Alkaloid chemistry

Profile and Content of Residual Alkaloids in Ten Ecotypes of Lupinus mutabilis Sweet after Aqueous Debittering Process

“…Although 13-hydroxylupanine, 17-oxosparteine and 11, 12-dehydrosparteine have been described in L. mutabilis [16,17], they were not identified in the ecotypes investigated in our research. Some of the alkaloids detected are common in other species too, e.g., angustifoline, lupanine and sparteine in L. albus seeds, sparteine in L. luteus, lupanine in L. hispanicus, and angustifoline in L. angustifolius [23][24][25][26][27]. It is worth noting that alkaloids such as α-piridone, cytisine, and anagyrine, which are highly poisonous for invertebrates and common in wild species [23], were not found in the samples of L. mutabilis.…”

Antileishmanial activity of synthetic analogs of the naturally occurring quinolone alkaloid N-methyl-8-methoxyflindersin

“…Our results showed that synthetic compounds 2 and 8 show antileishmanial activity against both parasitic stages (promastigotes and amastigotes), and compound 2 induces oxidative burst in hMDMs, with a significant bearing on improving treatment for and curing CL. The search strategy for compounds showing antiparasitic activity and structural similarity identified two synthetic compounds with similar activity as that shown by a naturally occurring metabolite (used as a base compound), differing with regard to oxygen and nitrogen substitutes or free radicals in their structure [12,13]. This suggests that an in silico strategy could help find new alternatives to overcome the limitations in developing new medicines from natural molecules and facilitate the continuation of drug development in preclinical or clinical studies.…”

“…Using natural molecules and their synthetic derivatives is the main strategy followed in the search for new therapeutic options [7]. Of these, quinoline alkaloids, which are secondary metabolites found mainly in plants from the Rutaceae family, are biosynthesized from anthranilic acid and comprise carboxyl groups of anthranilic acid with an acetate group (malonate) and their subsequent cyclization of the quinolinic ring [12,13]. Quinoline alkaloids are effective against CL caused by L. amazonensis and L. venezuelensis in BALB/c mice [14].…”

“…Compound 1 has a direct effect on L. (V.) panamensis promastigotes and reduces the number of parasites internalized in dendritic cells [18]. However, it cannot be synthesized because of its relatively low amount extracted from its natural source [19] and its complex structure [12,13], making it difficult to obtain sufficient amount of material for preclinical studies to validate its therapeutic potential.…”

Design, Synthesis and Evaluation of New Marine Alkaloid-Derived Pentacyclic Structures with Anti-Tumoral Potency

“…Indeed, the unique molecular architecture of these natural substances may serve as primary stimulus for innovation and creativity to provide precisely engineered chemical solutions for complex biological phenomena. Among secondary metabolites is found a class of compounds called alkaloids [ 3 , 4 , 5 ]. This concept, introduced by Meissner [ 6 ] from the latin alkali (basic) regroups many chemical structures that are important sources of bioactive compounds, such as ellipticine [ 7 ], neoamphimedine, isolated from xestospongia sponge [ 8 ] or makaluvamine A [ 9 ] ( Figure 1 ), extracted from another marine sponge.…”