Alginate and Chitosan Gel Nanoparticles for Efficient Protein Entrapment

Masalova, O.; Kulikouskaya, Viktoryia; Shutava, Tatsiana G.; Agabekov, V. E.

doi:10.1016/j.phpro.2012.12.010

Cited by 41 publications

(23 citation statements)

References 16 publications

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“…The use of other anionic species interacting with CS has also been assayed. This is the case of sodium sulfate, our own experience with magnesium sulfate and CS to obtain nanoparticles and microparticles by IG (data not shown), and the interaction of CS with another polymer: sodium alginate …”

Section: Most Used Species For Igmentioning

confidence: 91%

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Pedroso‐Santana

Fleitas‐Salazar

2020

Polymer International

159

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The encapsulation of drugs inside polymeric nanoparticles/microparticles is a strategy currently employed in the search for new and more effective therapies. The use of biocompatible and biodegradable polymers gives several advantages to these formulations. Protection of the active principals against the action of environmental and physiological agents, the reduced number of doses and a subsequent decrease in drug-related adverse effects, and increased bioavailability are some of these advantages. Several methods and materials are now used to synthesize nanoparticles/microparticles for biomedical applications, from carbon-derived structures to metallic and lipid particles. However, among the methods using polymers, ionotropic gelation is one of the more affordable and easier procedures to perform in daily laboratory work. In this mini-review, we address relevant characteristics of ionotropic gelation, beginning with basic aspects of the technique, which reagents and conditions are commonly used, the factors affecting the stability of the formulation, the advantages and disadvantages of the method and some principal characterization techniques for the nanoparticulate/microparticulate formulation. Finally, we conclude with a few important considerations.

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Section: Most Used Species For Igmentioning

confidence: 91%

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Pedroso‐Santana

Fleitas‐Salazar

2020

Polymer International

159

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“…Zeta potential and surface charge of nanoparticles was negative at all batches but at high stirring time (90 min) and stirring speed (1000 rpm), positive charges of both chitosan and calcium moieties would be permitted to complex with anionic moieties of alginate which reduced negative surface charge of alginate core and then increase zeta potential 26 . Order of chitosan addition (before or after crosslinker)…”

Section: Characterization Of Optimum Conditions Affecting Nanoparticlmentioning

confidence: 95%

Untitled

2018

IJPSR

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The overall objective of this research is to improve the oral bioavailability of insulin through encapsulation in nanoparticles formulated by "ionotropic pre-gelation followed by polyelectrolyte complexation technique". The preparation variables such as initial drug concentration, polymer: polymer ratios, crosslinker concentration, stirring speed, stirring time, pH of drug / polymer mixture were investigated to study the effect of variables on nanoparticles size and drug entrapment efficiency. The optimum formula of insulin-loaded nanoparticles was tested for insulin release in three different pH media. The pharmacological activity of insulin-loaded nanoparticles was evaluated following oral dosage in diabetic rats and then study whether insulinloaded nanoparticles would induce hypoglycemic effect after oral administration to diabetic rats. The optimum formula of nanoparticles improved insulin release characteristics. Thus, the polymer matrix provided protection for insulin in acidic gastric medium and allowed prolonged insulin release in alkaline intestinal medium. In-vivo results indicated that nanoparticles kept insulin bioactivity and its hypoglycemic effect after oral administration of insulinloaded nanoparticles to diabetic rat model. It was found that natural biodegradable nanoparticles are a promising device for oral insulin delivery.

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“…Examples include heating globular proteins under moderate electrostatic interactions (for example, heating β-lactoglobulin at approximately pH 4.6-4.8 or 5.8-6.2) 54,55 , electrostatic complexation between oppositely charged polyions and antisolvent nanoprecipitation (for example, evaporating ethanol from the zein aqueousalcohol solution) 56 . Microgels can also be produced by crosslinking gelling polymers at concentrations below those required to form a macroscopic gel 57 . The simplest top-down approach consists of grinding the macroscopic gels, but the resulting gel particles are typically highly irregular and polydisperse in shape 58 .…”

Section: Gel Fabricationmentioning

confidence: 99%

Design principles of food gels

Cao¹,

Mezzenga²

2020

Nat Food

329

169

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Naturally sourced gels from food biopolymers have advanced in recent decades to compare favourably in performance and breadth of application to their synthetic counterparts. Here, we comprehensively review the constitutive nature, gelling mechanisms, design approaches, and structural and mechanical properties of food gels. We then consider how these food gel design principles alter rheological and tribological properties for food quality improvement, nutrient-modification of foods while preserving sensory perception, and targeted delivery of drugs and bioactives within the gastrointestinal tract. We propose that food gels may offer advantages over their synthetic counterparts owing to their source renewability, low cost, biocompatibility and biodegradability. We also identify emerging approaches and trends that may improve and expand the current scope, properties and functionalities of food gels and inspire new applications.

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Alginate and Chitosan Gel Nanoparticles for Efficient Protein Entrapment

Cited by 41 publications

References 16 publications

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Untitled

Design principles of food gels

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