ALK-positive diffuse large B-cell lymphoma of the stomach associated with a clathrin-ALK rearrangement

McManus, Damian; Catherwood, M A; Carey, P. D.; Cuthbert, R. J. G.; Hann, Alexander

doi:10.1016/j.humpath.2004.06.001

Cited by 38 publications

(28 citation statements)

References 16 publications

(16 reference statements)

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“…Thus, ALK gene rearrangements, originally thought to be uniquely associated with T-/null cell ALCL, have now been convincingly shown to occur in rare cases of B-cell lymphoma. [2][3][4][5][6][7][8][9][10][11][12][13] Of note, prior to the initial series by Delsol et al, 1 Arber et al 17 in 1996 reported NPM/ALK fusion transcripts (by RT-PCR) in four of 33 cases of large B-cell lymphoma. Interestingly, and in contrast to the cases of ALK-DLBCL reported thus far, these four cases had a conventional B-cell immunophenotype (CD20 þ and CD79a þ ).…”

Section: -6mentioning

confidence: 99%

“…1 Recently however, Clathrin/ALK (CLTC/ALK) and NPM/ALK gene rearrangements have been identified in 16 and three cases of ALK-DLBCL, respectively. [2][3][4][5][6][7][8][9][10][11][12][13] All of these cases display the morphologic and immunophenotypic features of ALK-DLBCL, as originally described by Delsol et al Importantly, ALK positivity and ALK gene rearrangements can be seen in B-cell lymphomas and are now no longer uniquely restricted to the T-cell lymphoma, ALCL. To our knowledge, only 29 cases of ALK-DLBCL have been reported thus far in the literature.…”

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confidence: 99%

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ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature

2007

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Section: -6mentioning

confidence: 99%

mentioning

confidence: 99%

ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature

2007

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“…Up to now, 15 cases of ALK þ DLBCL have been reported in literature. [41][42][43][44][45][46][47] These cases are characterized by a distinct morphology and phenotype. The tumor is composed of a diffuse, rather monotonous proliferation of large immunoblast-or plasmablast-like cells with a plasma cell phenotype (CD20À/CD79a7/CD138 þ ) and a strong submembranous granular cytoplasmic staining for ALK.…”

Section: Alk þ Dlbclmentioning

confidence: 99%

Diffuse large B-cell lymphoma: a heterogeneous group of non-Hodgkin lymphomas comprising several distinct clinicopathological entities

2006

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Diffuse large B-cell lymphoma (DLBCL) as defined by the World Health Organization (WHO) classification is clinically, morphologically and genetically a heterogeneous group of malignant proliferations of large lymphoid B cells. Over the last 6 years, several studies have been published improving our understanding of these lymphomas. These studies analyzed DLBCL by their gene expression profile, provided further information on some of the variants of DLBCL listed in the WHO classification and stressed the impact of the site of origin of these tumors. This review summarizes these recent data and explores their impact on the recognition of new clinicopathological lymphoma entities.

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“…First, chromosomal translocation t(2;17)(p23;q23) fuses CHC17 with an intact trimerization domain (aa1-1634) to the C-terminus (aa1058-1620) of anaplastic lymphoma kinase (ALK) (40). The CHC-ALK fusion is often detected in non-Hodgkin's lymphomas and has been reported in anaplastic nul/T-cell lymphoma (41,42), large B-cell lymphoma (43)(44)(45)(46)(47)(48)(49)(50), and the rare inflammatory myofibroblastic tumor (51,52). To initiate ALKmediated lymphomagenesis, Stat3 must be activated (53).…”

Section: Oncogenic Fusionsmentioning

confidence: 99%

Novel clathrin activity: developments in health and disease

Ybe

2014

Biomolecular Concepts

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Clathrin self-assembles into a coat around vesicles filled with cargo such as nutrients, hormones, and proteins destined for degradation. Recent developments indicate clathrin is not a specialist, but is involved in different processes relevant to health and disease. Clathrin is used to strengthen centrosomes and mitotic spindles essential for chromosome segregation in cell division. In Wnt signaling, clathrin is a component of signalosomes on the plasma membrane needed to produce functional Wnt receptors. In glucose metabolism, a muscle-specific isoform, CHC22 clathrin, is key to the formation of storage compartments for GLUT4 receptor, and CHC22 dysfunction has been tied to type 2 diabetes. The activity of clathrin to self-assemble and to work with huntingtin-interacting proteins to organize actin is exploited by Listeria and enteropathic Escherichia coli in their infection pathways. Finally, there is an important connection between clathrin and human malignancies. Clathrin is argued to help transactivate tumor suppressor p53 that controls specific genes in DNA repair and apoptosis. However, this is debatable because trimeric clathrin must be made monomeric. To get insight on how the clathrin structure could be converted, the crystal structure of the trimerization domain is used in the development of the detrimerization switch hypothesis. This novel hypothesis will be relevant if connections continue to be found between CHC17 and p53 anti-cancer activity in the nucleus.

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ALK-positive diffuse large B-cell lymphoma of the stomach associated with a clathrin-ALK rearrangement

Cited by 38 publications

References 16 publications

ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature

ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature

Diffuse large B-cell lymphoma: a heterogeneous group of non-Hodgkin lymphomas comprising several distinct clinicopathological entities

Novel clathrin activity: developments in health and disease

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