Alginate Nanoparticles: A Potential Drug Carrier in Tuberculosis Treatment

Patel, Rakesh P.; Patel, Geeta K.; Patel, Nikunjana A.; Singh, Sudarshan; Chittasupho, Chuda

doi:10.1007/978-3-031-14100-3_11

Cited by 5 publications

(7 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eine Opioidsubstitutionsbehandlung reduziert die Mortalität unter opioidabhängigen Menschen nach Haftentlassung deutlich [18,19]. Zusammenfassend führt die Substitutionstherapie bei opioidabhängigen Menschen in Haft zu einer Minimierung des Drogenkonsums, was mit weniger Störungen im Behandlungsprozess einhergeht, einer besseren psychosozialen Situation, einem verminderten Risiko für HIV, HCV und HBV Infektionen, einer höheren Wahrscheinlichkeit an einer Anschlusstherapie nach Haftentlassung teilzunehmen, einer besseren Legalprognose, einer geringeren Mortalität nach Haftentlassung und weniger entzugsbedingten Gewalttaten [20][21][22][23][24].…”

Section: Die Substitutionsbehandlung Als Lege Artis Behandlung Im Maß...unclassified

Chancen und Hürden einer medikamenten-gestützten Behandlung Opioidabhängiger im deutschen Maßregelvollzug (MRV) – ein erster Überblick

Szonnert,

Hirsch,

Michels

et al. 2023

Suchttherapie

View full text Add to dashboard Cite

ZusammenfassungEine Opioidabhängigkeit ist eine schwere chronisch-rezidivierende Erkrankung, die eine lebenslange Behandlung erfordern kann. Diese evidenz-basierte Behandlungsmethode wird nur in sehr geringem Umfang im Maßregelvollzug angewendet.Die vorliegende Studie befasst sich mit den Chancen und Barrieren einer Opioidsubstitutionstherapie im Maßregelvollzug. Durch Expert*inneninterviews mit verantwortlichen Mediziner*innen aus Maßregelvollzugkliniken aus zehn Bundesländern in Deutschland und einer anschließenden qualitativen Inhaltsanalyse nach Kuckartz werden Chancen und Barrieren einer Opioidsubstitutionstherapie dargestellt. Die Ergebnisse zeigen Implementierungsprobleme und Lösungsvorschläge in den drei Themengebieten (a) Institutionelle / Strukturelle Barrieren, (b) Einstellungen des Fachpersonals und (c) Patient*innenbezogene Barrieren. Zudem wird die Substitutionstherapie regional sehr unterschiedlich bewertet.

show abstract

Section: Die Substitutionsbehandlung Als Lege Artis Behandlung Im Maß...unclassified

Chancen und Hürden einer medikamenten-gestützten Behandlung Opioidabhängiger im deutschen Maßregelvollzug (MRV) – ein erster Überblick

Szonnert,

Hirsch,

Michels

et al. 2023

Suchttherapie

View full text Add to dashboard Cite

show abstract

“…Warfarin's anticoagulant effect is achieved through the inhibition of vitamin K-dependent clotting factors II, VII, IX, and X, which involves competitive blocking of vitamin K epoxide reductase complex 1, an enzyme essential for vitamin K activation [9]. By diminishing the levels of these clotting factors, warfarin effectively reduces clot formation and mitigates the risk of thromboembolic events [9].…”

Section: Introductionmentioning

confidence: 99%

“…Given its narrow therapeutic index, warfarin necessitates frequent monitoring and dose adjustments to maintain the delicate balance between adequate anticoagulation and the risk of bleeding or thrombotic complications. Monitoring is typically conducted by assessing prothrombin time (PT) and the international normalized ratio (INR), with diligent surveillance of any elevations in PT/INR levels to prevent adverse outcomes [9].…”

Section: Introductionmentioning

confidence: 99%

Warfarin and Antibiotics: Drug Interactions and Clinical Considerations

Vega,

Smith,

Matejowsky

et al. 2023

Life

View full text Add to dashboard Cite

Warfarin administration poses a notable challenge in clinical practice due to the increased susceptibility of patients to major bleeding, particularly when co-administered with other medications capable of modulating its metabolic pathways. Among these medications, antibiotics have been recognized as potential agents that can either induce or inhibit cytochrome P450-2C9, thereby impacting the effects of warfarin. A wealth of evidence from numerous studies consistently supports an elevated risk of serious bleeding in patients concurrently receiving antibiotics and warfarin therapy. This narrative review elucidates the intricate interactions between warfarin and various antibiotic classes. Notably, significant increases in the International Normalized Ratio (INR) were observed among warfarin-treated patients receiving penicillin derivatives, fluoroquinolones, TMP-SMX, and macrolides. Conversely, investigations have also demonstrated a reduction in INR levels in patients on warfarin when exposed to rifampin, a potent inducer of cytochrome P-450. Intriguingly, cephalosporin antibiotics and amoxicillin/clavulanate, despite not interfering with the cytochrome P450 system, exhibited a positive association with increased INR values. The findings of this narrative review underscore the importance of diligent monitoring in patients on warfarin requiring concomitant antibiotic therapy, as this surveillance strategy proves pivotal in mitigating the risk of major bleeding complications. Additionally, for patients necessitating cytochrome P450 inhibitors such as penicillin derivatives, fluoroquinolones, TMP-SMX, and macrolides, the consideration of dose reduction in warfarin therapy may confer substantial benefits in reducing the occurrence of major bleeding events. Similarly, patients who are co-administered rifampin alongside warfarin necessitate vigilant monitoring, with a potential need for escalating warfarin doses to counteract the risk of a hypercoagulable state.

show abstract

“…Warfarin, commercially sold under the name of Coumadin in the United States, is an anticoagulant drug frequently prescribed to treat blood clots, deep vein thrombosis, and strokes in patients presenting with atrial fibrillation or artificial heart valves [ 1 ] . Warfarin was first approved by the Food and Drug Administration (FDA) in the United States in 1954 for the treatment of blood clots and, as of 2019, is one of the most prescribed medications in the United States, with approximately 14 million prescriptions [ 2 ] . Formation of blood clots, termed thrombosis, may occur either in the arteries or veins and result in either partial or complete blockage depending on the size of the occlusion that is generated [ 3 ] .…”

Section: Introductionmentioning

confidence: 99%

“…Many of the precursor clotting factors synthesized by the liver require the addition of vitamin K as a cofactor in order to bind to phospholipids located on the surface vascular endothelium and conduct the initiation of the clotting cascade [ 5 ] . Firstly, the glutamic acid residues of the precursor clotting factors undergo a gamma-carboxylation event mediated by the enzymatic activity of gamma-glutamyl carboxylase [ 2 , 4 ] . Carboxylation of the glutamic acid residues is coupled to the simultaneous conversion of reduced vitamin K hydroquinone to vitamin K epoxide, a reaction that must occur in order for the residues to undergo the carboxylation event [ 2 , 5 ] .…”

Section: Introductionmentioning

confidence: 99%

The association between warfarin usage and international normalized ratio increase: systematic analysis of FDA Adverse Event Reporting System (FAERS)

Morris,

Todd,

Aponte

et al. 2023

J Cardiovasc Aging

View full text Add to dashboard Cite

Introduction: Elevated international normalized ratio (INR) has been commonly reported as an adverse drug event (ADE) for patients taking warfarin for anticoagulant therapy. Aim: The purpose of this study was to determine the association between increased INR and the usage of warfarin by using the pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS). Methods: The ADEs in patients who took warfarin (N = 77,010) were analyzed using FAERS data. Association rule mining was applied to identify warfarin-related ADEs that were most associated with elevated INR (n = 15,091) as well as possible drug-drug interactions (DDIs) associated with increased INR. Lift values were used to identify ADEs that were most commonly reported alongside elevated INR based on the correlation between both item sets. In addition, this study sought to determine if the increased INR risk was influenced by sex, age, temporal distribution, and geographic distribution and were reported as reporting odds ratios (RORs). Results: The top 5 ADEs most associated with increased INR in patients taking warfarin were decreased hemoglobin (lift = 2.31), drug interactions (lift = 1.88), hematuria (lift = 1.58), asthenia (lift = 1.44), and fall (lift = 1.32). INR risk increased as age increased, with individuals older than 80 having a 63% greater likelihood of elevated INR compared to those younger than 50. Males were 9% more likely to report increased INR as an ADE compared to females. Individuals taking warfarin concomitantly with at least one other drug were 43% more likely to report increased INR. The top 5 most frequently identified DDIs in patients taking warfarin and presenting with elevated INR were acetaminophen (lift = 1.81), ramipril (lift = 1.71), furosemide (lift = 1.64), bisoprolol (lift = 1.58), and simvastatin (lift = 1.58). Conclusion: The risk of elevated INR increased as patient age increased, particularly among those older than 80. Elevated INR frequently co-presented with decreased hemoglobin, drug interactions, hematuria, asthenia, and fall in patients taking warfarin. This effect may be less pronounced in women due to the procoagulatory effects of estrogen signaling. Multiple possible DDIs were identified, including acetaminophen, ramipril, and furosemide.

show abstract

Alginate Nanoparticles: A Potential Drug Carrier in Tuberculosis Treatment

Cited by 5 publications

References 128 publications

Chancen und Hürden einer medikamenten-gestützten Behandlung Opioidabhängiger im deutschen Maßregelvollzug (MRV) – ein erster Überblick

Chancen und Hürden einer medikamenten-gestützten Behandlung Opioidabhängiger im deutschen Maßregelvollzug (MRV) – ein erster Überblick

Warfarin and Antibiotics: Drug Interactions and Clinical Considerations

The association between warfarin usage and international normalized ratio increase: systematic analysis of FDA Adverse Event Reporting System (FAERS)

Contact Info

Product

Resources

About