Alimentary Granulomata and the Immune Response

A study of Crohn's syndrome using tissue extracts and the Kveim and Mantoux tests.

“…Koffler, Minkowitz, Rothman, and Garlock (1962) also failed to demonstrate antibodies in 25 cases of Crohn's disease, using the indirect fluorescent technique. Although it is often maintained (Slaney, 1961) that the granulomatous component of Crohn's syndrome is an expression of hypersensitivity and possibly of autoimmunity, at the moment there is no definite proof.…”