent consumption and long analysis time. As an improvement, an ultra-performance liquid chromatography (UPLC) was developed [28], which showed some advantages such as reduced run time, increased peak capacities and less solvent consumption, but the technique still requires tedious sample preparation (reflux extraction followed by solid-phase extraction) prior to UPLC analysis.…”

Section: Introductionmentioning

confidence: 99%

Microchip electrophoretic separation and fluorescence detection of chelerythrine and sanguinarine in medicinal plants

Sun

Zeng

et al. 2015

Talanta

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Alkaloid Composition of Chelidonium majus L. Studied by Different Chromatographic Techniques

Cited by 59 publications

References 18 publications

Chemical Composition of Celandine (<i>Chelidonium majus</i> L.) Extract and its Effects on <i>Botrytis tulipae</i> (Lib.) Lind Fungus and the Tulip

Chemical Composition of Celandine (<i>Chelidonium majus</i> L.) Extract and its Effects on <i>Botrytis tulipae</i> (Lib.) Lind Fungus and the Tulip

Amitozyn Impairs Chromosome Segregation and Induces Apoptosis via Mitotic Checkpoint Activation

Microchip electrophoretic separation and fluorescence detection of chelerythrine and sanguinarine in medicinal plants

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