Aligned core/shell electrospinning of poly(glycerol sebacate)/poly(<scp><b>l</b></scp>‐lactic acid) with tuneable structural and mechanical properties

Xu, Bing; Cook, Wayne D.; Zhu, Chenghao; Chen, Qizhi

doi:10.1002/pi.5071

Cited by 7 publications

(6 citation statements)

References 49 publications

(94 reference statements)

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“…Also, in this case, a prepolymer is used for the synthesis. This form, as well as the cross-linked polymer, is more and more willingly used in electrospinning techniques. − All of these contribute to the knowledge about the synthesis of PGS prepolymer underlying further research; this work is therefore extremely necessary and can indirectly help in achieving future intended applications of tissue engineering. The kinetics of poly(glycerol sebacate) polycondensation is still interesting and cited in most of the recent articles, which confirms the importance of this issue. , …”

Section: Introductionsupporting

confidence: 65%

Kinetics of Polycondensation of Sebacic Acid with Glycerol

Matyszczak

Wrzecionek

Gadomska‐Gajadhur

et al. 2020

Org. Process Res. Dev.

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Based on the measurement of infrared spectra carried out during the polycondensation of sebacic acid with glycerol at temperatures of 130, 150, and 170 °C, a kinetic model was created that was in very good agreement with the experimental data. The kinetic model consists of elementary reactions and their kinetic rate constants. The energy of activation of elementary reactions was determined. The numerical solution of the system of differential equations based on elementary reactions of the model allows prediction of changes in considerations of reagents over time and an approximate estimation of the molar mass distribution of polymers in the reaction product. The results of the simulations are in line with the results of the testing experiments and allow us to optimize the course of the reaction, among others, to determine the reaction time to the desired conversion of monomers at a specific size distribution in the product. This is the first work to determine the kinetics of polycondensation of sebacic acid with glycerol based on a kinetic model.

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Section: Introductionsupporting

confidence: 65%

Kinetics of Polycondensation of Sebacic Acid with Glycerol

Matyszczak

Wrzecionek

Gadomska‐Gajadhur

et al. 2020

Org. Process Res. Dev.

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“…Recently, PGS fibrous membranes were fabricated by coaxial electrospinning and blend electrospinning . PGS fibrous membranes with varying degrees of fiber alignment were also realized . Unlike conventional electrospinning, the methods used in these studies are technically demanding and require significant amount of work on optimizing operating conditions.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a mechanically anisotropic poly(glycerol sebacate) membrane for tissue engineering

et al. 2017

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Poly(glycerol sebacate) (PGS) has been used successfully as a scaffolding material for soft tissue engineering. PGS scaffolds, however, are usually mechanically isotropic, which may restrict their use in tissue repairs as many soft tissues in the body have anisotropic mechanical behaviors. Although various methods have been used to fabricate anisotropic scaffolds, it remains challenging to make anisotropic scaffolds from thermoset PGS. Here a new, simple method to fabricate an anisotropic PGS membrane which can then be used to construct thicker three-dimensional anisotropic scaffolds was developed. First, an aligned sacrificial poly(vinyl alcohol) fibrous membrane was prepared by electrospinning. The fibrous membrane was then partially immersed in PGS prepolymer solution, resulting in a composite membrane upon drying. After curing, the sacrificial fibers within the membrane were removed by water, supposedly leaving aligned cylindrical pores in the membrane. Both SEM and AFM illustrated aligned grooves on the surface of the resultant PGS membrane, indicating the successful removal of sacrificial fibers. The PGS membrane was validated to be mechanically anisotropic using uniaxial tensile testing along and perpendicular to the predominant pore direction. The in vitro cytocompatibility of the PGS membrane was confirmed. As a demonstration of its potential application in vascular tissue engineering, a tubular scaffold was constructed by wrapping a stack of two axisymmetric pieces of the anisotropic PGS membranes on a mandrel. The compliance of the scaffold was found to depend on the pitch angle of its double helical structure, imitating the anisotropic mechanical behavior of the arterial media. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 760-770, 2018.

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“…The mechanical properties of the materials were investigated, and as typically seen in aligned fiber systems, significant increases in failure stress and modulus and a reduction in failure strain were seen when materials were loaded in the fiber direction, as the large majority of fibers are directly loaded and recruited to resist the applied strain, with less capacity for fiber reorganization under loading …”

Section: Resultsmentioning

confidence: 99%

Guided Cell Attachment via Aligned Electrospinning of Glycopolymers

Liu

Becer

Screen

2018

Macromolecular Bioscience

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The creation of biomaterials with aligned fibers offers broad applications in tissue regeneration, guiding cell organization and physiological cues, and providing appropriate mechanical properties for many biomedical applications. Herein, for the first time, highly aligned electrospun membranes are designed and developed using glycopolymers. The membranes retain the strong mechanical properties of polycaprolactone, and fiber alignment facilitates the creation of anisotropic mechanical properties, enabling failure stress to be manipulated by an order of magnitude relative to randomly ordered fibers. Biocompatibility and cell attachment in these materials are characterized using tenocytes as a cell model. Both random and aligned fiber glycopolymers show promising biocompatibility, but aligned glycopolymer fibers additionally offer patterning to guide cell organization. These materials potentially provide a novel platform for tissue regeneration studies, demonstrating that the sugar–lectin interaction can produce materials capable of managing cell guidance.

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Aligned core/shell electrospinning of poly(glycerol sebacate)/poly(l‐lactic acid) with tuneable structural and mechanical properties

Cited by 7 publications

References 49 publications

Kinetics of Polycondensation of Sebacic Acid with Glycerol

Kinetics of Polycondensation of Sebacic Acid with Glycerol

Fabrication of a mechanically anisotropic poly(glycerol sebacate) membrane for tissue engineering

Guided Cell Attachment via Aligned Electrospinning of Glycopolymers

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