the melting of a source at middle crustal depths. The AP host and its enclaves from the southeastern part of the West Kunlun have low Rb, Rb/Sr (0.15-1.90) and weakly negative Eu anomalies but high HREE contents indicating limited fractionation of plagioclase without residual garnet in their source. The inferred protolith is an intermediate igneous rock in the middle or lower crust. MEs hosted in the AP have high Mg# (39.7-45.0) and Nb and weakly negative Eu anomalies, as well as high Sr, P and Ti, corresponding to a medium-K basaltic rock, which may have originated from mixing of partial melting of metasomatised mantle wedge that has been modified by upwelling asthenospheric mantle and crustal melting in the deep source. Post-collisional southeasternward younging of Mesozoic granitoids in the West Kunlun records a transition from shallow level, mid-crustal melting to deeper level, lower-crustal melting. The post-collisional granitoids show significant mantle input increasing from northwest to southeast, which was closely associated with mafic magma-driven partial melting of mantle and crustal sources as a consequence of slab break-off. Syn-to post-collisional Early Mesozoic granites emplaced along the Mazar-Kangxiwar suture zone suggest that these tectonomagmatic processes followed the closure of the Paleo-Tethys ocean during the Tarim and Karakorum-Qiangtang continental collision.