Aligned electrospun nanofibers for ultra-thin layer chromatography

Beilke, Michael C.; Zewe, Joseph W.; Clark, Jonathan E.; Olesik, Susan V.

doi:10.1016/j.aca.2012.11.028

Cited by 43 publications

(41 citation statements)

References 28 publications

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“…As shown in Figure 3, the electrospun silica films have a low density per unit area, so the dye molecules may diffuse to a greater extent while in the mobile phase in between adsorption events on the stationary phase, as compared to commercial plates composed of close packed silica particles. Beilke et al reports that low nanofiber mat density (as determined in their work by mass differences of mats with the same thickness) results in band broadening and overall poor chromatographic performance (14). Another possible explanation is that the dye molecules follow the trajectory of the electrospun fibers as they adsorb and desorb from the silica during the separation.…”

Section: Resultsmentioning

confidence: 95%

“…Porous and textured nanofibers as well as beaded nanofibers can be produced by incorporating particles in the electrospinning solution (3,(10)(11)(12) or varying the electrospinning solution viscosity (9,13). In addition, specially designed collector plate electrodes (2) and rotating collector drums (14) can be used to prepare oriented nanofiber mats. Electrospun fibers have found application in a number of fields, from catalysis (15)(16)(17)(18), chemical sensing (16,19), separations (14,(20)(21)(22)(23)(24) to biomaterials (6,10,25,26).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, specially designed collector plate electrodes (2) and rotating collector drums (14) can be used to prepare oriented nanofiber mats. Electrospun fibers have found application in a number of fields, from catalysis (15)(16)(17)(18), chemical sensing (16,19), separations (14,(20)(21)(22)(23)(24) to biomaterials (6,10,25,26). In each case, the morphology of the electrospun fibers have played an important role in the material's ultimate utility in its application.…”

Section: Introductionmentioning

confidence: 99%

“…Working primarily with polyacrylonitrile (PAN), they demonstrated that these electrospun stationary phases have faster analysis times and efficiencies 10 times higher than commercial TLC plates. When the electrospun fibers are aligned, by collecting fibers on a rotating drum (14), the performance of the electrospun plate improves further, with efficiencies 100 times greater then the unaligned PAN stationary phase and faster separations. Furthermore, the R f values were more consistent (lower % relative standard deviation) for aligned vs. non-aligned electrospun TLC plates (14).…”

Section: Introductionmentioning

confidence: 99%

“…When the electrospun fibers are aligned, by collecting fibers on a rotating drum (14), the performance of the electrospun plate improves further, with efficiencies 100 times greater then the unaligned PAN stationary phase and faster separations. Furthermore, the R f values were more consistent (lower % relative standard deviation) for aligned vs. non-aligned electrospun TLC plates (14). Other researchers have continued to explore this material's preparation route for stationary phases, incorporating additives in PAN films to create TLC plates with photoluminescent detection (24).…”

Section: Introductionmentioning

confidence: 99%

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Electrospun Silica Nanofiber Mats

Freyer

Savage

2014

ACS Symposium Series

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Electrospun nanofiber mats were prepared from low-viscosity sol-gel silica without the addition of a carrier polymer. Silica sols synthesized from tetraethyl orthosilicate (TEOS) under acidic conditions were electrospun into nanofibers in the viscosity range of 2 to 4 mPa·s. The influence of ethanol and water concentrations on the viscosity of as-synthesized and aged silica sols was also determined. Nanofibers produced from as-synthesized sols with a TEOS:H 2 O ratio of 1:2 ranged in diameter from 50 nm to 200 nm. Increases in viscosity, whether due to aging or increased water concentration in the sol resulted in fragmented nanofibers. Nanofiber mats used as the stationary phase for thin layer chromatography (TLC) were able to separate components of a test dye mixture.

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrospun Silica Nanofiber Mats

Freyer

Savage

2014

ACS Symposium Series

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Nanomaterials as stationary phases and supports in liquid chromatography

et al. 2017

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The development of various nanomaterials over the last few decades has led to many applications for these materials in liquid chromatography (LC). This review will look at the types of nanomaterials that have been incorporated into LC systems and the applications that have been explored for such systems. A number of carbon-based nanomaterials and inorganic nanomaterials have been considered for use in LC, ranging from carbon nanotubes, fullerenes and nanodiamonds to metal nanoparticles and nanostructures based on silica, alumina, zirconia and titanium dioxide. Many ways have been described for incorporating these nanomaterials into LC systems. These methods have included covalent immobilization, adsorption, entrapment, and the synthesis or direct development of nanomaterials as part of a chromatographic support. Nanomaterials have been used in many types of LC. These applications have included the reversed-phase, normal-phase, ion-exchange, and affinity modes of LC, as well as related methods such as chiral separations, ion-pair chromatography and hydrophilic interaction liquid chromatography. Both small and large analytes (e.g., dyes, drugs, amino acids, peptides and proteins) have been used to evaluate possible applications for these nanomaterial-based methods. The use of nanomaterials in columns, capillaries and planar chromatography has been considered as part of these efforts. Potential advantages of nanomaterials in these applications have included their good chemical and physical stabilities, the variety of interactions many nanomaterials can have with analytes, and their unique retention properties in some separation formats.

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A high‐performance multifunctional substrate of ultrathin‐layer chromatography (UTLC) and surface‐enhanced Raman scattering (SERS) for rapid biochemical mixture screening

Lee

Lin

Huang

et al. 2018

J Raman Spectroscopy

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We present a multifunctional substrate of ultrathin‐layer chromatography (UTLC) and surface‐enhanced Raman scattering (SERS), which enables analytes separation and label‐free detection simultaneously. This integrated substrate is composed of silicon nanowires array (SiNWA), decorated with silver nano‐dendrites (AgNDs). This SiNWA is fabricated by a facile and low‐cost metal‐assisted chemical etching process, and the AgNDs are then decorated onto SiNWA by chemical reduction process. These AgNDs provide abundant hot spots by inducing strong localized electric field, which is confirmed by finite‐difference time‐domain simulation calculations. With the optimized multifunctional substrate, the screening of melamine is successfully validated. The high linear dependence of signal intensity and melamine concentrations from 15 to 1,500 ppm with small deviation was carried out by our developed UTLC–SERS substrate, providing a great potential for quantitative detection. Besides, the SERS signals further show a low relative standard deviation of 8.7%, benefited from the calibration by a peak located at 520 cm−1 of silicon. In short, such a low‐cost, high‐stable multifunctional substrate of UTLC and SERS can be readily employed for practical applications of rapid biochemical mixture screening.

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Aligned electrospun nanofibers for ultra-thin layer chromatography

Cited by 43 publications

References 28 publications

Electrospun Silica Nanofiber Mats

Electrospun Silica Nanofiber Mats

Nanomaterials as stationary phases and supports in liquid chromatography

A high‐performance multifunctional substrate of ultrathin‐layer chromatography (UTLC) and surface‐enhanced Raman scattering (SERS) for rapid biochemical mixture screening

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