Alginate-based hybrid aerogel microparticles for mucosal drug delivery

Gonçalves, V.S.S.; Gurikov, Pavel; Poejo, Joana; Matias, Ana A.; Heinrich, Stefan; Duarte, Catarina M.M.; Смирнова, Ирина

doi:10.1016/j.ejpb.2016.07.003

Cited by 109 publications

(72 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Aerogels are the lightest porous solid nanomaterials produced by the 2-stages sol-gel method through substitution of liquid in gel pores with air [1,2]. Since the preparation of the first aerogels by Kistler in 1931, these substances have found numerous applications in thermal insulation [3][4][5], catalyst supports [6,7], space engineering [4], humidity sensors [8], wastewater treatment [1,4], nuclear fusion reactors [6], electrodes [9], electrical circuits (due to their low dielectric constant) [8], solar energy collectors [4], super high-density capacitors [3,4], adsorbent (due to their high porosity and surface area) [9], and carriers for delivery systems [10][11][12]. About 22% of biomedical applications of aerogels are related to drug delivery [13].…”

Section: Introductionmentioning

confidence: 99%

“…Mehling et al (2009) synthesized polysaccharide aerogel from starch and alginate materials and showed that polysaccharide aerogels have a high potential as drug carriers [14]. Gonçalves et al (2016) synthesized alginate aerogel and alginate-pectin and alginate-carrageenan hybrid aerogel with a specific surface area higher than 300 m 2 /g through an emulsion-gelation method combined with drying by supercritical carbon dioxide [10]. Chang et al (2010) synthesized starch-derived carbon aerogels by ambient pressure drying method [21].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mesoporous starch aerogels production as drug delivery matrices: synthesis optimization, ibuprofen loading, and release property

Mohammadi¹,

Moghaddas²

2020

Turk J Chem

View full text Add to dashboard Cite

The aim of this work was to prepare biodegradable starch aerogels as drug carriers. The effective parameters in the synthesis and the optimal values of these parameters were determined using Minitab experimental design software.Ibuprofen was selected as a model drug for the dissolution study and loaded into optimized aerogel during the last solvent exchange step. The Fourier Transform Infrared Spectroscopy (FTIR) analysis showed that ibuprofen has been successfully loaded into the aerogel matrix without any effect on the aerogel nature. The drug loading was calculated to be 29%.The isotherm of ibuprofen adsorption into aerogels matrices followed from the Freundlich isotherm. The in vitro release tests of crystalline ibuprofen and ibuprofen-loaded potato starch aerogel were investigated with simulated gastric and intestinal fluids in USP 2 apparatus. It was shown that the dissolution rate of ibuprofen could be dramatically changed.Also, an improvement in the dissolution rate of ibuprofen was achieved by performing the dissolution test first in the gastric medium for 120 min and then in the intestinal medium for up to 270 min. A higher release rate (100%) was observed at the end of the in vitro experiment.Recently, polysaccharide-based aerogels have been synthesized and scaled-up (from bench scale to pilot scale) for drug delivery applications [16]. Polysaccharides, as a class of biopolymers, are composed of single or more simple sugar monomers. Due to their availability, recyclability, nontoxicity, good biological performance, and enzymatic degradation they have found applications in pharmaceuticals, drug carriers, and tissue engineering [17][18][19][20]. Polysaccharides can convert to hydrogel at a supersaturated concentration in the presence of physical or * Correspondence: jafar.moghaddas@sut.ac.ir This work is licensed under a Creative Commons Attribution 4.0 International License.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mesoporous starch aerogels production as drug delivery matrices: synthesis optimization, ibuprofen loading, and release property

Mohammadi¹,

Moghaddas²

2020

Turk J Chem

View full text Add to dashboard Cite

show abstract

“…Resulting emulsions are stabilized by using surfactants. Subsequently, gelation of the droplets (dispersed phase of the emulsion) is induced by addition of a solution of the gelling agent [9]. Principally, the scale-up of the emulsion gelation method for production of large amounts of aerogel particles is possible.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-Based Aerogel Bead Production via Jet Cutting Method

et al. 2018

View full text Add to dashboard Cite

The aim of this work is to develop a method to produce spherical biopolymer-based aerogel particles, which is capable for scale-up in the future. Therefore, the jet cutting method is suggested. Amidated pectin, sodium alginate, and chitosan are used as a precursor (a 1–3 wt. % solution) for particle production via jet cutting. Gelation is realized via two methods: the internal setting method (using calcium carbonate particles as cross-linkers and citric and acidic acid for pH adjustment) and the diffusion method (in calcium chloride solutions). Gel particles are subjected to solvent exchange to ethanol and consequent supercritical drying with CO2. Spherical aerogel particles with narrow particle size distributions in the range of 400 to 1500 µm and a specific surface area of around 500 m2/g are produced. Overall, it can be concluded that the jet cutting method is suitable for aerogel particle production, although the shape of the particles is not perfectly spherical in all cases. However, parameter adjustment might lead to even better shaped particles in further work. Moreover, the biopolymer-based aerogel particles synthesized in this study are tested as humidity absorbers in drying units for home appliances, particularly for dishwashers. It has been shown that for several cycles of absorption and desorption of humidity, aerogel particles are stable with an absorption capacity of around 20 wt. %.

show abstract

“…98.5 V/V% to ensure single phase conditions during subsequent supercritical drying (Subrahmanyam et al, 2015). The samples were dried with supercritical CO 2 at 45°C and 140 bar using a continuous flow process in a high pressure autoclave, as described elsewhere (Goncalves et al, 2016;Smirnova, Mamic, & Arlt, 2003). Altogether, four different aerogel samples were produced as summarized in Table 1.…”

Section: Synthesis Of Fe(iii)-alginate Aerogel Beadsmentioning

confidence: 99%

“…Similarly to the hydrogels, these aerogels are versatile biomaterials which were recently introduced into the field of drug delivery research Veronovski, Novak, & Knez, 2012). The oral (Garcia-Gonzalez, Jin, Gerth, Alvarez-Lorenzo, Mehling, Smirnova, Guenther, & Neubert, 2009) and mucosal (Goncalves et al, 2016) delivery applications of various active pharmaceutical ingredients, including fat-soluble vitamins (Pantic, Knez, & Novak, 2016) have been investigated. Layered (Veronovski, Knez, & Novak, 2013) and core-shell (Ulker & Erkey, 2014) formulations have also been developed aiming to fine-tune the release kinetics.…”

Section: Introductionmentioning

confidence: 99%

A redox strategy to tailor the release properties of Fe(III)-alginate aerogels for oral drug delivery

Veres

Sebők

Dékány

et al. 2018

Carbohydrate Polymers

View full text Add to dashboard Cite

Iron(III)-crosslinked alginate aerogel beads (d = 3-5 mm) were prepared and loaded with ibuprofen by using the technique of adsorptive deposition from supercritical CO 2 . Additional formulations were prepared where the aerogels were co-impregnated by ibuprofen and ascorbic acid. The release of ibuprofen from the Fe(III)-alginate is much faster in pH = 7.4 (PBS) than in pH = 2.0 (HCl), which can be explained by the faster dissolution and higher swelling of the alginate matrix in PBS. By decreasing the size of the beads and using a higher G content alginate the release rate could be slightly increased. A marked acceleration of drug release was achieved in both HCl and PBS by incorporating ascorbic acid into the Fe(III)-alginate aerogel preparations. The explanation is that in aqueous media ascorbic acid in situ reduces the crosslinking Fe(III) to Fe(II). The latter does not interact strongly with alginate, which promotes the hydration of the chains, thus the erosion and dissolution of the carrier matrix.

show abstract

Alginate-based hybrid aerogel microparticles for mucosal drug delivery

Cited by 109 publications

References 55 publications

Mesoporous starch aerogels production as drug delivery matrices: synthesis optimization, ibuprofen loading, and release property

Mesoporous starch aerogels production as drug delivery matrices: synthesis optimization, ibuprofen loading, and release property

Polysaccharide-Based Aerogel Bead Production via Jet Cutting Method

A redox strategy to tailor the release properties of Fe(III)-alginate aerogels for oral drug delivery

Contact Info

Product

Resources

About