Alkali-Treated Alumina and Zirconia Powders Decorated with Hydroxyapatite for Prospective Biomedical Applications

Nakonieczny, Damian S.; Martynková, Gražyna Simha; Hundáková, Marianna; Kratošová, Gabriela; Holešová, Sylva; Kupková, Jana; Pazourková, Lenka; Majewska, Justyna

doi:10.3390/ma15041390

Cited by 13 publications

(13 citation statements)

References 45 publications

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“…Unfortunately, both the mechanical and physical properties of the LSR injection mold fabricated with Al-filled epoxy resins were not better than those fabricated from a conventional steel mold. Thus, enhancing both the mechanical and physical properties of an LSR injection mold by adding some different kinds of reinforcing fillers, such as carbon fibers [ 28 ], zirconia particles [ 29 ], silicon nitride particles [ 30 ], or molybdenum disulfide particles [ 31 ] in Al-filled epoxy resin is also an important research topic. The optimization of the mechanical and physical properties using the Taguchi method for an LSR injection mold could also be investigated [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Development of an Epoxy-Based Rapid Tool with Low Vulcanization Energy Consumption Channels for Liquid Silicone Rubber Injection Molding

Kuo

Tasi

Hunag³

2022

Polymers

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Liquid silicone rubber (LSR) parts have some distinct characteristics such as superior heat stability, low-temperature flexibility, aging resistance, and chemical resistance. From an industrial standpoint, the uniform vulcanization temperature of LSR is an important research point. However, the uniformity of the vulcanization temperature of LSR has been limited since the layout of the cartridge heater incorporated in the conventional steel mold does not follow the profile of the mold cavity. Metal additive manufacturing can be used to make LSR injection molds with conformal heating channels and conformal cooling channels simultaneously. However, this method is not suitable for a mold required to develop a new LSR product. In this study, a cost-effective approach was proposed to manufacture an LSR injection mold for the pilot run of a new optical lens. A rapid tool with low vulcanization energy consumption channels was proposed, which was incorporated with both a conformal heating channel (CHC) and conformal cooling channel (CCC) simultaneously. The function of the CHC was to vulcanize the LSR in the cavity uniformly, resulting in a shorter cycle time. The function of the CCC was to keep the LSR in a liquid state for reducing runner waste. It was found that the equation of y = −0.006x3 + 1.2114x2 − 83.221x + 1998.2 with the correlation coefficient of 0.9883 seemed to be an optimum trend equation for predicting the solidification time of a convex lens (y) using the vulcanizing hot water temperature (x). Additionally, the equation of y = −0.002x3 + 0.1329x2 − 1.0857x + 25.4 with the correlation coefficient of 0.9997 seemed to be an optimum prediction equation for the solidification time of a convex lens (y) using the LSR weight (x) since it had the highest correlation coefficient. The solidification time of a convex lens could be reduced by about 28% when a vulcanizing hot water temperature of 70 °C was used in the LSR injection mold with CHC.

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Section: Resultsmentioning

confidence: 99%

Development of an Epoxy-Based Rapid Tool with Low Vulcanization Energy Consumption Channels for Liquid Silicone Rubber Injection Molding

Kuo

Tasi

Hunag³

2022

Polymers

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“…It has several intriguing features, such as biocompatibility, biodegradability, osteogenesis, osteoconductivity and bioactivity, and can form direct bonds with living tissues. HAP has many different applications, for example in tissue engineering, nanomedicine, industrial catalysis and in orthopedic implant coating [ 8 , 9 ]. In this last case, it was demonstrated that the use of Ca-deficient hydroxyapatite could favour osseointegration [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…HAP has many different applications, for example in tissue engineering, nanomedicine, industrial catalysis and in orthopedic implant coating [ 8 , 9 ]. In this last case, it was demonstrated that the use of Ca-deficient hydroxyapatite could favour osseointegration [ 9 ]. HAP nano-spheres, thanks to their low solubility in physiological conditions, can be used as carriers for controlled and localized drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers

et al. 2023

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The search for effective systems to facilitate the release of poorly bioavailable drugs is a forefront topic for the pharmaceutical market. Materials constituted by inorganic matrices and drugs represent one of the latest research strategies in the development of new drug alternatives. Our aim was to obtain hybrid nanocomposites of Tenoxicam, an insoluble nonsteroidal anti-inflammatory drug, with both layered double hydroxides (LDHs) and hydroxyapatite (HAP). The physicochemical characterization on the base of X-ray powder diffraction, SEM/EDS, DSC and FT-IR measurements was useful to verify the possible hybrids formation. In both cases, the hybrids formed, but it seemed that the drug intercalation in LDH was low and, in fact, the hybrid was not effective in improving the pharmacokinetic properties of the drug alone. On the contrary, the HAP–Tenoxicam hybrid, compared to the drug alone and to a simple physical mixture, showed an excellent improvement in wettability and solubility and a very significant increase in the release rate in all the tested biorelevant fluids. It delivers the entire daily dose of 20 mg in about 10 min.

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“…Good bone repair materials should not only have a high mechanical strength but also have connected micropore structures similar to those of human bones. Related research results show that porous hydroxyapatite bone repair materials with suitable numbers and sizes of pores can provide growth space for osteoblasts and blood vessels and promote rapid bone growth [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Porous hydroxyapatite bone ceramics have good osteogenic induction properties and enhance the capacity for bone defect repair, which is more in line with the clinical requirements for biological bone repair materials.…”

Section: Introductionmentioning

confidence: 99%

3D Printing and Performance Study of Porous Artificial Bone Based on HA-ZrO2-PVA Composites

Bie¹,

Chen

Shan

et al. 2023

Materials

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An ideal artificial bone implant should have similar mechanical properties and biocompatibility to natural bone, as well as an internal structure that facilitates stomatal penetration. In this work, 3D printing was used to fabricate and investigate artificial bone composites based on HA-ZrO2-PVA. The composites were proportionally configured using zirconia (ZrO2), hydroxyapatite (HA) and polyvinyl alcohol (PVA), where the ZrO2 played a toughening role and PVA solution served as a binder. In order to obtain the optimal 3D printing process parameters for the composites, a theoretical model of the extrusion process of the composites was first established, followed by the optimization of various parameters including the spray head internal diameter, extrusion pressure, extrusion speed, and extrusion line width. The results showed that, at the optimum parameters of a spray head diameter of 0.2 mm, extrusion pressure values ranging from 1–3 bar, a line spacing of 0.8–1.5 mm, and a spray head displacement range of 8–10 mm/s, a better structure of biological bone scaffolds could be obtained. The mechanical tests performed on the scaffolds showed that the elastic modulus of the artificial bone scaffolds reached about 174 MPa, which fulfilled the biomechanical requirements of human bone. According to scanning electron microscope observation of the scaffold sample, the porosity of the scaffold sample was close to 65%, which can well promote the growth of chondrocytes and angiogenesis. In addition, c5.18 chondrocytes were used to verify the biocompatibility of the composite materials, and the cell proliferation was increased by 100% when compared with that of the control group. The results showed that the composite has good biocompatibility.

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Alkali-Treated Alumina and Zirconia Powders Decorated with Hydroxyapatite for Prospective Biomedical Applications

Cited by 13 publications

References 45 publications

Development of an Epoxy-Based Rapid Tool with Low Vulcanization Energy Consumption Channels for Liquid Silicone Rubber Injection Molding

Development of an Epoxy-Based Rapid Tool with Low Vulcanization Energy Consumption Channels for Liquid Silicone Rubber Injection Molding

Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers

3D Printing and Performance Study of Porous Artificial Bone Based on HA-ZrO2-PVA Composites

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