Alignment of collagen matrices using magnetic nanowires and magnetic barcode readout using first order reversal curves (FORC) (invited)

Sharma, Anirudh; DiVito, Michael D.; Shore, Daniel; Block, Andrew D.; Pollock, Katie; Sølheid, P.; Feinberg, Joshua M.; Modiano, Jaime F.; Lam, Cornelius H.; Hubel, Allison; Stadler, Bethanie J. H.

doi:10.1016/j.jmmm.2017.11.035

Cited by 19 publications

(12 citation statements)

References 26 publications

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“…[42] Similarly, Sharma et al prepared bi-directionally oriented collagen matrices by application of a magnetic field to suspensions of magnetic nanowires in solutions of collagen during their fixation. [43] The observed bi-directional alignment was even transferred to arachnoid cells cultured in the aligned collagen matrices. More recently, Shi et al reported the preparation of anisotropic collagen hydrogels by magnetic field-induced alignment of SiO2@Fe3O4 rods embedded within the pre-gel solution.…”

Section: Cell Viability Assessmentmentioning

confidence: 97%

In vitro characterization of a novel magnetic fibrin-agarose hydrogel for cartilage tissue engineering

Bonhome-Espinosa

Campos

Durand‐Herrera

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

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The encapsulation of cells into biopolymer matrices enables the preparation of engineered substitute tissues. Here we report the generation of novel 3D magnetic biomaterials by encapsulation of magnetic nanoparticles and human hyaline chondrocytes within fibrin-agarose hydrogels, with potential use as articular hyaline cartilage-like tissues. By rheological measurements we observed that, (i) the incorporation of magnetic nanoparticles resulted in increased values of the storage and loss moduli for the different times of cell culture; and (ii) the incorporation of human hyaline chondrocytes into nonmagnetic and magnetic fibrin-agarose biomaterials produced a control of their swelling capacity in comparison with acellular nonmagnetic and magnetic fibrinagarose biomaterials. Interestingly, the in vitro viability and proliferation results showed that the inclusion of magnetic nanoparticles did not affect the cytocompatibility of the biomaterials. What is more, immunohistochemistry showed that the inclusion of magnetic nanoparticles did not negatively affect the expression of type II collagen of the human hyaline chondrocytes. Summarizing, our results suggest that the generation of engineered hyaline cartilage-like tissues by using magnetic fibrin-agarose hydrogels is feasible. The resulting artificial tissues combine a stronger and stable mechanical response, with promising in vitro cytocompatibility. Further research would be required to elucidate if for longer culture times additional features typical of the extracellular matrix of cartilage could be expressed by human hyaline chondrocytes within magnetic fibrinagarose hydrogels.

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Section: Cell Viability Assessmentmentioning

confidence: 97%

In vitro characterization of a novel magnetic fibrin-agarose hydrogel for cartilage tissue engineering

Bonhome-Espinosa

Campos

Durand‐Herrera

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

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“…11,[17][18][19][20][21] An external eld can be remotely used to physically excite MNWs, which makes them suitable for cell tracking, [22][23][24][25] cells manipulation, 26 cell separation, 27,28 drug delivery and drug activation, 29,30 magnetic hyperthermia, 21 and magneto-elastic ferrogels for tissue engineering. 31,32 Furthermore, the MNWs have shown a high internalization by cells in comparison to other magnetic nanoparticles, such as IONs, improving the enrichment and multiplexing yield. 26,28,33 As a consequence, MNWs have recently attracted attention as enrichment agents for studying breast and lung cancers, 34,35 CTCs, 36 and leukemia.…”

Section: Introductionmentioning

confidence: 99%

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

Kouhpanji

Stadler

2020

RSC Adv.

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“…To overcome this limitation, Sharma et al proposed crosslinking the collagen fibrils with surface functionalized magnetic nanowires prior to gelation. Using this technique, they showed that one-step bi-directional alignment of the collagen fibrils using only a few hundred Oersted [175] (Figure 19). Magnetic nanoparticles are also incorporated into hydrogels for producing ferrogels by chemically crosslinking the magnetic nanoparticles to the hydrogels.…”

Section: Tissue Engineeringmentioning

confidence: 99%

A Guideline for Effectively Synthesizing and Characterizing Magnetic Nanoparticles for Advancing Nanobiotechnology: A Review

Kouhpanji

Stadler

2020

Sensors

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The remarkable multimodal functionalities of magnetic nanoparticles, conferred by their size and morphology, are very important in resolving challenges slowing the progression of nanobiotechnology. The rapid and revolutionary expansion of magnetic nanoparticles in nanobiotechnology, especially in nanomedicine and therapeutics, demands an overview of the current state of the art for synthesizing and characterizing magnetic nanoparticles. In this review, we explain the synthesis routes for tailoring the size, morphology, composition, and magnetic properties of the magnetic nanoparticles. The pros and cons of the most popularly used characterization techniques for determining the aforementioned parameters, with particular focus on nanomedicine and biosensing applications, are discussed. Moreover, we provide numerous biomedical applications and highlight their challenges and requirements that must be met using the magnetic nanoparticles to achieve the most effective outcomes. Finally, we conclude this review by providing an insight towards resolving the persisting challenges and the future directions. This review should be an excellent source of information for beginners in this field who are looking for a groundbreaking start but they have been overwhelmed by the volume of literature.

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Alignment of collagen matrices using magnetic nanowires and magnetic barcode readout using first order reversal curves (FORC) (invited)

Cited by 19 publications

References 26 publications

In vitro characterization of a novel magnetic fibrin-agarose hydrogel for cartilage tissue engineering

In vitro characterization of a novel magnetic fibrin-agarose hydrogel for cartilage tissue engineering

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

A Guideline for Effectively Synthesizing and Characterizing Magnetic Nanoparticles for Advancing Nanobiotechnology: A Review

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