Algal sulfated polysaccharide-based hydrogels enhance gelling properties and in vitro wound healing compared to conventional hydrogels

Huang, Weixuan; Chen, Yang; Jin-hong, HU; Yao, Wanzi; You, Lijun; Cheung, Peter C.K.

doi:10.1016/j.algal.2022.102740

Cited by 8 publications

(10 citation statements)

References 47 publications

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“…The high water content, strong adaptability, and high porosity of hydrogel make it an ideal candidate for wound dressing. By comparing the swelling properties of hydrogels, the water retention capacity of hydrogels could be verified to ensure that they could provide a moist healing environment . The porous structure of the hydrogel could provide the best gas exchange and nutrition supply for cells, promoting effective wound repair.…”

Section: Resultsmentioning

confidence: 99%

MMP-Responsive Nanoparticle-Loaded, Injectable, Adhesive, Self-Healing Hydrogel Wound Dressing Based on Dynamic Covalent Bonds

Zhang,

Luo,

et al. 2023

Biomacromolecules

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Developing a multifunctional hydrogel wound dressing with good injectability, self-healing, tissue adhesion, biocompatibility, and fast skin wound healing efficiency remains challenging. In this work, an injectable adhesive dopaminefunctionalized oxidized hyaluronic acid/carboxymethyl chitosan/ collagen (AHADA/CCS/Col) hydrogel was constructed. The Schiff dynamic bond between AHADA and CCS, the N−Ag−N bond between CCS and Ag ions, and the S−Ag−S dynamic bond between sulfhydryl-modified collagen (ColSH) and Ag ions allowed the hydrogel to be both injectable and self-healing. Moreover, the aldehyde groups and catechol groups presented in the hydrogel could generate force with several groups on the tissue interface; therefore, the hydrogel also had good tissue adhesion. In vitro experiments proved that this hydrogel exhibited good biocompatibility and could promote cell proliferation. Additionally, curcumin (Cur)-loaded gelatin nanoparticles (Cur@Gel NPs) were prepared, which could respond to matrix metalloproteinases (MMPs) and controllably release Cur to hasten wound healing efficiency. Animal experiment results showed that this AHADA/CCS/Col hydrogel loaded with Cur@Gel NPs promoted wound repairing better, indicating its potential as a wound dressing.

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Section: Resultsmentioning

confidence: 99%

MMP-Responsive Nanoparticle-Loaded, Injectable, Adhesive, Self-Healing Hydrogel Wound Dressing Based on Dynamic Covalent Bonds

Zhang,

Luo,

et al. 2023

Biomacromolecules

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show abstract

“…The equilibrium swelling ratios of the Blank group (chitosan-polymer polyvinyl alcohol hydrogel) and the Positive group (gelatin sponge) were 8.49 ± 0.67 and 8.69 ± 0.25, respectively, which were significantly lower than LJP-gels. Traditional hydrogels (Blank and Positive) were single network structures, while LJP-based hydrogels were proved to be double network structures in our previous study [ 24 ]. Compared with traditional hydrogels, LJP-gels had obvious advantages in swelling properties because the hydrogel structure with a double network was more stable and more porous, which was more conducive to absorbing water molecules.…”

Section: Resultsmentioning

confidence: 99%

“…Polysaccharides from Laminaria japonica (named LJP) were extracted by the hot water extraction method according to our previous report [ 24 ]. Then, to obtain LJP with different molecular weights, they were prepared from Laminaria japonica according to our previously reported method with some modifications [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

“…The LJP-based hydrogels were prepared according to the previous report [ 24 ] with the same volume of the following solutions: 0.5% ( w/w ) LJP solution, 1% ( w/w ) chitosan solution (adjust pH value to 3.0 with 6 M hydrochloric acid), and 5% (w/w) polyvinyl alcohol solution (bath in 70 °C). Chitosan solution was cross-linked with LJP by 5-min continuous stirring.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous study, polysaccharides extracted from Laminaria japonica (LJP) were proved to be the most potential algae polysaccharides to form wound dressing hydrogels [ 24 ]. Therefore, in this study, LJP were treated with UV/H 2 O 2 degradation to form polysaccharides with different molecular weights.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Molecular Weight of Polysaccharides from Laminaria japonica to LJP-Based Hydrogels: Anti-Inflammatory Activity in the Wound Healing Process

et al. 2022

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In this study, polysaccharides from Laminaria japonica (LJP) were produced by the treatment of ultraviolet/hydrogen peroxide (UV/H2O2) degradation into different molecular weights. Then, the degraded LJP were used to prepare LJP/chitosan/PVA hydrogel wound dressings. As the molecular weight of LJP decreased from 315 kDa to 20 kDa, the swelling ratio of the LJP-based hydrogels rose from 14.38 ± 0.60 to 20.47 ± 0.42 folds of the original weight. However, the mechanical properties of LJP-based hydrogels slightly decreased. With the extension of the UV/H2O2 degradation time, the molecular weight of LJP gradually decreased, and the anti-inflammatory activities of LJP-based hydrogels gradually increased. LJP that were degraded for 60 min (60-gel) showed the best inhibition effects on proinflammatory cytokines, while the contents of TNF-α, IL-6, and IL-1β decreased by 57.33%, 44.80%, and 67.72%, respectively, compared with the Model group. The above results suggested that low Mw LJP-based hydrogels showed great potential for a wound dressing application.

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Effects of processing on the physicochemical characteristics and health benefits of algae products: Trade-offs among food carbon footprint, nutrient profiles, health properties, and consumer acceptance

Chen,

You,

Sun-Waterhouse

2024

Trends in Food Science & Technology

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Algal sulfated polysaccharide-based hydrogels enhance gelling properties and in vitro wound healing compared to conventional hydrogels

Cited by 8 publications

References 47 publications

MMP-Responsive Nanoparticle-Loaded, Injectable, Adhesive, Self-Healing Hydrogel Wound Dressing Based on Dynamic Covalent Bonds

MMP-Responsive Nanoparticle-Loaded, Injectable, Adhesive, Self-Healing Hydrogel Wound Dressing Based on Dynamic Covalent Bonds

Influence of Molecular Weight of Polysaccharides from Laminaria japonica to LJP-Based Hydrogels: Anti-Inflammatory Activity in the Wound Healing Process

Effects of processing on the physicochemical characteristics and health benefits of algae products: Trade-offs among food carbon footprint, nutrient profiles, health properties, and consumer acceptance

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