Alhagi maurorum: A convenient source of lupeol

Laghari, Abdul Hafeez; Memon, Shahabuddin; Nelofar, Aisha; Khan, Khalid Mohammed

doi:10.1016/j.indcrop.2011.03.031

Cited by 55 publications

(25 citation statements)

References 21 publications

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“…Lupeol (1) 03,43.04,42.86,40.86,38.90 y 37.20 ppm;seis CH en δH: 79.04,55.32,50.46,48.33,48.02 y 38.08 ppm;once CH2 en δH: 40.03,38.73;35.61,34.30,29.87,29.73,27.46;25.16,20.96,18.35 ppm y δ 109.36 ppm característico de un carbono metilénico olefínico; siete CH3 en δH: 28. 02, 19.34, 18.04, 16.15, 16.01, 15.40 y 14.58 ppm; COSY: δ 4.68 con δ 4.56 ppm, δ 3.18 con δ 1.68 ppm, δ 4.68 con δ 1.68 ppm (Laghari et al, 2011).…”

Section: Resultados Y Discusiónmentioning

confidence: 99%

Estudio Fitoquímico y Evaluación de la Actividad Antioxidante y Leishmanicida de la Especie Pilocarpus alvaradoi (Rutaceae)

et al. 2018

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Autor a quien debe ser dirigida la correspondencia ResumenSe realizó el estudio fitoquímico y se evaluó la actividad antioxidante y leishmanicida de la especie Pilocarpus alvaradoi. La identificación de los compuestos se realizó mediante el análisis de datos de RMN-1 H, 13 C y EM. La actividad antioxidante se evaluó usando los métodos DPPH • y ABTS •+ ; el potencial leishmanicida in vitro fue medido frente a cepas de Leishmania (V) panamensis mediante citometría de flujo y la citotoxicidad por el método MTT. De esta especie se aislaron e identificaron seis compuestos: una cumarina, un alcaloide, tres esteroles y un ácido graso. El extracto etanólico de corteza mostró baja citotoxicidad con una CL50 de 70.5 µg/ml y un buen potencial leishmanicida con una CE50 de 30.7 µg/ml comparado con la Anfotericina B. Los extractos de Pilocarpus alvaradoi constituyen una importante fuente de metabolitos con actividad biológica; y las sustancias obtenidas son reportadas por primera vez para esta especie. AbstractThe phytochemical study was carried out and the antioxidant and leishmanicidal activity of the Pilocarpus alvaradoi species was evaluated. Identification of the compounds was performed by the analysis of NMR-1 H, 13 C and MS data. Antioxidant activity was assessed using the DPPH • and ABTS •+ methods; the leishmanicidal potential in vitro was measured against strains of Leishmania (V) panamensis by flow cytometry and cytotoxicity by the MTT method. Of this species, six compounds were isolated and identified: a coumarin, an alkaloid, three sterols and a fatty acid. The ethanolic bark extract showed low cytotoxicity with a CL50 of 70.5 μg/ml and a good leishmanicidal potential with an EC50 of 30.7 μg/ml compared to amphotericin B. The extracts of Pilocarpus alvaradoi constitute an important source of metabolites with biological activity; and the substances obtained are reported for the first time for this specie.

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Section: Resultados Y Discusiónmentioning

confidence: 99%

Estudio Fitoquímico y Evaluación de la Actividad Antioxidante y Leishmanicida de la Especie Pilocarpus alvaradoi (Rutaceae)

et al. 2018

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“…In this study, the aerial parts of V. blumeoides has yielded four novel eudesmanolides (1-4) in addition to the known compounds, chrysin (5) and apigenin (6) (Wawer and Zielinska, 2001), luteolin (7) (Li et al, 2008), stigmasterol (8) (Forgo and Kövér, 2004) and lupeol (9) (Laghari et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria

et al. 2015

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“…), along with four known terpenoids from the roots of A. maurorum (Hamid et al , ). A recent article has shown the presence of bioactive terpenoid lupeol (0.11 g), as the principal component in the root bark (100 g) of A. maurorum (Laghari et al , ). Because of the presence of a wide array of terpene glycosides, extracts of A. maurorum could be explored as a potential candidate to isolate novel antiproliferative agents.…”

Section: Phytochemistrymentioning

confidence: 99%

“…Temperature decrease was found to be 2.2, 2.4 and 3.2 °C for 250, 500 and 1000 mg/kg of body weight of rats after 30 min (Marashdah and Farraj, ). Moreover, an anti‐inflammatory tripterpenoid lupeol (Nguemfo et al , ; Nikiéma et al , ; Sudhahar et al , ) was isolated by Laghari et al () from n ‐hexane fraction of methanolic extract of root bark of A. maurorum by eluting it with 20% EtOAc (Laghari et al , ). As there is clear evidence that the Alhagi plants possess a combination of analgesic, antipyretic and anti‐inflammatory activities, potential thus exists for the development of some safer natural anti‐inflammatory and pain killers from this species.…”

Section: Pharmacological Attributesmentioning

confidence: 99%

Alhagi: A Plant Genus Rich in Bioactives for Pharmaceuticals

Muhammad

Hussain

Anwar

et al. 2014

Phytotherapy Research

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Alhagi, a plant genus from family Fabaceae, is widely distributed in many countries of Asia, Australia and Europe. Commonly known as camel thorn, Alhagi has many species famous for feed and folk medicinal uses. Different species of Alhagi such as Alhagi pseudalhagi, A. graecorum, A. sparsifolia, A. kirgisorum, A. maurorum, A. camelorum and A. persarum have been explored for their antioxidant potential and nutritive value along with various medicinal properties. A wide array of pharmacologically active secondary metabolites such as flavonoids, alkaloids (alhacidin and alhacin), steroids, pseudalhagin A, phospholipids and polysaccharides have been reported from different parts of Alhagi species. A broad range of biological activities such as antioxidant, cardiovascular, anti-ulcer, hepatoprotective, antispasmodic, antidiarrheal, antinociceptive, antipyretic, anti-inflammatory, anti-rheumatic, antibacterial and antifungal have been ascribed to different parts of Alhagi. In addition, Alhagi plants are also valued as a rich source of digestible protein and important minerals. This review focuses on the medicinal applications and detailed profile of high-value bioactive phytochemicals along with pharmacological attributes and therapeutic potential of these multi-purpose plants.

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Alhagi maurorum: A convenient source of lupeol

Cited by 55 publications

References 21 publications

Estudio Fitoquímico y Evaluación de la Actividad Antioxidante y Leishmanicida de la Especie Pilocarpus alvaradoi (Rutaceae)

Estudio Fitoquímico y Evaluación de la Actividad Antioxidante y Leishmanicida de la Especie Pilocarpus alvaradoi (Rutaceae)

Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria

Alhagi: A Plant Genus Rich in Bioactives for Pharmaceuticals

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