Alginates as biomaterials in tissue engineering

Andersen, Therese; Strand, Berit Løkensgard; Formo, Kjetil; Alsberg, Eben; Christensen, Bjørn E.

doi:10.1039/9781849732765-00227

Cited by 157 publications

(127 citation statements)

References 138 publications

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“…Particularly, Alg is well known for its high affinity towards Ca 2þ ions. Ca 2þ ions bind consecutive guluronic residues (G-blocks) in a cooperative manner producing the cross-link of the Alg [36]. However, the cross-linking with Ca 2þ ions is not only due to the interaction with G-blocks but also to the interaction between both mannuronic and guluronic residues (MG-blocks) [74].…”

Section: Discussionmentioning

confidence: 99%

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cattalini

Hoppe

Pishbin

et al. 2015

J. R. Soc. Interface.

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This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu 2þ or Ca 2þ (AlgNbgCu, AlgNbgCa, respectively). Twodimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu 2þ and Ca 2þ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu 2þ or Ca 2þ were developed with potential applications for preparation of multifunctional scaffolds for BTE.

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Section: Discussionmentioning

confidence: 99%

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cattalini

Hoppe

Pishbin

et al. 2015

J. R. Soc. Interface.

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“…Alginates are hydrocolloids and water-soluble biopolymers, which have been applied for immobilization and proliferation of cells (Andersen et al, 2012). This study evaluated the capability of Lactobacillus acidophilus cells, immobilized on catheter surfaces with sodium alginate, to inhibit the formation of biofilms by Escherichia coli, Klebsiella, Staphylococcus aureus and Pseudomonas aeruginosa in vitro.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of biofilms on urinary catheters using immobilized Lactobacillus cells

Ezeonu¹,

Kanu²

2016

Afr. J. Microbiol. Res.

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Bacterial biofilms forming on indwelling urinary catheters continue to represent a public health problem because they are associated with urinary tract infections (UTIs). This study was undertaken to evaluate the ability of immobilized Lactobacillus acidophilus cells to inhibit biofilm formation on catheter surfaces. Urine bacteria and Lactobacillus species were isolated from urine and vaginal swabs (HVS), respectively. Immobilization of L. acidophilus on catheter samples was achieved using sodium alginate and the inhibition of urine bacteria by the immobilized Lactobacillus cells was evaluated by microscopy and viable cell count procedures following co-culture of the immobilized cells and urine bacteria. Results showed that pre-coating of catheter surfaces with L. acidophilus before exposure to urine bacteria significantly (p<0.05) reduced attachment of some urine bacteria to the catheter surfaces. Staphylococcus aureus, Klebsiella and Escherichia coli were significantly inhibited, while Pseudomonas aeruginosa was not inhibited. Furthermore, crude bacteriocin preparations from the Lactobacillus cells had antimicrobial activity against the urine bacteria. This study shows that precoating of catheter surfaces with L. acidophilus could be an effective strategy for controlling biofilm formation on urinary catheters.

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“…[15][16][17][18][19][20][21][22][23] First of all, pieces of algae leaves were rinsed and immersed in water until they were expanded and then immersed in a 0.3% HCl solution for one hour. For each extraction experiment, 50 g of algae pieces were rinsed with distilled water and soaked in 1 L of a 4% (w/w) Na 2 CO 3 solution under continuous stirring a least two hours.…”

Section: Methodsmentioning

confidence: 99%

“…For tissue engineering, alginates scaffolds should be biocompatible to facilitate the process of cell regeneration. 16,17 Biocompability of alginate scaffold including the biodegradability and pore size for growth of cells was necessary. 18 Biodegradability is an essential factor as scaffolds were absorbed by the surrounding tissues.…”

mentioning

confidence: 99%

A study of extraction and characterization of alginates obtained from brown macroalgae Sargassum duplicatum and Sargassum crassifolium from Indonesia

Indrani

Budianto

2013

Dent. J. (Majalah Kedokteran Gigi)

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Alginates as biomaterials in tissue engineering

Cited by 157 publications

References 138 publications

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Inhibition of biofilms on urinary catheters using immobilized Lactobacillus cells

A study of extraction and characterization of alginates obtained from brown macroalgae Sargassum duplicatum and Sargassum crassifolium from Indonesia

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