Alkaline phosphatase activity and tetracycline incorporation during initial orthodontic tooth movement in rats

Lilja, Eva; Lindskog, Sven; Hammarström, Lars

doi:10.3109/00016358409041125

Cited by 24 publications

(17 citation statements)

References 22 publications

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“…In support of this finding, Lilja, Lindskog, and Hammarstrom (1984) have shown through histochemical techniques that ALP is present in the normal periodontal membrane in rats. [15] Lindhe (1996) showed that even in healthy gingiva, certain leukocytes (neutrophils) can be seen in the junctional epithelium. [16]…”

Section: Discussionmentioning

confidence: 99%

Gingival crevicular fluid alkaline phosphatase as a potential diagnostic marker of periodontal disease

Sanikop¹,

Patil²,

Agrawal³

2012

J Indian Soc Periodontol

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Background:Alkaline phosphatase (ALP) enzyme is involved in the destruction of the human periodontium. The present study was conducted to determine the presence and levels of ALP activity in gingival crevicular fluid (GCF) in periodontal health, gingivitis, and chronic periodontitis.Materials and Methods:GCF samples were collected from 45 sites which were divided into three equal groups of healthy samples and gingivitis and chronic periodontitis samples. Various clinical parameters were evaluated and the levels of ALP were estimated using a semi-autoanalyzer. Analysis of variance was employed to compare the ALP levels in different groups. Pearson's correlation coefficient was utilized to find the correlation between ALP levels and various clinical parameters.Results:Difference in the mean ALP levels between healthy and gingivitis groups was found to be nonsignificant (P>0.05) and that between the chronic periodontitis group and healthy as well as gingivitis groups was found to be highly significant (P<0.001). Significant correlations existed between ALP levels and gingival index, probing depths, as well as clinical attachment levels.Conclusion:The finding of the present study confirms the relationship between ALP level and periodontal disease, thus indicating that GCF ALP levels can be used as potential biochemical markers for the detection and progression of periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Gingival crevicular fluid alkaline phosphatase as a potential diagnostic marker of periodontal disease

Sanikop¹,

Patil²,

Agrawal³

2012

J Indian Soc Periodontol

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“…It has a marked activity of alkaline phosphatase similar to that of the periosteum. This activity extends above the alveolar crest to the gingivai margin (Lilja et al 1984).…”

Section: Teethmentioning

confidence: 97%

General morphological aspects of resorption of teeth and alveolar bone

1985

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Summary. This is a review of our present knowledge of the mechanisms involved in the resorption of teeth and alveolar bone. Special attention has been paid to the morphology and function of osteoclasts and osteocytes. The dental mineralized tissues do not normally undergo resorption and the mechanisms behind this resistance are discussed. Finally, an attempt has been made to distinguish those factors which regulate activity, of resorption from those which determine its location.

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“…The periodontal membrane can be regarded as a special adaptation of the periosteum (23). Enzyme histochemical studies give the impression that the periodontal membrane is a continuation of the periosteum (24). The healing of the periodontal tissues after replantation of an avulsed tooth may thus be compared with the callus formation after fracture of a bone.…”

Section: Discossionmentioning

confidence: 99%

Dynamics of dentoalveolar ankylosis and associated root resorption

Hammarström

Blomlöf

Lindskog

1989

Dental Traumatology

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165

138

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The present experimental studies in monkeys were undertaken to study the initiation and progression of dentoalveolar ankylosis of replanted teeth and associated root resorption. Maxillary and mandibular lateral incisors were extracted and replanted after an extraoral period of 15 min or 1 h. Teeth with an extraoral period of 1 h were endodontically treated. Half the number of monkeys were given antibiotics at the time of replantation. The observation periods varied from 2 days to 40 weeks. Irrespective of the length of the extraoral period, initial root resorption and minor areas of ankylosis were found 1 week after replantation. The initial ankylosis was not preceded by root resorption. In teeth replanted after an extraoral period of 15 min the ankylotic area did not increase with increasing time after replantation. Instead the periodontal membrane was re-established, separating the root surface from the alveolar bone. In teeth replanted after an extraoral period of 1 h, the initial ankylotic area increased with increasing time after replantation. Eight weeks and more after replantation, most of the periodontal membrane was replaced by bone covered by osteoblasts and occasional osteoblasts that were in continuity with the endosteal cells outlining the marrow spaces of the alveolar bone. The cementum and dentin were then gradually resorbed with increasing time after replantation. Antibiotics given at the time of replantation reduced the initial inflammation in the periodontal membrane and the inflammatory root resorption after all observation periods and it also seemed to some extent to prevent bacteria from entering the necrotic pulp tissue. Based on the present results it is suggested that root resorption associated with dentoalveolar ankylosis is initiated by endosteal osteoblasts and is thus a hormonally regulated process. This is in contrast to inflammatory root resorption, which seems to be triggered by inflammatory cells.

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Alkaline phosphatase activity and tetracycline incorporation during initial orthodontic tooth movement in rats

Cited by 24 publications

References 22 publications

Gingival crevicular fluid alkaline phosphatase as a potential diagnostic marker of periodontal disease

Gingival crevicular fluid alkaline phosphatase as a potential diagnostic marker of periodontal disease

General morphological aspects of resorption of teeth and alveolar bone

Dynamics of dentoalveolar ankylosis and associated root resorption

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