Alginate/carboxymethyl chitosan composite gel beads for oral drug delivery

Hu, Yan; Peng, Jing; Ke, Lei; Zhao, Dan; Zhao, Haiyan; Xiao, Xincai

doi:10.1007/s10965-016-1022-5

Cited by 34 publications

(10 citation statements)

References 35 publications

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“…Secondly, the release mechanism differs. Many of the hydrogel-modified materials are pH responsive [28,29] or redox responsive, capable of responding to the presence of reducing compounds [30], while in a recent report a chitosan-based hydrogel was shown to exhibit a pH, temperature and salinity response [31]. This makes these nanogel materials interesting in terms of delivery to cancer cells.…”

Section: Introductionmentioning

confidence: 99%

The incorporation and controlled release of dopamine from a sulfonated β–cyclodextrin–doped conducting polymer

Hendy

Breslin

2019

J Polym Res

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Pyrrole was electropolymerised in the presence of sulfonated β-cyclodextrin to give a conducting polypyrrole film doped with the anionic cyclodextrin, PPy-sβ-CD. On reduction of the polymer film at −0.80 V vs SCE, high concentrations of dopamine (DA) were incorporated and the DA was subsequently released at a potential of 0.10 V vs SCE. Much higher levels of DA were incorporated and released at PPy-sβ-CD compared to polypyrrole films doped with smaller anions and doped with the larger para-toluene sulfonic acid. In addition to releasing higher concentrations of DA, the DA was less prone to oxidation and degradation in the presence of the sulfonated β-cyclodextrin. This was attributed to the formation of an inclusion complex between the protonated DA molecule and the anionic CD. The higher release rates were explained in terms of the immobile nature of the large CD and the high charge density with approximately 9 sulfonated groups attached to the rim of the CD cavity, which facilitated the uptake of high levels of DA. Approximately 6.0 μmol cm −2 of DA was released at 0.10 V vs SCE over 60 min on reducing the PPy-sβ-CD film for 30 min at −0.80 V vs SCE. Higher levels of 9.6 μmol cm −2 were obtained on increasing the reduction period to 60 min, while levels of 14.0 μmol cm −2 were achieved with thicker polymer films.

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Section: Introductionmentioning

confidence: 99%

The incorporation and controlled release of dopamine from a sulfonated β–cyclodextrin–doped conducting polymer

Hendy

Breslin

2019

J Polym Res

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“…To protect the drugs from the harsh environment in stomach before they can be absorbed in the intestine, pH-sensitive polysaccharide composites were developed. Protein drugs were encapsulated in inorganic carrier [59,60] and gel beads [61,62] to prolong their release. Series of pH-sensitive composite hydrogel composites of alginate and chitosan base were prepared with addition of attapulgite [61], bone ash [63], and other polymer-like pectin [64] that clearly showed their release dependence to pH condition.…”

Section: Drug Deliverymentioning

confidence: 99%

Polysaccharides as Composite Biomaterials

Wahab¹,

Razak²

2016

Composites From Renewable and Sustainable Materials

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Polysaccharidκ-basκd compositκ matκrials havκ bκκn thκ rκcκnt rκsκarch λocus in thκ iκld oλ matκrial sciκncκ and κnμinκκrinμ bκcausκ oλ thκir biocompatibility, rκnκwability, and sustainability. In this chaptκr, thκ authors atκmpt to rκviκw and discuss rκcκnt works in dκvκlopinμ polysaccharidκ-basκd compositκs in applications oλ tissuκ κnμinκκrinμ, druμ dκlivκry, and biopolymκr-basκd ilm packaμinμ. This chaptκr λocusκs on carraμκκnan, alμinatκ, chitosan, starch, and cκllulosκ compositκs. Introduction on thκsκ typκs oλ polysaccharidκs usκd as biomatκrials is briκly discussκd.Keywords: polysaccharidκ, biomatκrials, compositκs, rκnκwablκ, biocompositκs . Introduction "iomatκrials arκ dκinκd as matκrials that arκ usκd in thκrapκutic or diaμnostic procκdurκ by intκractions with componκnts oλ livinμ systκms [ ]. Ovκr thκ yκars, synthκtic polymκrs, cκramics, and mκtals wκrκ prκλκrrκd λor thκsκ typκs oλ applications duκ to thκir rκproducibility and bκtκr pκrλormancκ. Howκvκr, thκ μrowinμ concκrn on κnvironmκnt and hκalth sidκ-κfκcts havκ promotκd rκsκarchκs to look λor naturally dκrivκd polymκrs. "iomatκrials arκ dκsiμnκd to bκ inκrt and not to intκract in bioloμical systκms and not to causκ any harmλul chanμκs to thκ body. Polysaccharidκs arκ natural polymκrs λound in plant and orμanism. Thκ abundancκ oλ polysaccharidκ as a rκnκwablκ rκsourcκ promisκd its sustainability and κconomic valuκ λor biomatκrials. Thκir production cost is lκss than any synthκtic polymκrs and is κasily procκssablκ. Polysaccharidκs arκ polymκric carbohydratκ molκculκs consistinμ oλ lonμ chains oλ monosaccharidκ units bound by μlycosidic linkaμκs. Thκ λact that thκsκ polymκrs arκ κxtractκd λrom natural rκsourcκs has lκd to thκ imprκssion oλ μood biocompatibility and biodκμradability. Chκmically, nκarly all matκrials λrom plants arκ carbohydratκ in naturκ and composκd oλ rκpκatinμ unit oλ monosaccharidκs. Thus, thκy arκ nontoxic. Its biocompatiblκ naturκ is also atributκd to thκ structural similarity oλ μlycosaminoμlycans (G"Gs), which is a vital componκnt oλ κxtracκllular matrix in tissuκ. Thκrκ is an κmκrμinμ intκrκst in rκducinμ thκ amount oλ undisposablκ plastic wastκ that oλtκn lκads to sκrious κnvironmκntal problκm. Polysaccharidκs arκ potκntial altκrnativκ λor rκplacinμ convκntional pκtrolκum-basκd plastics which arκ ablκ to biodκμradκ naturally in soil. Polysaccharidκs arκ λamous λor thκir usκd in thκ λood and dairy industriκs. Howκvκr, its uniquκ structurκ and vκrsatilκ modiication can bκ κxplorκd λor othκr important iκlds.Polysaccharidκ can bκ catκμorizκd into structural and storaμκ polysaccharidκs. Examplκs oλ structural polysaccharidκs arκ cκllulosκ in plant and chitin in thκ shκlls oλ crustacκan, whilκ storaμκ polysaccharidκs includκ starch and μlycoμκn. Polysaccharidκs arκ prκsκnt in most livinμ orμanisms. In λact, polysaccharidκs comprisκ about % oλ thκ dry wκiμht oλ thκ total biomass [ ]. "lthouμh polysaccharidκ is advantaμκous as biomatκrials as thκy arκ morκ κcoλriκndly than pκtro-polymκrs, thκrκ arκ still critical drawbac...

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“…13,14 Among them, sodium alginate can be used as a matrix to prepare macroporous hydrogels. 15,16 Sodium alginate is a linear block copolymer comprising 1,4-linked b-D-mannuronic and a-L-guluronic acid residues. 17 It is considered to be non-toxic and biocompatible, 18 and its compatibility with drugs does not affect the pharmacological effects, showing that it has more natural advantages in the sustained and controlled release of drugs.…”

Section: Introductionmentioning

confidence: 99%