Alginate: Microbial production, functionalization, and biomedical applications

Wang, Jianfei; Liu, Shijie; Huang, Jiaqi; Ren, Kexin; Zhu, Yan; Yang, Shiqi

doi:10.1016/j.ijbiomac.2023.125048

Cited by 22 publications

(8 citation statements)

References 163 publications

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“…Furthermore, the controlled release properties exhibited by these natural-source nanoparticles have been substantiated in controlled experiments, demonstrating their ability to modulate drug delivery kinetics. This controlled release feature proves pivotal in achieving a sustained and targeted delivery of therapeutic agents, substantiated by pharmacokinetic studies illustrating prolonged drug release profiles . Environmental sustainability is another dimension where scientific evidence supports the advantages of natural-source nanoparticles.…”

Section: Characteristic Features Of Nanoparticles As a Drug Carriermentioning

confidence: 99%

“…This controlled release feature proves pivotal in achieving a sustained and targeted delivery of therapeutic agents, substantiated by pharmacokinetic studies illustrating prolonged drug release profiles. 97 Environmental sustainability is another dimension where scientific evidence supports the advantages of natural-source nanoparticles. Comparative life cycle assessments reveal a reduced environmental impact associated with their production and utilization.…”

Section: Characteristic Features Of Nanoparticles As a Drug Carriermentioning

confidence: 99%

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Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

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Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important in reproductive health care, which has become an emerging and significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, and reproductive cancers. Nanotechnology presents promising solutions to address these concerns by introducing innovative tools and techniques, facilitating early detection, targeted drug delivery, and improved imaging capabilities. Through the utilization of nanoscale materials and devices, researchers can craft treatments that are not only more precise but also more effective, significantly enhancing outcomes in reproductive healthcare. Looking forward, the future of nanotechnology in reproductive medicine holds immense potential for reshaping diagnostics, personalized therapies, and fertility preservation. The utilization of nanotechnology-driven drug delivery systems is anticipated to elevate treatment effectiveness, minimize side effects, and offer patients therapies that are not only more precise but also more efficient. This review aims to delve into the various types, properties, and preparation techniques of nanocarriers specifically designed for drug delivery in the context of reproductive disorders, shedding light on the current landscape and potential future directions in this dynamic field.

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Section: Characteristic Features Of Nanoparticles As a Drug Carriermentioning

confidence: 99%

Section: Characteristic Features Of Nanoparticles As a Drug Carriermentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

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“…For example, it enables the precise targeting and elimination of the 1-4 glycosidic bond within alginate molecules, resulting in clear product structures with exceptional purity that facilitate subsequent separation and purification procedures. In contrast, the microorganism approach involves intricate biological pathways that can introduce variability, potentially compromising product quality and purity [20].…”

Section: Introductionmentioning

confidence: 99%

Expression and Characterization of an Efficient Alginate Lyase from Psychromonas sp. SP041 through Metagenomics Analysis of Rotten Kelp

Wang,

Cai,

Zhong

et al. 2024

Genes

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Alginate is derived from brown algae, which can be cultivated in large quantities. It can be broken down by alginate lyase into alginate oligosaccharides (AOSs), which exhibit a higher added value and better bioactivity than alginate. In this study, metagenomic technology was used to screen for genes that code for high-efficiency alginate lyases. The candidate alginate lyase gene alg169 was detected from Psychromonas sp. SP041, the most abundant species among alginate lyase bacteria on selected rotten kelps. The alginate lyase Alg169 was heterologously expressed in Escherichia coli BL21 (DE3), Ni-IDA-purified, and characterized. The optimum temperature and pH of Alg169 were 25 °C and 7.0, respectively. Metal ions including Mn2+, Co2+, Ca2+, Mg2+, Ni2+, and Ba2+ led to significantly increased enzyme activity. Alg169 exhibited a pronounced dependence on Na+, and upon treatment with Mn2+, its activity surged by 687.57%, resulting in the highest observed enzyme activity of 117,081 U/mg. Bioinformatic analysis predicted that Alg169 would be a double-domain lyase with a molecular weight of 65.58 kDa. It is a bifunctional enzyme with substrate specificity to polyguluronic acid (polyG) and polymannuronic acid (polyM). These results suggest that Alg169 is a promising candidate for the efficient manufacturing of AOSs from brown seaweed.

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“…Gel fibers can also be used to mimic the extracellular matrix to enhance the proliferation of epithelial cells, and the fibrous network can promote hemostasis in injured tissues, enhance fluid absorption and promote drug delivery, cellular respiration and gas permeation in the skin [ 14 , 15 , 16 ]. However, dressings made from pure alginate hydrogel fibers are incapable to produce therapeutic effects such as preventing bacterial infection and promoting tissue regeneration, especially in chronic wound healing situations [ 8 , 17 ]. Loading with therapeutic factors or other modifiers can improve cell adhesion, antimicrobial activity, blood coagulation and hemostasis in gel dressings [ 8 , 18 ], thus the development of alginate hydrogel fibers loaded with active or therapeutic components is of practical research interest.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Preparation of pH-Responsive Microsphere Fibers and Their Controlled Drug Release Properties

Wang,

Wei,

et al. 2023

Molecules

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In this study, a capillary microfluidic device was constructed, and sodium alginate solution and a pH-sensitive hydrophobic polymer (p(BMA-co-DAMA-co-MMA)) solution were introduced into the device for the preparation of hydrogel fibers loaded with polymer microspheres. The structure of the microsphere fiber, including the size and spacing of the microspheres, could be controlled by flow rate, and the microspheres were able to degrade and release cargo responding to acidic pH conditions. By modification with carboxymethylcellulose (CMC), alginate hydrogel exhibited enhanced pH sensitivity (shrunk in acidic while swollen in basic condition). This led to an impact on the diffusion rate of the molecules released from the inner microspheres. The microsphere fiber showed dramatic and negligible degradation and drug release in tumor cell (i.e., A431 and A549 cells) and normal cell environments, respectively. These results indicated that the microsphere fiber prepared in this study showed selective drug release in acidic environments, such as tumor and inflammation sites, which could be applied as a smart surgical dressing with normal tissue protective properties.

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Alginate: Microbial production, functionalization, and biomedical applications

Cited by 22 publications

References 163 publications

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Expression and Characterization of an Efficient Alginate Lyase from Psychromonas sp. SP041 through Metagenomics Analysis of Rotten Kelp

Microfluidic Preparation of pH-Responsive Microsphere Fibers and Their Controlled Drug Release Properties

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