Alginates in Pharmaceutical and Biomedical Application: A Critique

Dave, Vivek S; Tak, Kajal; Gupta, Chanchal; Verma, Kanika; Sharma, Swapnil

doi:10.1002/9781119487999.ch6

Cited by 2 publications

(2 citation statements)

References 98 publications

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“…Biopolymers, alginate, and plant–animal products are naturally biocompatible and therefore serve as non-toxic sources of components widely used in biomedical applications. Alginate is a dressing material for wound healing, encapsulation, and controlled release of biomolecules or drugs in the biological system ( Dave, 2019 ). Additionally, the phenolic components of Aloe vera significantly stimulate cell proliferation and migration of skin cells to enhance wound healing ( Teplicki et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Fabrication and evaluation of herbal beads to slow cell ageing

Dhasmana

Malik

Sharma³

et al. 2022

Front. Bioeng. Biotechnol.

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Several therapies and cosmetics are available commercially to prevent or delay cell ageing, which manifests as premature cell death and skin dullness. Use of herbal products such as Aloe vera, curcumin, vitamin C-enriched natural antioxidant, and anti-inflammatory biomolecules are potential ways to prevent or delay ageing. Eggshell membrane (ESM) is also a rich source of collagen; glycosaminoglycans (GAGs) also play an essential role in healing and preventing ageing. It is important to use an extended therapeutic process to prolong the effectiveness of these products, despite the fact that they all have significant anti-ageing properties and the ability to regenerate healthy cells. Encapsulated herbal components are therefore designed to overcome the challenge of ensuring continued treatment over time to prolong the effects of a bioactive component after in situ administration. To study their synergistic effects on a cellular level, alginate, Aloe vera, and orange peel extract were encapsulated in bio-polymeric foaming beads and modified with eggshell membrane protein (ESMP) at various concentrations (1 gm, 2 gm, and 5 gm): (A-Av-OP, A-Av-OP-ESMP1, ESMP2, and ESMP3). Analysis of the structural and functional properties of foaming beads showed interconnected 3D porous structure, a surface-functionalized group for entrapment of ESMP, and a significant reduction in pore size (51–35 m) and porosity (80%–60%). By performing DPPH assays, HRBC stabilization assays, and antibacterial tests, the beads were assessed as a natural anti-ageing product with sustained release of molecules effective against inflammatory response, oxidative stress, and microbial contamination. MTT assays were conducted using in vitro cell cultures to demonstrate cytocompatibility (in mouse 3T3 fibroblast cells) and cytotoxicity (in human carcinoma HeLa cells). Our study demonstrates that bio-polymeric ESMP beads up to 2 g (A-Av-OP-ESMP2) are practical and feasible natural remedies for suspending defective cell pathways, preventing cell ageing, and promoting healthy cell growth, resulting in a viable and practical natural remedy or therapeutic system.

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Section: Resultsmentioning

confidence: 99%

Fabrication and evaluation of herbal beads to slow cell ageing

Dhasmana

Malik

Sharma³

et al. 2022

Front. Bioeng. Biotechnol.

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show abstract

“…The biopolymers of plant–animal origin are biocompatible and non-toxic sources widely used for food and clinical applications. Gelatin and alginate are dressing materials for wound healing, encapsulation, and control of the biological system’s release of biomolecules or drugs [ 38 , 39 , 48 ]. Here, the MTT assay result showed that cells cultured on the bio-polymeric beads have good cell viability, proliferation, and growth with progression over time ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

A Bioengineered Quercetin-Loaded 3D Bio-Polymeric Graft for Tissue Regeneration and Repair

et al. 2022

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Phytochemicals extracted from plant sources have potential remedial effects to cure a broad range of acute to severe illnesses and ailments. Quercetin is a flavonoid isolated from different dietary sources such as vegetables and fruits, exhibiting strong anti-inflammatory, anti-oxidative and non-toxic effects on the biological system. However, the direct uptake or administration of quercetin results in loss of functionality, poor activity, and reduced shelf-life of the bioactive component. In this regard, to improve the uptake, potential, and efficiency of natural components with prolonged storage in the host’s body after administration, numerous polymer drug delivery systems have been created. In the current study, three-dimensional (3D) porous (porosity: 92%; pore size: 81 µm) bio-polymeric foaming gelatin–alginate (GA) beads were fabricated for the entrapment of quercetin as therapeutic drug molecules—gelatin–alginate–quercetin (GAQ). The GAQ beads showed a significant uptake of quercetin molecules resulting in a reduction of reduced porosity up to 64% and pore size 63 µm with a controlled release profile in the PBS medium, showing ~80% release within 24 h. Subsequently, the GAQ beads showed remarkable antioxidant effects, and 95% anti-inflammatory activities along with remarkable in vitro cell culture growth and the observed proliferation of seeded fibroblast cells. Thus, we can conclude that the consistent release of quercetin showed non-toxic effects on normal cell lines and the bioactive surface of the GAQ beads enhances cell adhesion, proliferation, and differentiation more effectively than control GA polymeric beads and tissue culture plates (TCP). In summary, these findings show that these GAQ beads act as a biocompatible 3D construct with enormous potential in medicinal administration and tissue regeneration for accelerated healing.

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Alginates in Pharmaceutical and Biomedical Application: A Critique

Cited by 2 publications

References 98 publications

Fabrication and evaluation of herbal beads to slow cell ageing

Fabrication and evaluation of herbal beads to slow cell ageing

A Bioengineered Quercetin-Loaded 3D Bio-Polymeric Graft for Tissue Regeneration and Repair

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