Alkaline phosphatase: the isoenzyme pattern in the elderly and changes in total serum levels with age

Sharland, D. E.

doi:10.1016/0009-8981(74)90227-7

Cited by 12 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…109 (22-527)*** y-GT (U/I)t 14 (2-252) 10 (2-335)*** Total calcium (mmol/l) 2-37 (0-10) 2-36 (0-11) Magnesium (mmol/l) 1-01 (0 07) 1-00 (0-08) Urinary measurements:…”

Section: Serum Total Calcium Concentrationmentioning

confidence: 99%

Effects of exposure to cadmium on calcium metabolism: a population study.

Staessen

Améry

Bernard

et al. 1991

Occupational and Environmental Medicine

View full text Add to dashboard Cite

The objective was to investigate the hypothesis that environmental exposure to cadmium may affect calcium metabolism in the population at large. The 1987 participants (965 men and 1022 women), from 20 to 80 years old, constituted a random sample of the population of four Belgian districts. The urinary excretion of cadmium, a measure of lifetime exposure, averaged 9-3 nmol/24 h in men (range 0 4-324 nmol/24 h) and 7-1 nmol/24 h (range 0-1-71 nmol/24 h) in women. Serum alkaline phosphatase activity and the urinary excretion of calcium correlated significantly and positively with urinary cadmium excretion in both men and women, and serum total calcium concentration negatively with urinary cadmium excretion in men only. The regression coefficients obtained after adjustment for significant covariates indicated that when urinary cadmium excretion increased twofold, serum alkaline phosphatase activity and urinary calcium excretion rose by 3-4% and 0 25 mmoll24 h respectively, whereas in men serum total calcium concentration fell by 6 umolIl.After adjustment for significant covariates the relation between serum total calcium concentration and urinary cadmium excretion was Cadmium interferes with the metabolism of vitamin D, calcium, and collagen, and its accumulation may lead to osteomalacia and osteoporosis.'2 These effects are usually considered to be late manifestations of severe cadmium poisoning, and have been seen in exposed workers and in malnourished subjects.'" The quantitative dose-response relation for the effects of cadmium on calcium and bone metabolism, however, remains presently unknown. The present report, part of a cross sectional study on the effects of cadmium on public health,"7 investigated whether environmental exposure to cadmium influences calcium metabolism in the population at large. Methods SUBJECTSAs described elsewhere,"7 the 2327 subjects (age range from 20 to 79) constituted a random sample of the population of four Belgian districts selected to provide a wide range of environmental exposure to cadmium. Subjects were excluded from the present analysis when not all relevant measurements were available (n = 248), when 24 hour urine samples were judged under or over collected by previously published criteria (n = 44),8 or when either occupational exposure to heavy metals (n = 41) or smoking habits (n = 7) could not be ascertained from a self administered questionnaire.

show abstract

“…109 (22-527)*** y-GT (U/I)t 14 (2-252) 10 (2-335)*** Total calcium (mmol/l) 2-37 (0-10) 2-36 (0-11) Magnesium (mmol/l) 1-01 (0 07) 1-00 (0-08) Urinary measurements:…”

Section: Serum Total Calcium Concentrationmentioning

confidence: 99%

Effects of exposure to cadmium on calcium metabolism: a population study.

Staessen

Améry

Bernard

et al. 1991

Occupational and Environmental Medicine

View full text Add to dashboard Cite

show abstract

“…While we did see an increase in ALP of 25% above the reference range for six dogs, as well as four dogs that were below the reference range at one or more time point, these observations were independent of treatment oil and all dogs remained clinically healthy with no other abnormalities reported by owners. Increases in ALP are non-specific and ALP concentrations may be influenced by a variety of factors, including sex, age, and breed [29,[32][33][34][35], as such, the large variability both in the current data, as well as in the literature, suggests the variability in ALP results are due to normal biological variation or other non-treatment related factors. While significant differences were seen among treatments for both GGT and ALT, all values remained within reference range (Animal Health Laboratory, Guelph, Canada).…”

Section: Hematology and Biochemistrymentioning

confidence: 83%

Safety of Dietary Camelina Oil Supplementation in Healthy, Adult Dogs

Burron

Richards

Patterson

et al. 2021

Preprint

View full text Add to dashboard Cite

This study aimed to determine whether camelina oil is safe for use in canine diets, using canola oil and flax oil as controls as they are similar and generally regarded as safe (GRAS) for canine diets. Thirty privately-owned adult dogs of various breeds (17 females; 13 males), with an average age of 7.2 ± 3.1 years (mean ± SD) and body weight (BW) of 27.4 ± 14.0 were used. After a 4-week wash-in period using sunflower oil and kibble, dogs were blocked by breed, age, and size, and randomly allocated to one of three treatment oils (camelina (CAM), flax (FLX), or canola (OLA)) at a level of 8.2 g oil/100g total dietary intake. Body condition score (BCS), BW, food intake (FI), and hematological and select biochemical parameters were measured at various timepoints over a 16-week feeding period. All data were analyzed with ANOVA using PROC GLIMMIX of SAS. No biologically significant differences were seen between treatment groups for BW, BCS, FI, hematological and biochemical results. Statistically significant differences noted among some serum biochemical results were considered small and due to normal biological variation. These results support a conclusion that camelina oil is safe for use in canine nutrition.

show abstract

“…While we did see an increase in the ALP of 25% above the reference range for six dogs and even though four dogs were below the reference range at one or more time point, these observations were independent of treatment oil, and all of the dogs remained clinically healthy with no other abnormalities reported by the owners. Increases in ALP are non-specific, and ALP concentrations may be influenced by a variety of factors, including sex, age, and breed [ 29 , 31 , 32 , 33 , 34 ]; as such, the large variability in both the current data as well as in the literature suggests that the variability in the ALP results are due to normal biological variation or other non-treatment related factors.…”

Section: Discussionmentioning

confidence: 99%

Safety of Dietary Camelina Oil Supplementation in Healthy, Adult Dogs

Burron

Richards

Patterson

et al. 2021

Animals

View full text Add to dashboard Cite

This study aimed to determine whether camelina oil is safe for use in canine diets, using canola oil and flax oil as controls, as they are similar and generally regarded as safe (GRAS) for canine diets. A total of thirty privately-owned adult dogs of various breeds (17 females; 13 males), with an average age of 7.2 ± 3.1 years (mean ± SD) and a body weight (BW) of 27.4 ± 14.0 kg were used. After a 4-week wash-in period using sunflower oil and kibble, the dogs were blocked by breed, age, and size and were randomly allocated to one of three treatment oils (camelina (CAM), flax (FLX), or canola (OLA)) at a level of 8.2 g oil/100 g total dietary intake. Body condition score (BCS), BW, food intake (FI), and hematological and select biochemical parameters were measured at various timepoints over a 16-week feeding period. All of the data were analyzed with ANOVA using the PROC GLIMMIX of SAS. No biologically significant differences were seen between the treatment groups in terms of BW, BCS, FI, and hematological and biochemical results. Statistically significant differences noted among some serum biochemical results were considered small and were due to normal biological variation. These results support the conclusion that camelina oil is safe for use in canine nutrition.

show abstract

Alkaline phosphatase: the isoenzyme pattern in the elderly and changes in total serum levels with age

Cited by 12 publications

References 12 publications

Effects of exposure to cadmium on calcium metabolism: a population study.

Effects of exposure to cadmium on calcium metabolism: a population study.

Safety of Dietary Camelina Oil Supplementation in Healthy, Adult Dogs

Safety of Dietary Camelina Oil Supplementation in Healthy, Adult Dogs

Contact Info

Product

Resources

About