Alginate mediated functional aggregation of gold nanoclusters for systemic photothermal therapy and efficient renal clearance

Zhao, Pengwei; Liu, Shuwei; Wang, Lu; Liu, Guojian; Cheng, Yanru; Lin, Min; Sui, Kunyan; Zhang, Hao

doi:10.1016/j.carbpol.2020.116344

Cited by 32 publications

(18 citation statements)

References 57 publications

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“…[44] Moreover, Zhao et al synthesized gold NCs by using sodium alginate as both the stabilizer and the reducing agent. [45] Sahoo et al developed a convenient and "green" method to synthesize gold NCs by using chitosan and mercaptopropionic acid as the reducing agents and the stabilizers. [46] Carboxymethyl cellulose (CMC), one of the most promising cellulose derivatives, shows a wide range of applications in food packaging materials, wound dressing, and hydrogels for functional biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Silver Nanoclusters and Nanocomposite Films Based on Coordinated Electrodeposition of Carboxymethyl Cellulose

Wang

et al. 2022

Macro Materials & Eng

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Here, a facile and green approach based on the coordinated electrodeposition of carboxymethyl cellulose (CMC) is developed to fabricate silver nanoclusters (AgNCs) and AgNCs/CMC nanocomposite films. In the approach, CMC not only serves as the electrodeposition polysaccharide, but also acts as the stabilizing agent and reducing agent for the synthesis of AgNCs, as well as the major component in the resulting AgNCs/CMC nanocomposite film. After the electrodeposition and incubation, a homogeneous and smooth film is generated on the anodic electrode, which exhibits a clear yellow florescence. Transmission electron microscopy observation shows that there are nanoparticles with the average size of 1.7 nm in the nanocomposite film. X‐ray photoelectron spectroscopy, UV–vis absorption spectroscopy, and fluorescence spectroscopy both confirm that there are AgNCs in the nanocomposite film. The AgNCs/CMC nanocomposite film shows the capability for fluorescence detection by using the fluorescence quenching features of AgNCs. Moreover, the AgNCs/CMC‐modified electrode can be conveniently and directly produced, which presents potential applications for electrochemical biosensors. Thus, this study provides a novel approach for the green synthesis of AgNCs and direct fabrication of the AgNCs/CMC nanocomposite film, which can be promisingly applied for constructing functional nanocomposites and advanced biodevices.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Silver Nanoclusters and Nanocomposite Films Based on Coordinated Electrodeposition of Carboxymethyl Cellulose

Wang

et al. 2022

Macro Materials & Eng

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“…However, they are relatively difficult to synthesize, can be contaminated with toxic surfactants used in their preparation (e.g., cetyltrimethylammonium bromide, CTAB) and are also relatively large in size (~over 50 nm), which can promote an efficient capture by the reticuloendothelial system (RES), limiting systemic circulation time, tumor targeting, efficient endocytosis into cancerous cells and posing potential clearance problems when clinically tried [ 11 , 17 , 18 ]. Recent reports suggest that these disadvantages of PTT with complex anisotropic gold nanostructures can be overcome through an employment of the gold NPs with aggregation triggered by tumor-specific stimuli (e.g., pH), thus inducing NIR absorbance in situ in the targeted area (i.e., malignant tissue) and providing significant improvement of PTT of cancer [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Magneto-Plasmonic Fe3O4/Au Nanocomposites: Approaching Magnetophoretically-Enhanced Photothermal Therapy

et al. 2021

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Magneto-plasmonic nanocomposites can possess properties inherent to both individual components (iron oxide and gold nanoparticles) and are reported to demonstrate high potential in targeted drug delivery and therapy. Herein, we report on Fe3O4/Au magneto-plasmonic nanocomposites (MPNC) synthesized with the use of amino acid tryptophan via chemical and photochemical reduction of Au ions in the presence of nanosized magnetite. The magnetic field (MF) induced aggregation was accompanied by an increase in the absorption in the near-infrared (NIR) spectral region, which was demonstrated to provide an enhanced photothermal (PT) effect under NIR laser irradiation (at 808 nm). A possibility for therapeutic application of the MPNC was illustrated using cancer cells in vitro. Cultured HeLa cells were treated by MPNC in the presence of MF and without it, following laser irradiation and imaging using confocal laser scanning microscopy. After scanning laser irradiation of the MPNC/MF treated cells, a formation and rise of photothermally-induced microbubbles on the cell surfaces was observed, leading to a damage of the cell membrane and cell destruction. We conclude that the synthesized magneto-plasmonic Fe3O4/Au nanosystems exhibit magnetic field-induced reversible aggregation accompanied by an increase in NIR absorption, allowing for an opportunity to magnetophoretically control and locally enhance a NIR light-induced thermal effect, which holds high promise for the application in photothermal therapy.

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“…These nanomaterials can present different structural organizations (e.g., spheres, rods, cages, shells and clusters) and sizes, which can be optimized to present a strong NIR absorption and high photothermal capacity by fine-tuning the localized surface plasmon resonance (LSPR) phenomenon [ 7 , 12 , 16 , 17 ]. The gold nanoclusters result from the gold nanospheres’ aggregation, linkage or formation in close proximity and have been explored to increase the applicability of gold nanospheres in cancer therapy [ 7 , 18 , 19 ]. Some of the most common strategies are based on the entrapment of gold nanospheres in large templates such as Albumin and PLGA-based nanoparticles or even the utilization of crosslinking spacer-arms [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of the GSH-Mediated Formation of Mesoporous Silica-Coated Gold Nanoclusters for NIR Light-Triggered Photothermal Applications

et al. 2021

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Cancer light-triggered hyperthermia mediated by nanomaterials aims to eliminate cancer cells by inducing localized temperature increases to values superior to 42 °C, upon irradiation with a laser. Among the different nanomaterials with photothermal capacity, the gold-based nanoparticles have been widely studied due to their structural plasticity and advantageous physicochemical properties. Herein, a novel and straightforward methodology was developed to produce gold nanoclusters coated with mesoporous silica (AuMSS), using glutathione (GSH) to mediate the formation of the gold clusters. The obtained results revealed that GSH is capable of triggering and control the aggregation of gold nanospheres, which enhanced the absorption of radiation in the NIR region of the spectra. Moreover, the produced AuMSS nanoclusters mediated a maximum temperature increase of 20 °C and were able to encapsulate a drug model (acridine orange). In addition, these AuMSS nanoclusters were also biocompatible with both healthy (fibroblasts) and carcinogenic (cervical cancer) cells, at a maximum tested concentration of 200 μg/mL. Nevertheless, the AuMSS nanoclusters’ NIR light-triggered heat generation successfully reduced the viability of cervical cancer cells by about 80%. This confirms the potential of the AuMSS nanoclusters to be applied in cancer therapy, namely as theragnostic agents.

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Alginate mediated functional aggregation of gold nanoclusters for systemic photothermal therapy and efficient renal clearance

Cited by 32 publications

References 57 publications

Fabrication of Silver Nanoclusters and Nanocomposite Films Based on Coordinated Electrodeposition of Carboxymethyl Cellulose

Fabrication of Silver Nanoclusters and Nanocomposite Films Based on Coordinated Electrodeposition of Carboxymethyl Cellulose

Multifunctional Magneto-Plasmonic Fe3O4/Au Nanocomposites: Approaching Magnetophoretically-Enhanced Photothermal Therapy

Optimization of the GSH-Mediated Formation of Mesoporous Silica-Coated Gold Nanoclusters for NIR Light-Triggered Photothermal Applications

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