Alisol B 23-acetate, a new promoter for cholesterol efflux from dendritic cells, alleviates dyslipidemia and inflammation in advanced atherosclerotic mice

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

“… 117 Recent studies have reported that Alisol B 23-acetate (23B), a new promoter for cholesterol efflux in DCs, alleviates inflammation and dyslipidemia in advanced atherosclerosis of mice, thereby controlling the atherosclerotic inflammatory state. 118 These findings expand our understanding of how DCs affect atherosclerosis and provide new potential approaches to prevent atherosclerosis.…”

Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from Alismatis Rhizoma

“…On the one hand, the lipid-lowering effects, anti-inflammatory, anti-atherosclerosis, and antidiabetic activities have been firmly established, using both in vitro and robust in vivo models. Nobody can dispute the fact that the four compounds function as regulators of lipid levels in blood [ 64 , 95 ]. The capacity of both Ali-B and Ali-B 23-acetate to attenuate and to protect from non-alcoholic steatohepatitis (NASH) has been well-established in mice models with convincing data [ 50 , 54 ].…”

“…These cumulated effects concur in reducing damages of atherosclerosis [ 52 ]. In addition, the compound exerts anti-inflammatory effects, notably an inhibition of the production of inflammatory cytokines IL-12 (interleukin-12) and IFN-γ (interferon-γ), also contributing to the anti-atherosclerotic effect [ 64 ]. The capacity of Ali-B 23-acetate to markedly reduce the atherosclerotic plaque area and lipid accumulation is most likely the resultant of a cumulative effect implicating FXR agonism, anti-inflammatory effects and regulation of cholesterol synthesis and export ( Figure 4 ).…”

The roles of serine hydrolases and serum albumin in alisol B 23-acetate hydrolysis in humans

“…Previous studies have suggested that Rhizoma Alismatis contains a variety of constituents including terpenoids, sterols, glycosides, and flavonoids, while triterpenoids have been reported as the major active constituents ( Liu et al, 2020 ; Bailly C., 2022 ). Among all reported terpenoids in Rhizoma Alismatis , Alisol B 23-acetate has drawn much attention in the past few decades, owing to its high abundance and broad pharmacological activities ( Kwon et al, 2021 ; Sun et al, 2021 ). Consequently, the Chinese Pharmacopoeia of the 2020 edition has recommended that alisol B 23-acetate (AB23A) and alisol C 23-acetate should be used as the maker compounds for quality control of Rhizoma Alismatis .…”