Alginate based bilayer hydrocolloid films as potential slow-release modern wound dressing

Thu, Hnin Ei; Zulfakar, Mohd Hanif; Ng, Shiow Fern

doi:10.1016/j.ijpharm.2012.05.044

Cited by 227 publications

(105 citation statements)

References 38 publications

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“…Along with hydrophobic polymers, hydrophilic films insoluble in wound exudate are used, for example, copolymers of a acrylate with vinyl acetate and other monomers, or films of polyvinyl alcohol and polyvinylpyrrolidone. [12,13] Isolation films of the second group, formed directly on the wound surface, are represented in the form of aerosol compositions, when applied to the wound for 1-2 min, due to evaporation of the solvent, a dressing is created in the form of a film.…”

Section: Resultsmentioning

confidence: 99%

“…The standard technology is pouring on a surface. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Preparing gelling solution, the first stage of which is the dissolution stage precedes pouring. Depending on the properties of the ingredients, it is possible to dissolve hydrophilic polymers in water separately, heating it, and to dissolve active and auxiliary substances in matching solvents with further combining the formed solutions; or to dissolve auxiliary substances insolvent or a mixture of solvents, and then adding active pharmaceutical ingredients to this solution.…”

Section: Technological Processmentioning

confidence: 99%

“…A kind of a dosage form for treating patients with skin defects, which are the results of purulent infection of soft tissues, are wound dressings. [2,7,12,13,36] The correct choice of a wound dressing with a certain mechanism of action can significantly improve the effectiveness of the purulent wounds treatment. Nowadays, more than 300 types of wound dressings are used in clinical practice.…”

Section: Application Of Films In Medicinementioning

confidence: 99%

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Хохленкова

2017

AJP

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Introduction: Nowadays, biopolymers and biomaterials are an actively developing field, interesting both for specialists from various fields of science and for society at large. The range of polymers of both natural and synthetic origin is constantly expanding, but only a few of them are used in pharmaceutical production and medical practice. Due to the composition of polymers and active pharmaceutical ingredient, films are a promising form for applying in dentistry, ophthalmology, surgery, and other fields of medicine. Materials and Methods: In the work marketing and economic research methods are used to ground social and medical practicability of developing new dental products for local treatment. Results and Discussions: Based on the data of modern scientific literature, the requirements for medicinal films are outlined, their classification is given. Approaches to the choice of active and auxiliary substances in the process of developing new film formulations are described. The prospects of using films in surgery, dentistry, ophthalmology, and dermatology are shown. Conclusions: Based on the review, polymer films have been classified, and the requirements for the given dosage form have been defined. Approaches to selecting active and auxiliary ingredients have been considered. The main aspects of the technological process for the preparation of films are described. The ways of rational application of films in medical practice have been highlighted.

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Section: Resultsmentioning

confidence: 99%

Section: Technological Processmentioning

confidence: 99%

Section: Application Of Films In Medicinementioning

confidence: 99%

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Хохленкова

2017

AJP

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“…Traditional dressings have been largely replaced by modern dressings, which are capable of creating and maintaining a moist environment in the wound bed, ideally suited for cellular migration and proliferation [81,115,124,150,151]. A great deal of interest has been focused on advanced dressings with the ability to release bioactive substances directly into the wound bed [6,75,161,192]. Bioengineered skin substitutes represent the most advanced products available for skin wounds, allowing the regeneration of both epidermal and dermal skin layers [23,50,138,176].…”

Section: Therapeutic Options For Skin Reconstructionmentioning

confidence: 99%

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

et al. 2017

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Bioprinting technologies are powerful additive biofabrication techniques to produce cellular constructs for skin tissue engineering owing to their unique ability to precisely pattern living and non-living materials in predefined spatial locations. This unique feature, combined with the computer controlled printing and medical imaging techniques, enable researchers and clinicians to generate patient specific constructs partly replicating the intricate compositional and architectural organization of the skin. Bioprinting has been used to automatically dispense hydrogels with skin cells located in prescribed sites that promote skin formation in vitro and in vivo. Current skin bioprinting approaches mostly rely on the sequential printing of fibroblasts and keratinocytes embedded within a homogeneous hydrogel. Although such approaches have already been translated to pre-clinical scenarios, they still present limitations in terms of fully replicating the cellular and extracellular matrix (ECM) heterogeneity in native skin. The success of bioprinting for skin repair strongly depends on the design of printable bioinks capable of supporting the function of printed cells and stimulating the production of new ECM components. To better mimic the human skin, novel developments in dedicated bioprinting technologies, in the design of bioinks, as well as in the printing of vascularised constructs are necessary. This paper presents an overview regarding the use of bioprinting for skin tissue engineering applications. The operating principles of bioprinting technologies are outlined along with requirements of printed skin constructs. Finally, preclinical results are summarized and future perspectives for the field are highlighted.

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“…Ferreira et al [13] who classified bilayer films of FucoPol and CHI showed favorable optical, mechanical, and barrier properties than FucoPol monolayer films. Thu et al [14] reported that bilayer films based on alginate can be used as slow-release wound healing vehicles, in which the drug-free inner layer acts as a rate-controlling membrane.…”

Section: Introductionmentioning

confidence: 99%

Effect of bilayer coating composed of polyvinyl alcohol, chitosan, and sodium alginate on salted duck eggs

Jiang

Zhuang

Zhong

et al. 2018

International Journal of Food Properties

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The composite bilayer film based on polyvinyl alcohol, sodium alginate, and chitosan were developed in this study, and the effects of the related coating on internal-quality changes of salted duck eggs (SDEs) during storage were determined. The results showed that the overall properties of the bilayer film were better than those of monolayer films, including storage stability. Coatings could significantly (p < 0.05) reduce quality deterioration of SDEs such as water loss, oil exudation, and gritty. The bilayer coating was more effective in inhibiting the increase of egg yolk pH and total bacterial counts than monolayer coatings. After storage for 60 days, water content of bilayer coated SEDs was 19.7% higher than that of the control SDEs, oil exudation was 38% higher, and gritty texture was 27.9% higher. Moreover, bilayer coating could prolong the shelf life of SDEs to more than 60 days at 25°C and 50% relative humidity according to the results of total bacterial count experiment, while the shelf life of control SDEs was less than 45 days. This study indicated the potential application of bilayer composite coating for preservation of SDEs. ARTICLE HISTORY

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Alginate based bilayer hydrocolloid films as potential slow-release modern wound dressing

Cited by 227 publications

References 38 publications

Untitled

Untitled

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

Effect of bilayer coating composed of polyvinyl alcohol, chitosan, and sodium alginate on salted duck eggs

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