Alkali-metal ion/molecule association reactions and their applications to mass spectrometry

Coordination of Sodium Cation to an Oxygen Function and Olefinic Double Bond to Form Molecular Adduct Ion in Fast Atom Bombardment Mass Spectrometry.

“…In such cases, addition of an alkali metal salt to the compounds sometimes helps to induce adduct ion peaks [MϩA] ϩ (A: atomic weight of alkali metal), and these peaks have also been used for molecular weight determination in FAB mass spectrometry. [4][5][6][7] Alkali metal adduct ions of organic compounds are observed in FAB mass analyses of various compounds, especially polyoxygenated compounds such as saccharides [8][9][10][11] and polyethers, [12][13][14][15] and polyfunctional compounds such as peptides. [16][17][18][19] We previously reported the structural requirements of oxygen functional groups for stabilization of the adduct ions in FAB mass spectra of a variety of diols and related compounds with the addition of NaCl.…”

Cleavage reactions of the complex ions derived from self-complementary deoxydinucleotides and alkali-metal ions using positive ion electrospray ionization with tandem mass spectrometry

“…The affinities of alkali-metal ions with nucleobases have been investigated by both the kinetic method and threshold collision-induced dissociation mass spectrometry [2,3]. On the basis of the research work on the formation of gas-phase ion-molecule complexes, Fujii [4] concluded that the alkali-metal ion affinity generally followed the order of Li ϩ Ͼ Na ϩ Ͼ K ϩ .Various mass spectrometric methods have been used to characterize metal ion biomolecular interaction at the molecular level, to determine the site of metal ion attachment to the biomolecular and its effect on altering the properties and reactivities of the biomolecule [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. ESI-MS was shown to be an excellent means for characterizing of oligonucleotides [18,19], and provide unambiguous identification of singly and multiplycharged ions of deprotonated, protonated, and metalated oligonucleotides.…”

“…The affinities of alkali-metal ions with nucleobases have been investigated by both the kinetic method and threshold collision-induced dissociation mass spectrometry [2,3]. On the basis of the research work on the formation of gas-phase ion-molecule complexes, Fujii [4] concluded that the alkali-metal ion affinity generally followed the order of Li ϩ Ͼ Na ϩ Ͼ K ϩ .…”

Design and Performance of a Compact Li+ Ion Attachment Mass Spectrometry System with an Atmospheric Sampling Device

“…Li + ions are emitted from a small mineral bead (about 2 mm in diameter) fused to an A at an emitter current of 4.0 A, with a N 2 gas flow of 8 mL/min passing through the IS at 40 Pa and an ion multiplier gain of 3×10 3 . At a fixed pressure, the Li + ion current increases approximately linearly with the emitter current.…”

“…One of the greatest advantages of IAMS is that it can be used to directly analyze gaseous compounds. The features that allow this system to detect the intermediate free radicals and novel molecular species produced in various plasmas have been extensively explored [3][4][5], and IAMS techniques can be used to identify and quantify compounds and mixtures under plasma [6,7] and pyrolysis [8,9] conditions. To extend the ion attachment technique to ion trap mass spectrometry [10] or time of flight mass spectrometry [11] has been realized.…”