Alkalinization of Lidocaine Does not Hasten the Onset of Axillary Brachial Plexus Block

Chow, Mark Y. H.; Sia, Alex; Koay, C. K.; Chan, YM

doi:10.1213/00000539-199803000-00024

Cited by 32 publications

(11 citation statements)

References 6 publications

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“…There are reports of no improvement with alkalinisation also. 21,22 Further studies comparing the effects of addition of fentanyl to local anaesthetic using different pH solution are required to confirm this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study Between Bupivacaine Alone and Bupivacaine With Fentanyl in Axillary Plexus Block for Upper Limb Surgeries

P.V¹,

T²

2018

jebmh

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BACKGROUNDThe addition of adjuncts like Neostigmine, opioids, midazolam, dexmedetomidine, hyaluronidase, clonidine etc., to local anaesthetics for brachial plexus block may enhance the quality and duration of analgesia. Fentanyl, a phenylpiperidine derivative, is known to produce antinociception and enhance the effect of local anaesthetics when given epidurally or intrathecally. The purpose of the present study is to assess the effect of fentanyl added to brachial plexus block by axillary approach.

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Section: Discussionmentioning

confidence: 99%

Comparative Study Between Bupivacaine Alone and Bupivacaine With Fentanyl in Axillary Plexus Block for Upper Limb Surgeries

P.V¹,

T²

2018

jebmh

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“…There are reports of no improvement with alkalinisation also. 26,27 Further studies comparing the effects of addition Minutes of fentanyl to local anaesthetic using different pH solution are required to confirm this hypothesis. One of the limitations of our study is low sample size.…”

Section: Discussionmentioning

confidence: 99%

Does fentanyl prolong the analgesia of local anaesthetics in brachial plexus block? A randomized controlled study

Kaniyil

Radhakrishnan

2017

Int J Res Med Sci

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Background: Several adjuvants have been added to enhance the effects of local anaesthetic agents in peripheral nerve blocks. In this randomized controlled study we aimed to assess the effects of addition of fentanyl to local anaesthetics in brachial plexus block with respect to onset time and total duration of analgesia.Methods: In this prospective randomized double- blind study, 40 adult patients of 18-65 years age group were randomly divided into two groups of 20 each. In group L supracavicular brachial plexus block was performed with 30 ml of local anaesthetic solution (10 ml 1.5% lignocaine with adrenaline +20 ml 0.25% bupivacaine) +1ml saline whereas in group LF received the same 30 ml local anaesthetics with 50µg fentanyl in 1ml added to it. The characteristics of block with respect to onset time of sensory and motor blockade, total duration of analgesia and any side effects were evaluated.Results: Both groups were comparable with respect to demographic parameters and duration of surgery. The onset time of complete sensory and motor block was significantly prolonged in group LF (17.2±2.5min and 20.3±2.9min) compared to group L (13.7±3.6min and 17.45±3.7min). The total duration of analgesia was also significantly prolonged (P <0.001) in group LF (374.5±51min) compared to group L (239.25±40.27min). There were no significant side effects noted in any patients in both groups.Conclusions: Addition of fentanyl to local anesthetics in brachial plexus block significantly prolonged the duration of analgesia without any significant side effects though it had delayed the onset of block.

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“…З іншими місцевими анестетиками, такими як лідокаїн, наявність або відсутність адреналіну може змінити дію натрію гідрокарбонату в розчині, викликаючи можливе скорочення часу настання, але також може зменшувати ступінь і тривалість знеболення, за даними Sinnott et al [102,103]. Крім того, натрій бікарбонат не був дозволений для клінічного застосування як лужна речовина для місцевих анестетиків; таким чином, його використання слід здійснювати обережно [49].…”

Section: оглядunclassified

Adjuvants in pain medicine. Selection of the drug depending on the desired effect – so which drug to choose?

Dmytrіiev

Lisak

Zaletska

2020

PMJUA

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To date, much research has focused on finding the ideal adjuvant for local anesthetics. Each of them can have different effects. In anesthesiology and pain medicine, depending on the purpose, one or another effect may be desirable. For example, in some situations it is desirable to accelerate the onset of action or prolong the duration of the block, in others the desired effect may be a “response to intravascular administration”, it should also be borne in mind that not all adjuvants are allowed for intrathecal administration.

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Alkalinization of Lidocaine Does not Hasten the Onset of Axillary Brachial Plexus Block

Cited by 32 publications

References 6 publications

Comparative Study Between Bupivacaine Alone and Bupivacaine With Fentanyl in Axillary Plexus Block for Upper Limb Surgeries

Comparative Study Between Bupivacaine Alone and Bupivacaine With Fentanyl in Axillary Plexus Block for Upper Limb Surgeries

Does fentanyl prolong the analgesia of local anaesthetics in brachial plexus block? A randomized controlled study

Adjuvants in pain medicine. Selection of the drug depending on the desired effect – so which drug to choose?

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