Alginic Acid Polymer-Hydroxyapatite Composites for Bone Tissue Engineering

Sikkema, Rebecca; Keohan, Blanca; Zhitomirsky, Igor

doi:10.3390/polym13183070

Cited by 25 publications

(26 citation statements)

References 139 publications

(215 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the different bioceramics, hydroxyapatite (HA) and calcium phosphates have been proposed as ideal components of materials for bone tissue applications [6,[10][11][12]. The use of hydroxyapatite in vivo applications is well known due to its close structure and chemical composition to that of natural bone [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

2022

View full text Add to dashboard Cite

Nanocomposite films of polysulfone (PSF)—hydroxyapatite (HA) were prepared with a commercial airbrush. Structural, thermal, and mechanical characterization allows obtaining new information to understand the role of the nanofiller–polymer matrix interphase in the final performance of these materials in relation to its possible applications in the restoration of bones. Fourier-transform infrared spectroscopy shows that there are hardly any structural changes in the polymer when adding HA particles. From thermal analysis (differential scanning calorimetry and thermogravimetry), it can be highlighted that the presence of HA does not significantly affect the glass transition temperature of the PSF but decelerates its thermal degradation. All this information points out that any change in the PSF performance because of the addition of HA particles cannot be due to specific interactions between the filler and the polymer. Results obtained from uniaxial tensile tests indicate that the addition of small amounts of HA particles (1% wt) leads to elastic moduli higher than the upper bound predicted by the rule of mixtures suggesting there must be a high contribution of the interphase. A simple model of the nanocomposite is proposed for which three contributions must be considered, particles, interphase and matrix, in such a way that interphases arising from different particles can interact by combining with each other thus leading to a decrease in its global contribution when the amount of particles is high enough. The mechanical behavior can be explained considering a balance between the contribution of the interphase and the number of particles. Finally, a particular mechanism is proposed to explain why in certain nanocomposites relatively high concentrations of nanoparticles may substantially increase the strain to failure.

show abstract

Section: Introductionmentioning

confidence: 99%

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

2022

View full text Add to dashboard Cite

show abstract

“…The addition of inorganic bioactive materials, such as hydroxyapatite and silica, to polymer films is widely used for the surface modification of biomedical implants [39,40]. These two materials have specific advantageous properties for orthopaedic applications.…”

Section: Resultsmentioning

confidence: 99%

A Versatile Strategy for the Fabrication of Poly(ethyl methacrylate) Composites

Baker

Zhitomirsky

2022

J. Compos. Sci.

Self Cite

View full text Add to dashboard Cite

Poly(ethyl methacrylate) (PEMA) is dissolved in ethanol, known to be a non-solvent for PEMA, due to the solubilizing ability of an added bile acid biosurfactant, lithocholic acid (LA). The ability to avoid traditional toxic and carcinogenic solvents is important for the fabrication of composites for biomedical applications. The formation of concentrated solutions of high molecular weight PEMA is a key factor for the film deposition using the dip coating method. PEMA films provide corrosion protection for stainless steel. Composite films are prepared, containing bioceramics, such as hydroxyapatite and silica, for biomedical applications. LA facilitates dispersion of hydroxyapatite and silica in suspensions for film deposition. Ibuprofen and tetracycline are used as model drugs for the fabrication of composite films. PEMA-nanocellulose films are successfully prepared using the dip coating method. The microstructure and composition of the films are investigated. The conceptually new approach developed in this investigation represents a versatile strategy for the fabrication of composites for biomedical and other applications, using natural biosurfactants as solubilizing and dispersing agents.

show abstract

“…Reaction ( 2) is critical for the deposition process, because it results in the discharge of CBX 2− and deposition of insoluble CBXH 2 . The deposition mechanism described in Reactions (1) and ( 2) is similar to that used for anodic deposition of other small organic molecules and macromolecules [24,25,33,34].…”

Section: Resultsmentioning

confidence: 99%

Carbenoxolone as a Multifunctional Vehicle for Electrodeposition of Materials

et al. 2021

Self Cite

View full text Add to dashboard Cite

This investigation describes for the first time the application of carbenoxolone for electrophoretic deposition (EPD) of different carbon materials, polytetrafluoroethylene (PTFE) and their composite films. Carbenoxolone is a versatile biosurfactant, which adsorbs on materials due to its amphiphilic structure and allows their charging and dispersion. Moreover, carbenoxolone exhibits film-forming properties, which are investigated in experiments on EPD of films using water and ethanol-water solvents. The new deposition process is monitored in situ and the deposition yield and film microstructure are analyzed at different conditions. The EPD mechanism of materials involves electrode reactions of the carbenoxolone surfactant. The data of potentiodynamic studies coupled with the results of impedance spectroscopy show that PTFE films can be applied to protect metals from corrosion. Electron microscopy, electrochemical techniques and modeling are used for analysis of the microstructure and porosity of films prepared at different conditions. Carbenoxolone is applied as a co-surfactant for the EPD of composites.

show abstract

Alginic Acid Polymer-Hydroxyapatite Composites for Bone Tissue Engineering

Cited by 25 publications

References 139 publications

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

A Versatile Strategy for the Fabrication of Poly(ethyl methacrylate) Composites

Carbenoxolone as a Multifunctional Vehicle for Electrodeposition of Materials

Contact Info

Product

Resources

About