Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway

Ho, Chia-Kang; Gao, Ya; Zheng, Duo; Liu, Yanjun; Shan, Shengzhou; Fang, Bin; Zhao, Yixuan; Song, Dingzhong; Zhang, Yifan; Li, Qingfeng

doi:10.1111/jcmm.14380

Cited by 45 publications

(32 citation statements)

References 51 publications

(83 reference statements)

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“…In the human hepatic stellate cell line LX-2 cells modeled with MCD medium, Alisol A can regulate autophagy via the AMPK/mTOR/ULK1 pathway, it can also suppress reactive oxygen species (ROS) and inflammation in MCD mouse model [ 46 ]. Besides that, Alisol A cannot alleviate lipid and glucose metabolism, but also reduce hepatic steatosis and improve liver function in HFD mice [ 47 ]. In vitro, AA24A significantly reduces the number of lipid droplets, oil red O lipid content and triglyceride (TG) content in cells treated with palmitic acid [ 48 ].…”

Section: Effects and Mechanisms Of Commonly Used Single Herb Drugs In Tcm On Nafldmentioning

confidence: 99%

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

et al. 2021

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Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM’s holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease. However, the multi-compounds and multi-targets are big obstacle for the study of TCM. Here, we summarize the pharmacological actions of active ingredients from frequently used single herbs in TCM compounds. The combined mechanism of herbs in TCM compounds are further discussed to explore their comprehensive effects on NAFLD. This article aims to summarize multiple functions and find the common ground for TCM treatment on NAFLD, thus providing enrichment to the scientific connotation of TCM theories and promotes the exploration of TCM therapies on NAFLD.

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Section: Effects and Mechanisms Of Commonly Used Single Herb Drugs In Tcm On Nafldmentioning

confidence: 99%

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

et al. 2021

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“…It remains to be explored whether these actions of alisol A are mediated by activation of PPARa and PPARd. It was reported that alisol A can activate the phosphorylation of AMPK (Ho et al, 2019). AMPK reduces lipid accumulation by regulating the expression of PPARa (Chen et al, 2013;Kang et al, 2015), whereas histone deacetylase SIRT1 senses the level of energy and helps cells to resist external stress and improve metabolism (Stein and Matter, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The 5'-adenosine monophosphate-activated protein kinase (AMPK) has been reported as an important regulator of cell metabolism (Fisslthaler and Fleming, 2009). It exerts anti-atherosclerotic action through reducing the activation of NF-kB (Li et al, 2020), promoting phosphorylation of acetyl-CoA carboxylase (ACC) to inhibit liver lipid synthesis (Ho et al, 2019), and inhibiting mTOR to enhance autophagy of macrophages (Yang et al, 2018). In addition, activation of AMPK increases intracellular nicotinamide adenine dinucleotide (NAD+) levels and activates Sirtuin 1(SIRT1) to protect the heart (Cantoé t al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Alisol A Alleviates Arterial Plaque by Activating AMPK/SIRT1 Signaling Pathway in apoE-Deficient Mice

et al. 2020

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Alismatis Rhizoma (zexie), an herb used in traditional Chinese medicine, exhibits hypolipemic, anti-inflammation and anti-atherosclerotic activities. Alisol A is one of the main active ingredients in Alismatis Rhizoma extract. In this study, we investigate the role of alisol A in anti-atherosclerosis (AS). Our study demonstrated that alisol A can effectively inhibit the formation of arterial plaques and blocked the progression of AS in ApoE −/− mice fed with high-fat diet and significantly reduced the expression of inflammatory cytokins in aorta, including ICAM-1, IL-6, and MMP-9. In addition, we found that alisol A increased the expression of PPARa and PPARd proteins in HepG2 cells and in liver tissue from ApoE −/− mice. Alisol A activated the AMPK/SIRT1 signaling pathway and NF-kB inhibitor IkBa in HepG2 cells. Our results suggested that alisol A is a multi-targeted agent that exerts anti-atherosclerotic action by regulating lipid metabolism and inhibiting inflammatory cytokine production. Therefore, alisol could be a promising lead compound to develop drugs for the treatment of AS.

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“…), Lycium barbarum polysaccharide, Jatrorrhizine hydrochloride, oxyresveratrol, and alisol A isolated from Rhizoma alismatis (Oriental Waterplantain Tuber.) attenuated liver steatosis in HFD-fed animals via regulating lipogenic genes, predominantly relating with downregulation of SREBP-1c expression via AMPK activation Li W. et al, 2014;Lee Y. H. et al, 2016;Yang et al, 2016;Lee et al, 2018;Lim et al, 2018;Ho et al, 2019). Gangjihwan, a polyherbal composition of Ephedra intermedia Schrenk & C.A.Mey., Lithospermum erythrorhizon Siebold & Zucc., and Rheum palmatum L., showed anti-obesity and antinonalcoholic steatohepatosis effects in HFD-fed mice.…”

Section: Reducing Hepatic De Novo Lipogenesismentioning

confidence: 99%

The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism

Guo

et al. 2020

Front. Pharmacol.

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The dysregulation of hepatic lipid metabolism is one of the hallmarks in many liver diseases including alcoholic liver diseases (ALD) and non-alcoholic fatty liver diseases (NAFLD). Hepatic inflammation, lipoperoxidative stress as well as the imbalance between lipid availability and lipid disposal, are direct causes of liver steatosis. The application of herbal medicines with anti-oxidative stress and lipid-balancing properties has been extensively attempted as pharmaceutical intervention for liver disorders in experimental and clinical studies. Although the molecular mechanisms underlying their hepatoprotective effects warrant further exploration, increasing evidence demonstrated that many herbal medicines are involved in regulating lipid accumulation processes including hepatic lipolytic and lipogenic pathways, such as mitochondrial and peroxisomal b-oxidation, the secretion of very low density lipoprotein (VLDL), the non-esterified fatty acid (NEFA) uptake, and some vital hepatic lipogenic enzymes. Therefore, in this review, the pathways or crucial mediators participated in the dysregulation of hepatic lipid metabolism are systematically summarized, followed by the current evidences and advances in the positive impacts of herbal medicines and natural products on the lipid metabolism pathways are detailed. Furthermore, several herbal formulas, herbs or herbal derivatives, such as Erchen Dection, Danshen, resveratrol, and berberine, which have been extensively studied for their promising potential in mediating lipid metabolism, are particularly highlighted in this review. FIGURE 1 | Major processes involved in hepatic lipid metabolism. Li et al.

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Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway

Cited by 45 publications

References 51 publications

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

Alisol A Alleviates Arterial Plaque by Activating AMPK/SIRT1 Signaling Pathway in apoE-Deficient Mice

The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism

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