Alginate gelation in microfluidic channels

Amici, E.; Tetradis-Meris, Georgios; Torres, C. Pulido de; Jousse, Fabien

doi:10.1016/j.foodhyd.2007.01.022

Cited by 58 publications

(33 citation statements)

References 27 publications

(32 reference statements)

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“…However, the formation of tail-shaped or tadpole-shaped Ca-ALG microgels is unavoidable due to the gravitational force and interfacial effect when they drip into the collection bath [24][25][26]. We note that internal gelation takes place in the microchannel and is nearly simultaneous with the formation of Na-ALG droplets [27][28][29][30][31][32]. In this method, to supply of Ca 2+ for crosslinking of Na-ALG droplets, CaCO 3 powder [27] or CaCO 3 nanoparticles (NPs) [29,30] are usually suspended in the Na-ALG solution or oil phase, combined with another acidic aqueous or oil phase.…”

Section: Introductionmentioning

confidence: 80%

“…For the preparation of Ca-ALG microgels with this technique, the crosslinking of sodium alginate (denoted as Na-ALG) droplets usually use either external gelation [23][24][25][26] or internal gelation [27][28][29][30][31]. In the case of external gelation, the Na-ALG droplets produced in microchannel drip down into a collection bath containing an aqueous CaCl 2 solution and followed by a crosslinking reaction of Ca 2+ and carboxyl groups of alginate [23].…”

Section: Introductionmentioning

confidence: 99%

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Alginate droplets pre-crosslinked in microchannels to prepare monodispersed spherical microgels

Wang

Liu

Wang

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Alginate droplets pre-crosslinked in microchannels to prepare monodispersed spherical microgels

Wang

Liu

Wang

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Sieving can be utilized to obtain microgels of specific size with a relatively monodisperse size distribution [21]. Alternative homogenization techniques to produce microgels with more precise control over their size and monodispersity include membrane emulsification [81] and microfluidics [55,82]; microfluidics also offers the potential for greater control over composition and facilitates the incorporation of active ingredients. Alternatively, spherical biopolymer microgel particles can be produced using a technique that involves spray drying a biopolymer solution and then controlling the rehydration process in a gelling medium [83].…”

Section: Biopolymer Microgels and Particle Anisotropymentioning

confidence: 99%

Rheology of Industrially Relevant Microgels

Stokes

2011

Microgel Suspensions

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Microgels are currently used in a broad range of industrial applications and consumer products, including surface coatings, paints, inks, oil recovery, controlled drug delivery, cosmetics, personal care, home care, food, and pharmaceuticals. An essential feature in many of these applications is the rheology of the microgel suspension during processing, storage, and transport, as well as during the application process itself (i.e., at the in-use or end-use stage). Microgel suspensions have a long history of use for rheological control due to their ability to swell in a suitable solvent to give increased viscosity and/or a gel-like consistency. Starches, which are essentially cross-linked carbohydrate polymers, are probably the oldest example of a microgel; they were separated from grains by the ancient Greeks for a variety of uses including foods, adhesives, and even wound healing, where the latter was achieved by mixing with saliva to form a honey-like coating [1].The attraction of microgel suspensions in industrial applications is that their rheology can be controlled to meet the requirements for specific applications by varying composition, cross-link density, particle size, shape, surface properties, and solvent quality. A useful feature of microgels is their responsive nature to their environment; they can swell or deswell by altering solvent quality (through pH, temperature, ions, etc.), thus altering their effective phase volume and consequently the rheological properties of the suspension. The deformable and swellable nature of microgels allows a higher phase volume to be obtained compared to hard spheres of equivalent size. Their deformability also affects their response in shear flow due to their ability to change shape in response to perturbation, particularly at high volume fractions. The composition of microgels can be adapted and customized according to the application, and the microgel additives used have been made out of a wide variety of polymeric materials including natural or modified biopolymer-based components (e.g., polysaccharides, proteins, and starches), and synthesized components such as polyacrylates, poly(styrene sulfonates), poly(vinyl pyridine), and polyurethanes. Microgel Suspensions: Fundamentals and ApplicationsEdited

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“…Durch Eindiffundieren von Essigsäure aus der Ölphase in die emulgierten Tröpfchen werden die Kationen dann aus den Carbonaten freigesetzt. [223,224] Alginat-Geltröpfchen eignen sich beispielsweise zum Einkapseln von Zellen. [225,226] Shen und Mitarbeiter erzeugten vor kurzem andere Hydrogelpartikel, wobei sie die Selbstorganisation von Hydrogelbildnern in Wassertröpfchen beim langsamen Abkühlen im Fluss von 70 8C am Ort der Tröpfchenbildung auf unter 64 8C nutzten.…”

Section: Gelbildung In Tröpfchenunclassified

Mikrotröpfchen in Mikrofluidiksystemen: eine Technik für Entdeckungen in der Chemie und Biologie

et al. 2010

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Mikrotröpfchen in Mikrofluidiksystemen bieten zahlreiche Möglichkeiten für die chemische und biologische Forschung. Sie ermöglichen die isolierte Betrachtung von Spezies oder Reaktionen, sie sind monodispers und daher für quantitative Studien geeignet, sie können für Studien in extrem kleinen Volumina sowie an einzelnen Zellen oder einzelnen Molekülen eingesetzt werden, und sie sind für Hochdurchsatzexperimente geeignet. Dieser Aufsatz analysiert die Bedeutung dieser Eigenschaften im Hinblick auf neue biologische und chemische Experimente, wobei jüngste Fortschritte bei der Entwicklung von Apparaturen vorgestellt, aber auch verbleibende technologische Herausforderungen angesprochen werden. Anhand von Beispielen wird gezeigt, welche Vorteile die Kompartimentierung, die Monodispersität der Tröpfchen, die Betrachtung einzelner Moleküle und der hohe Durchsatz in Experimenten gebracht haben, die ohne den Einsatz von Mikrofluidiksystemen kaum möglich gewesen wären.

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Alginate gelation in microfluidic channels

Cited by 58 publications

References 27 publications

Alginate droplets pre-crosslinked in microchannels to prepare monodispersed spherical microgels

Alginate droplets pre-crosslinked in microchannels to prepare monodispersed spherical microgels

Rheology of Industrially Relevant Microgels

Mikrotröpfchen in Mikrofluidiksystemen: eine Technik für Entdeckungen in der Chemie und Biologie

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