ALK 1 Negative Inflammatory Myofibroblastic Tumor of the Ileum: A Rare Cause of Ileocecal Intussusception

Yagnik, Vipul D

doi:10.1055/s-0040-1710531

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…In addition, several diseases, including Crohn's disease, congenital neutropenia, gastrointestinal stromal tumor, and pregnancy have been related to the development of IMT (16). Previous studies have reported the correlation between ALK-1 gene expression and local recurrence, distant metastasis, and overall prognosis of IMT patients (17)(18)(19)(20). Moreover, in certain studies (8,21,22), the bladder IMT was associated with the Epstein-Barr virus, bacteria such as Campylobacter Equi, the human herpes virus HHV8, Campylobacter jejuni, Escherichia coli, trauma, radioand steroid therapy.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of the bladder: Computed tomographic features

et al. 2023

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Inflammatory myofibroblastic tumor (IMT) is a rare tumor with intermediate biologic potential, in which lack of understanding often poses difficulties in preoperative diagnosis and treatment. The aim of the present study was to characterize the computed tomography (CT) features of the bladder IMT. The CT images of nine pathologically confirmed bladder IMT were retrospectively reviewed. All patients underwent both unenhanced CT and contrast-enhanced CT. The diameter, location, contour, growth pattern, margin, boundary, density and enhancement pattern of the lesions were assessed. The mean Ki67 value of an irregular blood clot was 18% and that of no blood clot was 12%. A total of eight (89%) patients had one tumor and 1 (11%) patient had multiple tumors. An endophytic growth pattern was observed in 4 (44%) patients, an exophytic growth pattern in 2 (22%) patients, and a mixed growth pattern in 3 (33%) patients. The tumor manifests morphologically as either polypoid (n=5), or cauliflower-like (n=1) soft-tissue mass with a wide base in the cavity, or a limited thick-walled (n=3). The tumor margins were smooth (n=8) or lobulated (n=1), and the tumor boundaries were either clear (n=7) or ill-defined (n=2). The lesions showed either ring-shaped (n=3) or heterogeneous (n=6). The polypoid and cauliflower-like soft-tissue mass showed a symmetrical change in the center of the lesion after enhancement. The bladder IMT is mostly a single polypoid nodule in the superior wall, mostly endophytic growth, with ring-haped enhancement and symmetrical change after enhancement as its characteristic manifestations.

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Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of the bladder: Computed tomographic features

et al. 2023

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“…Toxicity and resistance in tumor cells can reduce therapy efficacy. When ALK inhibition is not an option for ALK-negative tumors, the nonsteroidal anti-inflammatory drugs (NSAIDs) have been helpful [ 16 ]. It is also postulated that NSAIDs may shrink tumors and perhaps cure cancer [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…When ALK inhibition is not an option for ALK-negative tumors, the nonsteroidal anti-inflammatory drugs (NSAIDs) have been helpful [ 16 ]. It is also postulated that NSAIDs may shrink tumors and perhaps cure cancer [ 16 ]. Corticosteroids are also effective in young children with bilateral renal-infiltrating IMT.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl

Tareen¹,

Faith²,

Waheed³

et al. 2022

Cureus

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An inflammatory myofibroblastic tumor (IMT) is an uncommon, benign tumor of myofibroblastic spindle cells. An IMT can occur in any part of the body. However, involving kidney is exceedingly rare. When this rare entity occurs in children, it becomes incredibly challenging to distinguish this rare entity from other malignancies such as Wilms tumor. Although imaging studies of the abdomen and pelvis add to the diagnosis, however, histological examination and immunohistochemical staining remain the gold standard for the precise diagnosis of this rare entity. To the best of our knowledge, only 48 cases of renal IMT have been published in the medical literature so far. We report the case of a nine-month-old girl who was brought with complaints of hematuria, and later, imaging and histological confirmation revealed an anaplastic lymphoma kinase (ALK)-negative IMT of the kidney.

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ALK 1 Negative Inflammatory Myofibroblastic Tumor of the Ileum: A Rare Cause of Ileocecal Intussusception

Cited by 2 publications

References 12 publications

Inflammatory myofibroblastic tumor of the bladder: Computed tomographic features

Inflammatory myofibroblastic tumor of the bladder: Computed tomographic features

Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl

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