Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of applications

Berardi, Alberto; Bauhuber, Sonja; Sawafta, Obada; Warnke, Gernot

doi:10.1016/j.ijpharm.2021.120512

Cited by 14 publications

(12 citation statements)

References 31 publications

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“…The complete disintegration of the tablet never implies the complete dissolution of the drug from the tablet formulation [21,22]. The dissolution rate of the paracetamol in this study not only depended on the mode of addition of the co-processed material but also on the nature of the binder used in the formulation [23][24][25][26][27]. Thus the results obtained in the study, if co-related scientifically; suggested better disintegration and dissolution performances of the tablets when co-processed crospovidone was added intra-granularly and crospovidone extra-granularly.…”

Section: Investigation Of the Functionality Of The Co-processed Mater...mentioning

confidence: 64%

Development of Paracetamol Tablets by Using Novel Coprocessed Granulation Binder-Disintegrant

Hardikar¹,

Patil²

2022

Int J Pharm Phytopharmacol Res

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Established disintegrating agents possess the disintegrating ability only and they rarely assist in the compactibility of powder blend except for starch. Many of the reported binders are proven to retard the release rate of the active drug from the dosage forms. Therefore the present work was aimed at developing a coprocessed binder-disintegrant to overcome these functional drawbacks of the binders and disintegrating agents. The novel binder-disintegrant was prepared by co-processing crospovidone and the gel obtained from the husk of Plantago Ovata seeds. To confirm the functionality of the novel co-processed binder-disintegrant under investigation; paracetamol was selected as a model drug. The absence of chemical interaction between the co-processed materials and the formation of hydrogen bonding between them was confirmed by the analytical technique of ATR-FTIR. The functionality of the co-processed material as a granulation binder was confirmed by the Heckel treatment. The linear relationship between ln (1/1-D) and compression pressure applied on the paracetamol tablets, confirmed the functionality of co-processed material as a granulation binder. These tablets were prepared by adding the novel co-processed granulation binder-disintegrant intragranularly at 5%. The functionality of novel co-processed material as a disintegrating agent was confirmed by analyzing the results of disintegration and dissolution studies of the paracetamol tablets. Paracetamol tablets exhibited faster disintegration when crospovidone was added extra granularly; than when a novel co-processed binder disintegrant was added. Thus, the functionality of the novel binder disintegrant was investigated by assessing the performance of the formulation of immediate-release tablets of paracetamol.

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Section: Investigation Of the Functionality Of The Co-processed Mater...mentioning

confidence: 64%

Development of Paracetamol Tablets by Using Novel Coprocessed Granulation Binder-Disintegrant

Hardikar¹,

Patil²

2022

Int J Pharm Phytopharmacol Res

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“…Place each tablet in a basket and the basket is stirred continuously in the disintegration medium. [ 41 ] Observe the disintegration of the tablet until it breaks down into tiny particles that can escape the basket, leaving no residual tablet particles in the basket. Unsealed (WP) tablet group as control, each disintegration analysis was carried out in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Poly(lactic acid) based Pearl Layer Moistureproof Membrane for Flexible Laminated Packaging

Zhao

Wang

et al. 2023

Macromol. Rapid Commun.

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The development of bio-based polymer materials, such as polylactic acid (PLA) -based polymers, is an effective strategy to reduce dependence on petrochemical-based polymers. However, the preparation of bio-based polymers with high barrier properties is a major challenge. To overcome this challenge, a nacreous layer structure with a ' brick and mud ' pattern is mimicked to improve the overall performance of the material. In this paper, Poly ( L -lactic acid) (PLLA) and Polypropylene Glycol (PPG) was combined to prepare bio-based polyurethane (PU-PLLA), which is used as the slurry structure of nacreous layer. The bio-based biomimetic composite membrane (PU-PLLA/BN) is then obtained by adding boron nitride (BN, brick structure of pearl layer) to it. The water vapor permeability test results show that the permeability of PU-PLLA material can be reduced by more than 50% by 5 wt.% BN, which is because the addition of BN can increase the length and tortuosity of the gas molecular diffusion path in the composite. Therefore, this pearl-inspired PU-PLLA/BN film has excellent moisture resistance, which opens up a broad road for the practical application of PLLA in flexible laminated packaging.

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“…Its most important advantages are excellent biocompatibility and biodegradability, as well as cost-effectiveness. In the research related to pharmaceutical technology and drug delivery, alginate can be used as a thickener, gelling, stabilizing agent [ 95 , 96 ], as well as tablet disintegrant [ 97 ]. As the polymer reveals the ability to interact with cations, it is an excellent material for obtaining various types of micro- and nanoparticles.…”

Section: Gum-based Micro- and Nanoparticles In Drug Deliverymentioning

confidence: 99%

Natural Gums in Drug-Loaded Micro- and Nanogels

et al. 2023

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Gums are polysaccharide compounds obtained from natural sources, such as plants, algae and bacteria. Because of their excellent biocompatibility and biodegradability, as well as their ability to swell and their sensitivity to degradation by the colon microbiome, they are regarded as interesting potential drug carriers. In order to obtain properties differing from the original compounds, blends with other polymers and chemical modifications are usually applied. Gums and gum-derived compounds can be applied in the form of macroscopic hydrogels or can be formulated into particulate systems that can deliver the drugs via different administration routes. In this review, we present and summarize the most recent studies regarding micro- and nanoparticles obtained with the use of gums extensively investigated in pharmaceutical technology, their derivatives and blends with other polymers. This review focuses on the most important aspects of micro- and nanoparticulate systems formulation and their application as drug carriers, as well as the challenges related to these formulations.

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Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of applications

Cited by 14 publications

References 31 publications

Development of Paracetamol Tablets by Using Novel Coprocessed Granulation Binder-Disintegrant

Development of Paracetamol Tablets by Using Novel Coprocessed Granulation Binder-Disintegrant

Poly(lactic acid) based Pearl Layer Moistureproof Membrane for Flexible Laminated Packaging

Natural Gums in Drug-Loaded Micro- and Nanogels

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