Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile

Петрова, В. А.; Elokhovskiy, Vladimir; Raik, Sergei V.; Poshina, Daria N.; Романов, Д. А.; Skorik, Yury А.

doi:10.3390/biom9070291

Cited by 45 publications

(37 citation statements)

References 32 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hybrid nanocomposites are an important platform for the preparation of new materials with advanced properties [1][2][3][4][5][6][7][8]. Noble metal nanostructures encapsulated within or deposited on biopolymers are of particular interest for human [9,10], sensing [11,12], and catalytic applications [13][14][15][16], as these types of materials combine the physicochemical features of noble metal nanostructures and the biological features of polymers [17,18].…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Zienkiewicz-Strzałka

Deryło–Marczewska

Skorik

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

A simple, low-cost, and reproducible method for creating materials with even silver nanoparticles (AgNP) dispersion was established. Chitosan nanofibers with silica phase (CS/silica) were synthesized by an electrospinning technique to obtain highly porous 3D nanofiber scaffolds. Silver nanoparticles in the form of a well-dispersed metallic phase were synthesized in an external preparation step and embedded in the CS/silica nanofibers by deposition for obtaining chitosan nanofibers with silica phase decorated by silver nanoparticles (Ag/CS/silica). The antibacterial activity of investigated materials was tested using Gram-positive and Gram-negative bacteria. The results were compared with the properties of the nanocomposite without silver nanoparticles and a colloidal solution of AgNP. The minimum inhibitory concentration (MIC) of obtained AgNP against Staphylococcus aureus (S. aureus) ATCC25923 and Escherichia coli (E. coli) ATCC25922 was determined. The physicochemical characterization of Ag/CS/silica nanofibers using various analytical techniques, as well as the applicability of these techniques in the characterization of this type of nanocomposite, is presented. The resulting Ag/CS/silica nanocomposites (Ag/CS/silica nanofibers) were characterized by small angle X-ray scattering (SAXS), X-ray diffraction (XRD), and atomic force microscopy (AFM). The morphology of the AgNP in solution, both initial and extracted from composite, the properties of composites, the size, and crystallinity of the nanoparticles, and the characteristics of the chitosan fibers were determined by electron microscopy (SEM and TEM).

show abstract

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Zienkiewicz-Strzałka

Deryło–Marczewska

Skorik

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Subsequent heating of the nonwoven CS led to a solubility loss and a reduction in the degree of swelling in water and in physiological saline ( Table 2 ); these changes were associated with the formation of amide crosslinks [ 44 ]. The nonwoven ALG&CNW was partially dissolved in water and contained microgels ( Table 2 ) composed of the PEC that formed as a result of the interaction between the CNW amino groups and the ALG carboxyl groups [ 25 ]. Heating of the nonwoven CS-ALG&CNW ( Table 2 ) led to a loss of solubility in water and physiological saline due to strengthening of the chemical interactions.…”

Section: Resultsmentioning

confidence: 99%

“…The chitosan used in this study was from crab shells (Qingdao Honghai Bio-tech Co., Ltd., Qingdao, Shandong, China) and had a viscosity average molecular weight M η of 1.1 × 10 5 and a deacetylation degree of 0.98 [ 13 ]. Sodium alginate with M η of 1.3 × 10 5 [ 25 ] was purchased from Qingdao Bright Moon Seaweed Group Co. Ltd. (Qingdao, Shandong, China). CNW were prepared by partial deacetylation of chitin [ 35 ] and had a degree of deacetylation of 0.40 [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

“…The high surface area of CNW facilitates their effective interaction with cells, proteins, and other compounds and makes CNW useful in wound dressings [ 22 , 23 , 24 ]. We have also demonstrated that reinforcement of polymeric composites (films, gels, fibers) with CNW can alter the morphology, structure, and porosity of composites [ 25 ] to improve cell adhesion and proliferation [ 26 ]. The chemical, morphological, and mechanical properties of CNW make them attractive in tissue engineering as they impart biological and mechanical properties that mimic the native ECM that regulates cell behavior [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytocompatibility of Bilayer Scaffolds Electrospun from Chitosan/Alginate-Chitin Nanowhiskers

et al. 2020

Self Cite

View full text Add to dashboard Cite

In this work, a bilayer chitosan/sodium alginate scaffold was prepared via a needleless electrospinning technique. The layer of sodium alginate was electrospun over the layer of chitosan. The introduction of partially deacetylated chitin nanowhiskers (CNW) stabilized the electrospinning and increased the spinnability of the sodium alginate solution. A CNW concentration of 7.5% provided optimal solution viscosity and structurization due to electrostatic interactions and the formation of a polyelectrolyte complex. This allowed electrospinning of defectless alginate nanofibers with an average diameter of 200–300 nm. The overall porosity of the bilayer scaffold was slightly lower than that of a chitosan monolayer, while the average pore size of up to 2 μm was larger for the bilayer scaffold. This high porosity promoted mesenchymal stem cell proliferation. The cells formed spherical colonies on the chitosan nanofibers, but formed flatter colonies and monolayers on alginate nanofibers. The fabricated chitosan/sodium alginate bilayer material was deemed promising for tissue engineering applications.

show abstract

“…Alginate, derived from brown sea algae, is a renewable, low-cost, environmentally friendly, linear polysaccharide. Being an abundant biopolymer and less toxic, it has been extensively studied for various applications, especially in biomedical research, drug delivery, pervaporation, and membrane filtration [13][14][15]. The swelling and degradation behavior of alginate in water limits the application of alginates in various industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Alginate–Halloysite Nanocomposite Aerogel: Preparation, Structure, and Oil/Water Separation Applications

Mohan

Krupa

2020

Biomolecules

View full text Add to dashboard Cite

Environmental remediation using green approaches for addressing various pollution-related issues, especially water pollution, is in high demand. Here, we designed an environmentally friendly, low-cost, and stable sodium alginate–halloysite clay composite aerogel (SAHA) for oil/water separation via a two-step synthesis procedure, including ionic crosslinking and freeze-drying. The as-prepared SAHA aerogels were characterized in detail by scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), and Fourier transformation infrared (FT-IR) spectroscopy. Characterization of the SAHA aerogels revealed a three-dimensional porous microstructure with uniformly dispersed halloysite nanotubes (HA) within the alginate matrix. The elemental composition of the hydrogels investigated using energy dispersive X-ray spectrometry (EDX) revealed the presence of minerals, such as magnesium, sodium, aluminum, and silicon in the SAHA aerogels. The presence of a hydrophilic alginate matrix combined with these unique morphological characteristics resulted in SAHA aerogels with underwater oleophobicity and excellent oil/water separation efficiency (up to 99.7%). The ease of fabrication, excellent oil/water separation, and multiple performances make the SAHA aerogel an interesting candidate for practical applications in water recycling.

show abstract

Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile

Cited by 45 publications

References 32 publications

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Cytocompatibility of Bilayer Scaffolds Electrospun from Chitosan/Alginate-Chitin Nanowhiskers

Alginate–Halloysite Nanocomposite Aerogel: Preparation, Structure, and Oil/Water Separation Applications

Contact Info

Product

Resources

About