Algerian propolis extracts: Chemical composition, bactericidal activity and in vitro effects on gilthead seabream innate immune responses

Soltani, El-Khamsa; Cerezuela, Rebeca; Charef, Noureddine; Mezaache-Aichour, Samia; Esteban, M. Ángeles; Zerroug, M. M.

doi:10.1016/j.fsi.2017.01.009

Cited by 46 publications

(23 citation statements)

References 69 publications

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“…Algeria's distinctive climate, fauna, and flora contribute to its great biodiversity (Soltani et al, 2017). According to some studies, Algerian propolis has a wide range of biological properties, including antitumor (Benguedouar et al, 2016), bactericidal (Soltani et al, 2017), renoprotective (Boutabet et al, 2011), and antioxidant activities (Piccinelli et al, 2013;Mouhoubi-Tafinine, Ouchemoukh, Tamendjari, 2016) and it contains several anti-cancer phenolic components (Boutabet et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity

Brihoum

Maiza

Sahali

et al. 2018

Braz. J. Pharm. Sci.

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The purpose of our study was to divulge the antiproliferative effect of an ethanolic extract of Algerian propolis (EEP) in the human lung adenocarcinoma cell line (A549) and reveal the chemopreventive role against benzo(a)pyrene-induced lung carcinogenesis in albino Wistar rats. Cytotoxicity of EEP was evaluated using the MTT assay and cell adhesion in A549 cells. Moreover, rats were given 25 mg/kg of propolis for 5 days before induction of experimental lung cancer by a single intraperitoneal dose of 200 mg/kg benzo(a)pyrene. Body weight, lung weight, lipid peroxidation, marker enzymes, and enzymatic and non-enzymatic antioxidants were estimated. The EEP demonstrated an inhibitory effect on proliferation of A549 at 24 and 72 hours in a dose-dependent manner and blocked adhesion of the cells by fibrinogen. Moreover, EEP reduced the oxidative stress generated by benzo(a)pyrene. The pre-treatment showed that enzymatic and non-enzymatic antioxidants increased and lipid peroxidation decreased. A histological analysis further supported these findings and showed a decrease in the number of side effects. These results are particularly important for both clinical applications of propolis and the possibility for its use as a potential chemotherapeutic agent.

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Section: Introductionmentioning

confidence: 99%

Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity

Brihoum

Maiza

Sahali

et al. 2018

Braz. J. Pharm. Sci.

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“…Those samples were also rich on di-and triterpenic compounds. [118,119] In contrast, in Graikou et al [61] finding, it was reported that Algerian propolis belong to a group of propolis with relatively high amounts of flavonoids and low diterpene content. In conclusion, the results obtained by diverse researcher teams reveal a co-existence of diterpenic-rich propolis and propolis rich in flavonoids.…”

Section: Levantine Coastmentioning

confidence: 92%

“…[74] It was found that propolis samples from Tiaret, Tlemcen, Sidi bel Abbes and Mascara, Algeria, were active against Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis and Bacillus cereus), and inactive against Gram negative bacteria (Pseudomonas aeruginosa, E. coli). [203,204] In Soltani et al [118] study, it was demonstrated the immunomodulatory activity and the bactericidal activity of Algerian propolis against im-portant bacterial pathogens in sea bream, and was suggested that propolis could be a source of new natural biocides and/or immunomodulators in aquaculture practice. In addition, it is noteworthy that caffeic acid derivatives from propolis from Beni Belaïd area had the capacity to inhibit Stromelysin-1 enzyme enrolled in collagenolytic and elastolytic cascades, leading to cutaneous intrinsic and extrinsic aging.…”

Section: Northern African Coastmentioning

confidence: 98%

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

El-Guendouz

Lyoussi

Miguel

2019

Chemistry & Biodiversity

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This review updates the information upon the chemical composition of propolis from all Mediterranean countries as well as their biological properties and applications. The non‐volatile fraction of propolis was characterized by the presence of phenolic acids and their esters and flavonoids. Nevertheless, in some countries, diterpenes were also present: Sicily (Italy), Croatia, Malta, Creta (Greece), Turkey, Cyprus, Egypt, Libya, Algeria and Morocco. The volatile fraction of propolis was characterized by the presence of benzoic acid and its esters, mono‐ and sesquiterpenes, being the oxygenated sesquiterpene β‐eudesmol characteristic of poplar propolis, whereas the hydrocarbon monoterpene α‐pinene has been related with the presence of conifers. Regardless the chemical composition, there are common biological properties attributed to propolis. Owing to these attributes, propolis has been target of study for applications in diverse areas, such as food, medicine and livestock.

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“…Then the absorbance of the samples was measured at 620 nm (BMG, Star GalaxyFluoro) at 30 minute intervals for 24 h at 25 ° C. Samples without bacteria were used as blanks (negative control). Samples without H were used as positive control 3 .…”

Section: Antibacterial Activity Evaluationmentioning

confidence: 99%

In Silico Toxicological, Anti-Tubercular Effect Evaluation And In Vitro Marine Pathogenic Bacteria Inhibition of N-[(3-Chloro-4-Nitro-Phenyl)Methyleneamino]Pyridine-4-Carboxamidine

Mokhnache

Soltani

Madoui

et al. 2019

J. Drug Delivery Ther.

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The hydrazone; N-[(3-chloro-4-nitro-phenyl) methyleneamino] pyridine-4-carboxamidine (H) was selected for in silico toxicological and in vitro bactericidal studies. Toxicological investigation was carried out using software program, such as eMolTox and Gusar, for the toxic substructure determination, and acute rat toxicity prediction respectively. In vitro bactericidal effect evaluation was investigated using tow marine pathogenic bacteria; Vibrio anguillarum and Photobacterium damselae. Computational results determinate toxicophores of (H), which are nitro-aromatic part, hydrazine group, and quaternary carbon, were predicted as responsible for Idiosyncratic toxicity metabolic activation, covalent bond with DNA, and hepatotoxicity respectively. In addition, the predicted LD50 of (H) are 1086, 244, 1816, and 823.40 mg/kg in intraperitenial, intravenous, oral and subcutaneous administration respectively. For bactericidal results, H exhibited an excellent effect with inhibition percentages of 98.65 and 98.83% at the concentrations of 1000 and 500 µg/mL against Vibrio anguillarum respectively, the same effect was demonstrated against Photobacterium damselae with inhibition percentages of 97.74 and 97.98 % at the same concentrations. For anti-tubercular effect prediction, results revealed that H has an excellent effect with probability percentage of 84.6%. Keyword: Hydrazone, toxicophore, LD50, Anti-tubercular, Vibrio anguillarum, Photobacterium damselae.

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Algerian propolis extracts: Chemical composition, bactericidal activity and in vitro effects on gilthead seabream innate immune responses

Cited by 46 publications

References 69 publications

Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity

Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

In Silico Toxicological, Anti-Tubercular Effect Evaluation And In Vitro Marine Pathogenic Bacteria Inhibition of N-[(3-Chloro-4-Nitro-Phenyl)Methyleneamino]Pyridine-4-Carboxamidine

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