ALK-positive gastric inflammatory myofibroblastic tumor in an adult with familial adenomatous polyposis and diffuse fundic polyposis

Fan, Jun; Huang, Bo; Yang, Xiuping; Yang, Ming; He, Jun; Nie, Xiu

doi:10.1186/s13000-017-0645-0

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…[4] Most reported cases of primary gastric IMT are benign in nature. However, Jun Fan [5] reported the first gastric IMT case with metastasis in an adult. There has been controversy over whether IMT is an inflammation or tumor, benign or malignant, and its etiology and pathogenesis are still unknown.…”

Section: Discussionmentioning

confidence: 99%

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Primary gastric inflammatory myofibroblastic tumor

et al. 2018

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Rationale:Primary gastric inflammatory myofibroblastic tumor is extremely rare. Only a few cases were reported in the domestic and foreign medical literature with corresponding imaging findings of this disease even more rarely reported.Patient concerns:We present one case of a 52-year-old female patient with upper abdominal pain, acid reflux, and belching for 2 months.Diagnoses and Interventions:Electron ultrasound gastroscopy (EUS) revealed elevation of gastric antrum mucosa. A whole abdominal and pelvic multi-slice spiral computed tomography (CT) detected a round nodule in the gastric antrum with considerably delayed enhancement, with initial suspicion of gastrointestinal stromal tumors (GISTS). Then a laparoscopic assisted distal gastrectomy was performed. Finally, the postoperative pathology confirmed the diagnosis of primary gastric IMT.Outcomes:After 6 months of follow-up, the patient was still alive without any evidence of metastasis or recurrence.Lessons:Familiarizing with the CT features of this rare tumor may raise radiologists’ awareness of the disease and potentially could avoid misdiagnosis.

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Section: Discussionmentioning

confidence: 99%

“…It has been reported that some cases of IMT might be associated with genetic mutation, Epstein–Barr virus (EBV) infection or immune dysregulation. [5–8]…”

Section: Discussionmentioning

confidence: 99%

Primary gastric inflammatory myofibroblastic tumor

et al. 2018

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“… LPG, SP Negative N.D 9 months None 22 Jadhav et al [ 21 ] 2017 18 M 8.6 Gastric leiomyoma, GIST susp. PR Negative N.D 5 years None 23 Ning et al [ 22 ] 2017 50 F 3.0 Ectopic pancreas ESD N.D N.D 2 years None 24 Fan et al [ 23 ] 2017 37 M 4.5 GIST susp. TG Positive < 0.4 6 months None 25 Lee et al [ 24 ] 2018 35 F 2.5 N.D PR N.D N.D 3 years None 26 Lee et al [ 24 ] 2018 39 F 2.0 N.D PR N.D N.D ...…”

Section: Discussionmentioning

confidence: 99%

A rare case of inflammatory myofibroblast tumor of the stomach successfully treated by inverted laparoscopic and endoscopic cooperative surgery

Kimura,

Hiraki,

Akashi

et al. 2023

surg case rep

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Background An Inflammatory myofibroblastic tumor (IMT) is a rare intermediate malignancy characterized by myofibroblast proliferation and inflammatory cell infiltration. Various organs are the primary sites of origin. However, primary tumors originating in the stomach tend to be extremely rare, making the diagnosis difficult. Herein, we present a case of IMT originating in the stomach that was effectively managed using inverted laparoscopic endoscopic cooperative surgery (LECS). Case presentation A 47-year-old male who was admitted to the hospital because of a submucosal tumor that was discovered during upper gastrointestinal endoscopy. The diameter of the tumor was approximately 20 mm. A KIT-negative gastrointestinal stromal tumor was suspected based on the biopsy findings. Therefore, partial resection of the stomach was performed using inverted laparoscopic and endoscopic cooperative surgery. Histopathological examination revealed collagen fiber proliferation from the submucosal layer to the muscular layer, accompanied by infiltration of spindle-shaped cells, lymphocytes, and numerous inflammatory cells. Immunohistochemistry results were positive for SMA and negative for CD34, desmin, and c-kit. IgG4-positive cells were observed with an IgG4/IgG ratio > 50%, and specific nuclei were positive for ALK. Therefore, IMT was diagnosed. This condition may be difficult to diagnose both before and after surgery because of its rarity and submucosal tumor-like morphology. Conclusion When a submucosal tumor originating in the stomach is observed, IMT should be considered. Partial resection of the stomach with LECS and immunohistochemical diagnosis may be useful.

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“…Biological behavior has been classified as intermediate (occasional metastasis) group [7]. According to the literature, some IMT cases may be related to gene mutation, virus infection or immune system regulation [8] [9] [10] [11]. The tumor is not sensitive to radiotherapy and chemotherapy, and surgical treatment is still the main treatment.…”

Section: Discussionmentioning

confidence: 99%

Gastric Inflammatory Myofibroblastic Tumor in a 10-Year-Old Patient in Macao—Case Report and Literature Review

Man¹,

Chao²,

Fai³

2019

JCT

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Inflammatory myofibroblastic tumor (IMT) is a special type of mesenchymal tumors. The tumors can occur all over the body. The most common organs involved were lung, followed by mesentery, omentum, retroperitoneum, and pelvic cavity. But it occurs very rarely in the stomach. This article mainly reports a 10-year-old patient who complained of progressive dysphagia for 4 years. Esophagogram suggests esophageal achalasia. Abdominal CT examination revealed a huge mass with calcification in the cardiac region of stomach with metastatic lymphadenopathy. PET-CT was also performed that consistent with malignant gastric tumor with metastatic lymphadenopathy. Gastroscopy also indicated that there was a huge mass in the cardia that compressed the esophagus, and biopsy was performed to reveal chronic gastritis. Pathological analysis was performed after surgical exploration and tissue samples were taken out and the final pathology was consistent with inflammatory myofibroblastic tumors. The patient was not able to undergo surgical treatment, so crizotinib chemotherapy was used. After treatment, the patient's tumors were significantly reduced, and the effect was obvious. The patient is now in stable condition and continues to follow up. This article hopes to review the literature of imaging diagnosis of inflammatory myofibroblastic tumors through this case report, so as to improve the understanding of this disease.

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ALK-positive gastric inflammatory myofibroblastic tumor in an adult with familial adenomatous polyposis and diffuse fundic polyposis

Cited by 9 publications

References 18 publications

Primary gastric inflammatory myofibroblastic tumor

Primary gastric inflammatory myofibroblastic tumor

A rare case of inflammatory myofibroblast tumor of the stomach successfully treated by inverted laparoscopic and endoscopic cooperative surgery

Gastric Inflammatory Myofibroblastic Tumor in a 10-Year-Old Patient in Macao—Case Report and Literature Review

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