Alkaloid Based Chemical Constituents of Ocimum santum & Cinchona Bark : A Meta Analysis

Abstract

This article provides a concise summary of the recent developments that have been achieved in our comprehension of the asymmetric addition processes that are catalysed by native Cinchona alkaloids and their derivatives. This class of reactions includes cycloadditions, 1,4-adds, direct nucleophilic additions across carbon–oxygen or carbon–nitrogen double bonds, and direct nucleophilic additions across carbon–oxygen double bonds. Because of their capacity to catalyse the addition of a wide variety of functional groups to C9, many Cinchona alkaloids have been utilised in these processes as catalysts. These functional groups include amino, alkoxy, hydroxyl, amido, urea, and thiourea, among others. The importance of mechanical variables is emphasised in many different contexts. Additionally, the utilisation of adducts in future synthesis is sometimes broken down into its component steps. Ocimum basilicum was discovered to be mostly consisted of estragol (> 35.71 percent), (E)-ocimene (> 1.47 percent), trans-bergamotene (> 0.83 percent), a-cadinol (> 0.41 percent), eucalyptol (> 0.25 percent), and -caryophyllene (> 0.07 percent), whereas Ocimum sanctum is primarily composed of eucaly There is a greater concentration of chemical components in the leaves of Ocimum basilicum and Ocimum sanctum than there is in the actual inflorescence or flowers of the plant. The genetic distance between the two species was analysed in order to better understand the interspecies relationship, and the results showed that it was 2.86. The small difference in genetic makeup that exists between Ocimum basilicum and Ocimum sanctum is evidence that these two species are related to one another and share similar traits.

Plants Alkaloids Based Compound as Therapeutic Potential for Neurodegenerative

“…Hawthorn pulp and seed extracts demonstrated analgesic efficacy in rats and inhibited exploratory behaviors in hole-board trials and spontaneous locomotion in activity cage tests [80,81], suggesting that this plant may be effective for treating stress, anxiety, sleep difficulties, and pain control. In a more recent study [82], hawthorn and chlordiazepoxide equally reduced the anxiety of sixty female laboratory mice. The experimental groups included control (no anxiety and no injection; n = 10), anxiety (no injection; n = 10), chlordiazepoxide (1.2 mg/kg intraperitoneal dose; n = 10), and treatment (50, 100, and 200 mg/kg intraperitoneal dose; n = 30).…”

“…Hops include compounds from five different groups of flavonoids and derivatives, the majority of which are concentrated in the seeds and bracts of female inflorescences: chalcones, flavanones, flavonols, flavan-3-ols, and kaempferol. The bulk of the hydroxycinnamic acids in hops are composed of caffeine, ferulic acid, and sinapic acid, while the majority of the hydroxybenzoic acids are composed of gallic acid, syringic acid, and vanillic acid [94,95]. The bitter acid equivalents humulone and lupulone are the most prevalent phloroglucinol derivatives found in hops [96,97].…”

Herbal used as Epigenetic for Cancer Treatment

“…Because of the potential for DNA-damaging therapies and epigenetic agents to have a synergistic effect, trial designs that include stratification biomarker screening will need to be carefully considered. Demethylation of genes such as MGMT and BRCA1 can result in resistance to cytotoxics and treatment failure; however, demethylation of MMR genes and other proapoptotic genes can increase efficacy in response to cytotoxics that induce DNA damage [65]. DNAdemethylating agents are a clear illustration of this phenomenon.…”

Recent Approaches of Ocular Disease and Its Herbal Product Treatment: An Updates

“…Results showed a significant reduction in hyperglycemia, the diameter of the retinal vessels, and vascular basement membrane thickness. [109] Improvement in the structural changes of the retinal vasculature was associated with significantly reduced expression of nuclear factor-κB (NF-κB) and reduced activity of tumour necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) in the retinal tissue. In another study, the anti-glaucoma activity of aqueous methanolic extract of ginger against carbomer-induced experimental glaucoma in rabbits have been evaluated.…”