Alkalization of blood pH is responsible for survival of cancer patients by mild hyperthermia

Abstract

The effect of mild hyperthermia on venous blood pH was examined in 6 cancer patients. Mild hyperthermia was induced by continuation of a rectal temperature of 39.5°C for 30 min. All 6 patients were diagnosed as suffering from advanced cancer with or without surgery and chemotherapy pretreatments. In Cases 1 to 5, but not Case 6, venous blood pH was alkalized up to pH 7.7 by this mild hyperthermia and the effect was reproduced depending on the application of hyperthermia. At this time, alkalized pH was accompanied by increased PO 2 and decreased PCO 2 in the blood. These patients showed good physical conditions and improved clinical data. On the other hand, hyperthermia could not be continued in Case 6 due to his worsened physical condition. The present data suggest that mild hyperthermia is a useful method to improve circulation failure, physical condition and clinical data.Many cancer patients are suffering from hypothermia and circulation failure (8,11,12,18) due to vessel constriction induced by sympathetic nerve activation (1, 19). As a result, immunosuppression is often accompanied with these patients, showing lymphocytopenia. Restoration from this circulation failure seems to be important for the treatment of cancer. In this regard, there have been many trials of hyperthermia for the treatment of malignancy (6,9,17,20). Hyperthermia indeed ameliorates not only immune functions but also other physical conditions. In the course of these studies, we have noticed that hyperthermia (i.e., > 40°C) sometimes induced rather immunosuppression as a thermal stress (14). At this time, persons who experienced with hyperthermia showed granulocytosis and lymphocytopenia after the treatment. This might be due to the fact that overexposure of hyperthermia induced stressassociated sympathetic nerve activation and that granulocytes bear surface adrenergic receptors but lymphocytes bear surface cholinergic receptors (13,15). A similar response was also reported in animal studies (16). Dogs and cats which experienced with severe hyperthermia showed immunosuppression, showing granulocytosis and lymphocytopenia.In an earlier study, we showed that hyperthermia at the level up to 39.5°C (rectal temperature) for 30 min did not induce granulocytosis but rather induced immunopotentiation (14). In the present study, we applied this condition of hyperthermia for 6 cancer patients. As shown previously and in this study, an appropriate condition of hyperthermia is well correlated with the alkalization of blood pH with increased PO 2 and decreased PCO 2 after the application of hyperthermia. MATERIAL AND METHODS Subjects. Diagnosis of all cancer patients, including

Skin rubdown with a dry towel, ^|^lsquo;kanpu-masatsu' is an aerobic exercise affecting body temperature, energy production, and the immune and autonomic nervous systems

“…4). served, due to the increase of PO 2 and sO 2 as seen in our previous studies (10,18,23). Of interest was the change in RBC conformation (Fig.…”

Internal environment in cancer patients and proposal that carcinogenesis is adaptive response of glycolysis to overcome adverse internal conditions

“…In some cases, tumor regression resulted from mild hyperthermia [45]. At this time, the values of pH, PO 2 , PCO 2 and other factors improved.…”

“…In our recent study using hyperthermia equipment [44,45], many cancer patients could live in good conditions without further tumor enlargement when they exposed to mild hyperthermia (i.e., the maximum rectum temperature is 38.0ºC for 15-30 min). In some cases, tumor regression resulted from mild hyperthermia [45].…”

The effects of application of an ancient type of acupuncture needle on body temperature, immune function and the autonomic nerve system

“…Fresh venous blood was obtained before and after the DZ application for the measurement of PO 2 , SO 2 , PCO 2 and hemoglobin, using i-STAT 300 F (i-STAT Corporation, East Windsor, NJ, USA) as previously described [4][5][6][7]. WBCs were measured using a hemocytometer and the May-Grünwald Giemsa stain method.…”