Alkaline earth metal salts of CaCO3, BaCO3, and SrCO3 as matrix for tryptophan SIMS analysis

Stupavská, Monika; Aranyosiova, M.; Velič, Dušan

doi:10.1002/sia.3503

Cited by 1 publication

(2 citation statements)

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“…Energetic aspects refer to the ability of the matrix to promote SI emission and ionization effectively due to specific collision channels in a collision cascade. Using the strategy to utilize solid matrices of bioorganics in MS applications, ionization by the alkaline earth metal salt of CaCO 3 in the presence of graphite and cellulose was investigated. It has been shown that the cellulose matrix probably inhibited and suppressed the emission of analyte ions .…”

Section: Introductionmentioning

confidence: 99%

“…Using the strategy to utilize solid matrices of bioorganics in MS applications, ionization by the alkaline earth metal salt of CaCO 3 in the presence of graphite and cellulose was investigated. It has been shown that the cellulose matrix probably inhibited and suppressed the emission of analyte ions . In this contribution, we introduced graphite in order to compare this graphite matrix with the cellulose matrix along with the effect of CaCO 3 .…”

Section: Introductionmentioning

confidence: 99%

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Matrix and primary ion‐related aspects of tryptophan SIMS analysis

Stupavská

Jerigová

Velič

2012

Surface & Interface Analysis

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Effects of different matrices and primary ions on secondary ion emission efficiency were investigated for the analysis of D-tryptophan, C 11 H 12 N 2 O 2 , using secondary ion mass spectrometry (SIMS) under impact of 25-keV Bi + and Bi 3 + . Matrix-embedded solid samples of D-tryptophan with alkaline earth metal salt of CaCO 3 were prepared in the form of pellets with either additional cellulose or graphite. In both matrices, CaCO 3 /cellulose and CaCO 3 /graphite, the ionization of D-tryptophan primarily proceeds with a loss of small functional groups or by protonation, surprisingly no Ca cationization. Using Bi + , a decreased ion yield is observed with cellulose in comparison with graphite. Interestingly, using Bi 3 + cluster-SIMS with the cellulose matrix shows enhancement of D-tryptophan molecular ions by a factor of 2, compared to the graphite matrix. The results of molecular ion yield improvement using graphite matrix support the importance of projectile type, either atomic or cluster. The differences might be explained by the matrix geometries, where cellulose forms a polymeric network compared to grains of graphite. Therefore, Bi + is less effective due to single event impact, while Bi 3 + is more effective due to larger mass and impact area within the cellulose polymeric network.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%