Alginate di-aldehyde-modified metal–organic framework nanocarriers as delivery platform and adjuvant in inactivated pseudorabies vaccination

Abstract

Pseudorabies virus (PRV) is a highly contagious viral disease, and leads to severe financial losses to the breeding industry worldwide. The PRV is mainly controlled using live attenuated and inactivated...

Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

“…Compared to other dissolving microneedles, hyaluronic acid (HA)-, alginate-and chitosan-based microneedles have recently been used in cancer immunotherapy, due to their adjuvant functions. [90][91][92][93][94][95] Low-molecular-weight (LMW) HA (100-500 kDa) has been shown to engage a receptor complex comprising CD44 and toll-like receptors (TLRs), inducing cytokine release, and HA oligomers (with fewer than 10 HA disaccharides) have been reported to function as damage-associated molecular pattern (DAMP) molecules by specifically binding TLR2 and TLR4. 96,97 A HA-based microneedle array for the delivery of anti-PD1 antibody (aPD1) and 1-methyl-DL-tryptophan (1-MT) to melanoma was also produced 88 (Fig.…”