Alkalization of wall paint prevents airborne contact dermatitis in patients with sensitization to isothiazolinones*

Braun‐Falco, Markus; Knott, E. Marty; Huss‐Marp, Johannes; Ring, J; Hofmann, Heidelore

doi:10.1111/j.1600-0536.2008.01356.x

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…Chemical deactivation procedures have also been reported, such as paint alkalinization, to obtain a pH of around 10–11. This still prevents microbial contamination and may guarantee stability for 2 years . Another alternative is glutathione, a tripeptide antioxidant, which need to be prepared in a cream at 2.0%, could enable workers sensitized to MCI or MI to continue working with these derivatives .…”

Section: Preventionmentioning

confidence: 99%

“…This still prevents microbial contamination and may guarantee stability for 2 years. 123 Another alternative is glutathione, a tripeptide antioxidant, which need to be prepared in a cream at 2.0%, could enable workers sensitized to MCI or MI to continue working with these derivatives. 124 As glutathione breaks the chemical ring structure of MCI and MI, it was reported to deactivate MCI/MI up to a concentration of 2400 ppm (0.24%).…”

Section: Labellingmentioning

confidence: 99%

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Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Herman

Aerts

Montjoye

et al. 2019

Acad Dermatol Venereol

111

115

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Allergic contact dermatitis (ACD) from isothiazolinones has frequently been described in the literature. Following an epidemic of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in the 1980s, and more recently to MI, the Scientific Committee on Consumer Safety of the European Commission banned their use in leave‐on products, while restricting that in rinse‐off cosmetics. Despite a decreasing prevalence of ACD from MCI/MI and MI, cases caused by occupational exposure and non‐cosmetic isothiazolinone sources are on the rise. Moreover, sensitization to newer and lesser known isothiazolinones has been reported. This paper reviews the epidemiology of contact allergy to different isothiazolinones, clinical presentation of isothiazolinone‐induced ACD, most relevant sensitization sources and potential cross‐reactions between isothiazolinone derivatives. It also provides an update on recent legislative measures.

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Section: Preventionmentioning

confidence: 99%

Section: Labellingmentioning

confidence: 99%

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Herman

Aerts

Montjoye

et al. 2019

Acad Dermatol Venereol

111

115

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…MCI and MI are considered high potent contact allergens and are one of the most common causes of contact allergy and dermatitis induced by preservatives (Braun-Falco et al 2008; Castanedo-Tardana and Zug 2013). Several studies have reported airborne contact dermatitis after recent exposure to water-based paint containing MCI and MI (e.g., Bohn et al (2000); Braun-Falco et al (2008); Breuer et al (2015); Lundov et al (2014); Reinhard et al (2001); Wright and Cahill (2015)). Furthermore, various studies and case reports have described allergic contact dermatitis (ACD) following skin exposure (e.g., Ackermann et al (2011);Carlsen et al (2008); Cleenewerck (2008); Lundov et al (2011); Mendonca et al (2014); Puangpet et al…”

Section: Introductionmentioning

confidence: 99%

Ex vivo human skin permeation of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI)

et al. 2017

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Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are biocides used in many types of products such as cosmetics, paints, and cleaning agents. Skin contact is often encountered when using these products. Although MCI and MI are strong allergens and cause skin irritation, no scientific skin permeation study has been reported except for some unpublished data. Therefore, this study assessed the permeation of MCI and MI both separately and as a mixture through freshly dermatomed human skin (800 µm) in a flow-through diffusion cell system. Different concentrations of aqueous standards (1.5/1, 70/50, 150/35, and 750/175 µg/mL of MCI/MI) and various commercial products were assessed after 15 to 20 hours of exposure. In parallel, the dose dependent irritant effects of MCI/MI and MI were estimated by histology following 6-h or 24-h exposure. Overall results show that MI in formulations or in aqueous standard solutions quickly permeated the skin with time lags less than 15 minutes while MCI was much slower (>3.5 h). MCI in formulations had permeation rates up to five times greater than for MI in the same product, and in two tested creams were not found to permeate skin. Some signs of irritation were observed by histology; especially at the highest MCI/MI concentrations (750/205 µg/mL) in aqueous solutions. This confirms that MCI reacts readily with skin and may induce local irritation. The MCI and MI permeations are also greatly influenced by the topical vehicle. It is therefore more relevant to test exposures to formulations than aqueous standard solutions.

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“…Braun-Falco M. 30 (2008) realiza un estudio en 4 trabajadores (3 varones y 1 mujer) que habían desarrollado DCAT secundaria a Kathon CG (metilisotiazolina (MI) y metilcloroisotiazolina (MCI)), conservante antibacteriano y antifúngico utilizado en cosméticos, productos industriales y productos domésticos. No existe ni aleatorización ni grupo control.…”

unclassified

Dermatitis aerotrasportada de origen laboral en la industria química, farmacéutica y sector sanitario

Cervera

Perdomo

Barbero³

2014

Med. segur. trab.

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MEDICINA y SEGURIDAD del trabajo Octubre -diciembre 2014 Med Segur Trab (Internet) 2014 60 (237) 742-755 Dermatitis aerotransportada de origen laboral en la industria química, farmacéutica y sector sanitario Jaureguizar Cervera E., Pérez Perdomo M., Reinoso Barbero, L. 742 RevisionesDermatitis aerotrasportada de origen laboral en la industria química, farmacéutica y sector sanitarioAirborne contact dermatitis in chemical and pharmaceutical industry and healthcare sectorsJaureguizar Cervera E. ResumenIntroducción: La dermatitis de contacto aerotransportada (DCAT), es una forma de dermatitis profesional que por su manifestación clínica, localización y forma de contacto presentan característica propias, este hecho junto con la relevancia de la dermatosis dentro de la morbilidad profesional justifica la necesidad de sintetizar la evidencia científica existente mediante una revisión sistemática.Objetivos: Identificar la evidencia científica sobre la DCAT, la existencia de un consenso sobre criterios diagnósticos, las medidas de prevención y la identificación de población especialmente sensible. Material y métodos:Revisión sistemática de la producción científica publicada entre 2006 y 20014 sobre DCAT, se realizó una búsqueda sistemática mediante términos DeCS, MeSH, en diversas bases de datos y otros recursos informáticos (MEDLINE, COCHRANE, SCOPUS, SCIELO, OVID, BNCS, OSH, UPDATE). La evidencia se evaluó con los criterios SIGN.Resultados: Tras el proceso de selección el resultado final fue de 15 artículos a analizar del total recuperado de 504. Los tipos de diseño: 1 Ensayo Clínico no aleatorizado sin grupo control y 14 Series de Casos, de los cuales 7 usaron grupo control. Las sustancias químicas que produjeron DCAT no publicadas previamente fueron: TFA, fibras PP y PE, Dihidrocloruro 2 2'-azobis (2-metilpropanamida) y HBTU 743MEDICINA y SEGURIDAD del trabajoNo se puede demostrar ninguna población especialmente sensible, se puede concluir que la DCAT está cobrando importancia, y que se debe mejorar la producción científica con diseños que generen un mayor nivel de evidencia que permitan tomar las medidas preventivas adecuadas. (Internet) 2014; 60 (237) Med Segur Trab AbstractIntroduction: Due to its location, clinical signs and form of contact, the airborne contact dermatitis (ABCD) is a unique type of occupational dermatitis. It results unquestionable the need of synthetising the scientific evidence through a systematic review taking into account the dermathoses relevance in the occupational morbidity.Objectives: To identify the scientific evidence for ABCD, the existence of a consensus on diagnostic criteria, on preventive measures and on the identification of especially sensitive population. Material and methods:A systematic review of the scientific literature published between 2006 and 2014 about ABCD. A systematic search was performed using DeCS, MeSH, in various databases and other computer resources (MEDLINE, COCHRANE, SCOPUS, SCIELO, OVID, BNCS, OSH, UPDATE). The evidence was evaluated following a ...

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Alkalization of wall paint prevents airborne contact dermatitis in patients with sensitization to isothiazolinones*

Cited by 9 publications

References 7 publications

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Ex vivo human skin permeation of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI)

Dermatitis aerotrasportada de origen laboral en la industria química, farmacéutica y sector sanitario

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