Algal metabolites: Paving the way towards new generation antidiabetic therapeutics

Kaushik, Anshul; Sangtani, Rimjhim; Parmar, Hamendra Singh; Bala, Kiran

doi:10.1016/j.algal.2022.102904

Cited by 5 publications

(2 citation statements)

References 340 publications

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“…The exploration of algae as a source of natural products has revealed a vast diversity of bioactive compounds, including polysaccharides, polyphenols, pigments, and peptides, which exhibit potential antidiabetic effects [ 13 , 33 , 44 ]. Mechanistic insights into the therapeutic properties of algae-derived compounds have shed light on their ability to regulate blood glucose levels, enhance insulin secretion and sensitivity, and inhibit carbohydrate-digesting enzymes [ 33 , 154 , 169 ]. Furthermore, algae-based interventions have shown promise in preventing and managing diabetic complications such as retinopathy and nephropathy [ 33 , 36 , 104 , 111 ].…”

Section: Discussionmentioning

confidence: 99%

Algae-Derived Natural Products in Diabetes and Its Complications—Current Advances and Future Prospects

Pereira,

Valado

2023

Life

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Diabetes poses a significant global health challenge, necessitating innovative therapeutic strategies. Natural products and their derivatives have emerged as promising candidates for diabetes management due to their diverse compositions and pharmacological effects. Algae, in particular, have garnered attention for their potential as a source of bioactive compounds with anti-diabetic properties. This review offers a comprehensive overview of algae-derived natural products for diabetes management, highlighting recent developments and future prospects. It underscores the pivotal role of natural products in diabetes care and delves into the diversity of algae, their bioactive constituents, and underlying mechanisms of efficacy. Noteworthy algal derivatives with substantial potential are briefly elucidated, along with their specific contributions to addressing distinct aspects of diabetes. The challenges and limitations inherent in utilizing algae for therapeutic interventions are examined, accompanied by strategic recommendations for optimizing their effectiveness. By addressing these considerations, this review aims to chart a course for future research in refining algae-based approaches. Leveraging the multifaceted pharmacological activities and chemical components of algae holds significant promise in the pursuit of novel antidiabetic treatments. Through continued research and the fine-tuning of algae-based interventions, the global diabetes burden could be mitigated, ultimately leading to enhanced patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Algae-Derived Natural Products in Diabetes and Its Complications—Current Advances and Future Prospects

Pereira,

Valado

2023

Life

View full text Add to dashboard Cite

show abstract

“…Algae extracts have a number of biological activities such as, antioxidant [68] , [69] , [70] , [71] , [72] , [73] , antimicrobial [73] , [74] , [75] , [76] , [77] , anticancer [78] , [79] , [80] , [81] , [82] , antidiabetic [ 72 , 83 , 84 , 85 ], antihypertensive [ 86 , 87 ], and others. The presence of polysaccharides, polypeptides, phenols, and pigments in algae results in biological activities, many of which have health benefits (such as antioxidant, anti-inflammatory, antimicrobial, and anticoagulant properties).…”

Section: Lactic Acid Fermentationmentioning

confidence: 99%