“…Discussion : Caruso et al wrote a detailed review of the evidence for prophylactic antibiotic therapy in traumatic craniomaxillofacial injuries in 2022, nicely summarizing the available literature. 4 Much of this discussion will draw from that review, as well as the Infectious Disease Society of America guidelines. 29 There is a general lack of adequate evidence to guide decision-making for these injuries, and Caruso et al appropriately counsel that thoughtful consideration of the patient, wound, and underlying pathophysiology must be used to make decisions when there is no clear guidance from the data.…”