Algorithmic and heuristic strategies in comprehension of complement clauses by patients with Parkinson's disease

Natsopoulos, Dimitris; Grouios, George; Bostantzopoulou, Sevasti; Mentenopoulos, G.; Katsarou, Zoe; Logothetis, John

doi:10.1016/0028-3932(93)90150-x

Cited by 52 publications

(33 citation statements)

References 61 publications

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“…Note that even if the initial concept of grammatical movement has been revised in more recent theories, the notion of grammatical transformation always holds a central role in almost all models of generative grammar. When studying this canonical versus non-canonical contrast several studies have shown that PD patients have difficulties interpreting non-canonical word order whereas they have near normal performance on canonical structures, such as actives and subject-relatives (Kemmerer, 1999;McNamara, Krueger, O'Quin, Clark, & Durso, 1996;Natsopoulos et al, 1993). Similar results were reported in early stages of HD.…”

Section: Introductionsupporting

confidence: 57%

“…At first view, this supports the broad claim that the striatum is involved in the computation of language rules (Ullman, 2001) extending evidence from the word domain (Teichmann et al, 2005;Ullman et al, 1997) to the domain of phrasal structures. However, the striatum seems to subserve complex movement rules in syntax (see also Kemmerer, 1999;McNamara et al, 1996;Natsopoulos et al, 1993), whereas it was claimed to impact on more basic default rules in word morphology (Ullman et al, 1997). Thus, assuming that both complex and default rules represent genuine language rules in that they intervene whenever linguistic memory fails (Jackendoff, 2002;Pinker, 1999), the striatum appears to underpin distinct rule computations in distinct language domains.…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, it may be argued that, independent from the language domain, the striatum impacts on both complex and default rules, yet at different degrees. Indeed, several studies have shown that striatal damage prominently impairs the computation of complex and infrequent rules, such as syntactic movement (Kemmerer, 1999;McNamara et al, 1996;Natsopoulos et al, 1993;Teichmann et al, 2005) and morphological sub-regularities (Teichmann et al, 2005), while more automated default rules are more mildly affected (Teichmann, Dupoux, Kouider, & Bachoud-Lévi, 2006). Alternatively, it has been proposed that striatal damage mainly impacts on default rules, leading to excessive rule use in HD patients, who were shown to over-regularise during verb conjugation producing forms like dig-ed (from to dig) instead of dug (Ullman et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

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The role of the striatum in sentence processing: Evidence from a priming study in early stages of Huntington's disease

et al. 2008

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The role of sub-cortical structures such as the striatum in language remains a controversial issue. Based on linguistic claims that language processing implies both recovery of lexical information and application of combinatorial rules it has been shown that striatal damaged patients have difficulties applying conjugation rules while lexical recovery of irregular forms is broadly spared (e.g., Ullman, M. T., Corkin, S., Coppola, M., Hickok, G., Growdon, J. H., Koroshetz, W. J., et al. (1997). A neural dissociation within language: Evidence that the mental dictionary is part of declarative memory, and that grammatical rules are processed by the procedural system. Journal of Cognitive Neuroscience, 9(2), 266-276). Here we bolstered the striatum-rule hypothesis by investigating lexical abilities and rule application at the phrasal level.Both processing aspects were assessed in a model of striatal dysfunction, namely Huntington's disease (HD). Using a semantic priming task we compared idiomatic prime sentences involving lexical access to whole phrases (e.g., "Paul has kicked the bucket") with idiom-derived sentences that contained passivation changes involving syntactic movement rules (e.g., "Paul was kicked by the bucket"), word changes (e.g., "Paul has crushed the bucket") or either. Target words that were either idiom-related (e.g., "death") reflecting lexical access to idiom meanings, word-related (e.g., "bail") reflecting lexical access to single words, or unrelated (e.g., "table").HD patients displayed selective abnormalities with passivated sentences whereas priming was normal with idioms and sentences containing only word changes. We argue that the role of the striatum in sentence processing specifically pertains to the application of syntactic movement rules whereas it is not involved in canonical rules required for active structures or in lexical processing aspects. Our findings support the striatum-rule hypothesis but suggest that it should be refined by tracking the particular kind of language rules depending on striatal computations.

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Section: Introductionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The role of the striatum in sentence processing: Evidence from a priming study in early stages of Huntington's disease

et al. 2008

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“…A unified interpretation of PD's language behavior in the present on-line electrophysiological comprehension study and in a number of off-line syntactic tasks in comprehension (Grossman et al, 1993;Natsopoulos et al, 1993) and during production (Ullman, Corkin, et al, 1997) may lie in the distinction between early automatic structure-building syntactic processes and more conscious syntactic processes, such as the generation of different verb forms (Ullman, Corkin, et al, 1997), sentence-judgment and question-answering tasks (Grossman et al, 1991(Grossman et al, , 1993, and the comprehension of sentences demanding syntactic working memory resources (Natsopoulos et al, 1993). Let us consider this interpretation in the light of studies investigating language and other cognitive functions in PD patients.…”

Section: Syntactic Processesmentioning

confidence: 97%

Syntactic comprehension in Parkinson's disease: Investigating early automatic and late integrational processes using event-related brain potentials.

et al. 2003

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Parkinson's disease (PD) has been associated with a general impairment of procedures and with an impairment of syntactic procedures in particular. The present study investigated comprehension processes in PD using event-related brain potentials (ERPs). PD patients and controls listened to sentences that were either correct or syntactically or semantically incorrect. The language-related ERP component correlated with semantic processes (N400) was present in both groups. In the syntactic domain, early automatic processes (early negativity) appeared normal in PD, whereas late integrational processes (P600) were modulated by this disease. The present findings suggest that the basal ganglia primarily do not support early automatic syntactic processes during comprehension but rather support processes of syntactic integration.

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“…Three general cognitive processes have been implicated in syntactic comprehension of sentences: (1) regulation of attention, (2) working memory and (3) speed of information processing. Several authors investigated syntactic complexity (e.g., subject-object relative clauses) during sentence comprehension in basal ganglia patients (e.g., Grossman et al, 1991Grossman et al, , 1992Grossman et al, , 1993Lieberman et al, 1990Lieberman et al, , 1992Natsopoulos et al, 1993;Pickett et al, 1998). While Grossman et al (1993) initially argued that syntactic comprehension deficits result from attentional rather than syntactic deficits, Lieberman et al (1990; proposed that repeated errors on syntactically complex sentences cannot be attributed to an attention deficit, but to a working memory deficit.…”

Section: Introductionmentioning

confidence: 99%

Syntactic language processing: ERP lesion data on the role of the basal ganglia

Kotz

Frisch

Cramon

et al. 2003

J Int Neuropsychol Soc

127

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The role of the basal ganglia in syntactic language processing was investigated with event-related brain potentials in fourteen neurologically impaired patients. Seven of these patients had basal ganglia lesions while 7 other patients primarily had lesions of the left temporo-parietal region excluding the basal ganglia. All patients listened to sentences that were either correct or included a verb argument structure violation. In previous experiments this type of violation elicited a biphasic pattern of an N400-P600 complex in young healthy participants. While the N400 may result from incorrect semantic-thematic role assignment, the P600 reflects the fact that verb information does not license the syntactic structure at present. Results of the patient experiment revealed a double dissociation: patients with left temporo-parietal lesions only show a P600, whereas patients with lesions of the basal ganglia showed no P600, but a negativity with extended duration that resembled an N400. The latter pattern not only confirms previous reports that the basal ganglia modulate the P600 but extends these results by showing that the N400 as a late semantic-thematic integration process appears partially modulated by the basal ganglia.

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Algorithmic and heuristic strategies in comprehension of complement clauses by patients with Parkinson's disease

Cited by 52 publications

References 61 publications

The role of the striatum in sentence processing: Evidence from a priming study in early stages of Huntington's disease

The role of the striatum in sentence processing: Evidence from a priming study in early stages of Huntington's disease

Syntactic comprehension in Parkinson's disease: Investigating early automatic and late integrational processes using event-related brain potentials.

Syntactic language processing: ERP lesion data on the role of the basal ganglia

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