Alginate-coating of artemisinin-loaded cochleates results in better control over gastro-intestinal release for effective oral delivery

Shuddhodana,; Judeh, Zaher M. A.

doi:10.1016/j.jddst.2019.04.020

Cited by 19 publications

(2 citation statements)

References 50 publications

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“…Using Image J software, the average widths and lengths of these cylindrical structures were estimated to be 42.7±5.16 nm and 420.36±28.91 nm, respectively. Accordingly, SEM images confirm the external distinguishable shape of nanocochleates in which the length to width aspect ratio was markedly changed from spherical liposomes as previously reported [46,61].…”

Section: Morphological Examinationsupporting

confidence: 87%

Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal

El-Melegy

Eltaher

Gaballah

et al. 2021

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Morphological Examinationsupporting

confidence: 87%

Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal

El-Melegy

Eltaher

Gaballah

et al. 2021

European Journal of Pharmaceutics and Biopharmaceutics

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“…Phospholipids provide a robust nonpolar environment in the lipid region to accommodate hydrophobic cargoes. Second, some natural products such as chitosan (CS, pH‐responsive), [ 41 ] alginate (Alg, pH‐responsive), [ 42 ] and hyaluronic acid (HA, glucose‐responsive) [ 43 ] were used as stabilizers or stimuli‐responsive building blocks for lipid‐based NPs. Thus, a new carrier system is termed lipid‐polymer complex NPs, combining the properties of natural polymers and lipid NPs ( Figure a).…”

Section: Categories Of Stimulus‐responsive Core–shell Nanocarriersmentioning

confidence: 99%

Tailored Drug Delivery Platforms: Stimulus‐Responsive Core–Shell Structured Nanocarriers

Shi,

Zhang,

Zhu

et al. 2023

Adv Healthcare Materials

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Core‐shell structured nanocarriers have come into the scientific spotlight in recent years due to their intriguing properties and wide applications in materials chemistry, biology, and biomedicine. Tailored core‐shell structures to achieve desired performances has emerged as a research frontier in the development of smart drug delivery system. However, a systematic review on the design and loading/release mechanisms of stimulus‐responsive core‐shell structured nanocarriers is seldom available. This review starts with the categories of core‐shell structured nanocarriers with different means of drug payload, and then highlights the controlled release mechanism realized through stimulus‐response processes triggered under different environments. Finally, some multifaceted perspectives on the design of core‐shell structured materials as drug carriers are addressed. We hope this review could provide new enlightenments and prospects in the drug delivery field for further developing advanced and smart nanocarriers.This article is protected by copyright. All rights reserved

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Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition

Goo

Jin

Kim

et al. 2021

Bulletin Korean Chem Soc

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Lansoprazole (LSP)-loaded cochleates were developed using dimyristoyl phosphatidylcholine (DMPC) and cholesterol in the presence or absence of dicetyl phosphate (DCP). Cochleates containing DCP exhibited unique cylindrical morphologies, resulting in improved LSP loading and enhanced stability in an acidic environment. Thus, we suggest that the use of negatively charged components, such as DCP, is needed to formulate cochleates using a neutrally charged lipid such as DMPC.

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Alginate-coating of artemisinin-loaded cochleates results in better control over gastro-intestinal release for effective oral delivery

Cited by 19 publications

References 50 publications

Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal

Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal

Tailored Drug Delivery Platforms: Stimulus‐Responsive Core–Shell Structured Nanocarriers

Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition

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