Alginate Hydrogels Coated with Chitosan for Wound Dressing

Straccia, Maria Cristina; d’Ayala, Giovanna Gomez; Romano, Ida; Oliva, Adriana; Laurienzo, Paola

doi:10.3390/md13052890

Cited by 135 publications

(88 citation statements)

References 42 publications

(45 reference statements)

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“…274 As for the polymers composed mainly of CS, semi-interpenetrating CMCh/poly(acrylonitrile) hydrogels were reported to have clearly better antibacterial activity with more CMCh, and hydrogel coating by electrophoretic co-deposition of CS/alkynyl CS exhibited better antibacterial activities than pure CS hydrogel. 19,275 In the study by Straccia et al, 276 alginate hydrogels coated with CS hydrochloride showed intrinsic antimicrobial activity against E. coli. Quaternary ammonium CS/PVA/polyethylene oxide (PEO) hydrogels were reported to exhibit a pronounced inhibitory effect against S. aureus and E. coli.…”

Section: Antimicrobial Polysaccharidesmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

290

223

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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Section: Antimicrobial Polysaccharidesmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

290

223

View full text Add to dashboard Cite

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“…In addition, alginates or chitosan as two natural biopolymers were used to perform natural dressings with haemostatic properties . Furthermore, the combination of biologically effective polysaccharides such as chitosan and alginic acid or carrageenan to form hydrogels applied to dressings has shown an interesting biological effect …”

Section: Introductionmentioning

confidence: 99%

Synthesis and study of a new biopolymer‐based chitosan/hematoxylin grafted to cotton wound dressings

Alminderej

El‐Ghoul

2019

J of Applied Polymer Sci

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The present paper describes the development of wound dressing with high-enhanced biological characteristics. Firstly, we have synthesized a new polymer-based chitosan/hematoxylin (poly-PAA-CZ-HX), a bioactive blend for combined antibacterial and tissue regeneration properties. The main aim was to functionalize the wound dressing biomaterial with this bioactive medical polymer via a chemical grafting process. This functionalization must offer a permanent graft and preserve the medical properties of the added polymer of chitosan/hematoxylin. We have then studied the influence of different parameters involved in this particular grafting processing. Main parameters included thermofixation conditions (time and temperature) in addition to the concentration of different reactants. The last mentioned consist of a crosslinking agent the polyacrylic acid (PAA), a selected catalyst the sodium dihydrogen hypophosphite (NaH 2 PO 2 ), and thepoly-PAA-CZ-HX. Sorption capacity of modified dressings was then evaluated via the technique of the contact angle at various grafting rates. These wettability measurements have revealed a significant decrease of the contact angle of samples after functionalization, a desired characteristic of wound dressings, which means the clear improvement of the hydrophilicity. After the untreated and grafted cotton dressings were characterized by ATR-IR spectroscopy and TGA/DTA analysis, the results showed a chemical permanent grafting that resisted to standardized washings. Then an evaluation of mechanical properties of cotton dressings grafted with various proportions of poly-PAA-CZ-HX polymer was accomplished. Results revealed that the grafting reaction with selected conditions did not damage the mechanical characteristics of our native wound dressings. Finally, a SEM morphological study confirmed the permanent graft of the crosslinked CZ/HX biopolymer grafted to the cotton fibers and allowed us to evaluate its chemical grafting mode onto functionalized surfaces.

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“…4 Alginate possesses excellent biocompatibility, low toxicity and its derivatives (i.e., hydrogel, beads, scaffolds, and fibers) are widely used in biological materials, such as delivery system for drug, protein, or cells, wound dressings, blood vessels, tissue engineering scaffolds, and other biomaterials. [5][6][7][8][9][10][11][12][13][14] The calcium alginate fibers (CAFs) are fabricated by wet spinning process. In the process, CA nascent filaments are prepared by extruding sodium alginate (SA) solution into the coagulation solution containing a large amount of Ca 21 ions.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the degradation behavior of calcium alginate fibers wound dressings fabricated by needle‐punching process

Gao

Jin

2018

J of Applied Polymer Sci

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Calcium alginate fibers (CAFs) needle‐punched nonwovens are natural polysaccharide biological dressings. Wound exudates cause salt degradation of CA macromolecules. Herein, degradation process, degradation mechanism, and performance variations of degraded dressings were investigated. The functional group structures changed slightly, while the aggregation structure degraded remarkably. CAF turned into composite containing fiber and sodium alginate (SA) gels, finally degraded to SA gels. The initial degraded dressings maintained stable three‐dimensional (3D) interconnected porous structure. As the degradation and re‐entanglement of CAFs, the dressings changed from volatile composite constituted by degraded CAFs and SA gels to steady foam‐like structure bonded by SA gels with independent pores. Degradation caused significant changes in the interaction between CAFs, altering the stretching and compressing processes of the dressings. SA gels and CAFs formed a stable 3D structure with certain mechanical properties. The bonded SA gels improved the absorption, diffusion, and storage of the wound exudates in the degraded dressings. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46670.

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Alginate Hydrogels Coated with Chitosan for Wound Dressing

Cited by 135 publications

References 42 publications

Antimicrobial hydrogels: promising materials for medical application

Antimicrobial hydrogels: promising materials for medical application

Synthesis and study of a new biopolymer‐based chitosan/hematoxylin grafted to cotton wound dressings

Characterizing the degradation behavior of calcium alginate fibers wound dressings fabricated by needle‐punching process

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