Algal Metabolites and Phyco-Medicine

Vidhyanandan, Lakshmi Mangattukara; Kumar, Suresh; Sukumaran, Swapna Thacheril

doi:10.1007/978-981-15-5136-9_13

Cited by 5 publications

(2 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PTs act as potent antioxidant molecules and exhibit promising anticancer properties (Pradhan, Nayak, Bhuyan, Patra, Behera, et al, 2022). According to several reports, brown algae are abundant sources of PTs, presenting a wide range of biological activities (Pal & Raj, 2021; Vidhyanandan et al, 2020). Nonetheless, PT anticancer activity depends on extraction method and structure of the phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and chemotherapeutic efficacies of seaweed‐derived phlorotannins in cancer treatment: A review regarding novel anticancer drugs

Pradhan

2023

Phytotherapy Research

View full text Add to dashboard Cite

The ineffectiveness of traditional cancer therapies due to drug resistance, nontargeted delivery, and chemotherapy-associated adverse side effects has shifted attention to bioactive phytochemicals. Consequently, research efforts toward screening and identification of natural compounds with anticancer properties have increased in recent years. Marine seaweed-derived bioactive compounds, such as polyphenolic compounds, have exhibited anticancer properties. Phlorotannins (PTs), a major group of seaweed-derived polyphenolic compounds, have emerged as powerful chemopreventive and chemoprotective compounds, regulating apoptotic cell death pathways both in vitro and in vivo. In this context, this review focuses on the anticancer activity of polyphenols isolated from brown algae, with a special reference to PTs. Furthermore, we highlight the antioxidant effects of PTs and discuss how they can impact cell survival and tumor development and progression. Moreover, we discussed the potential therapeutic application of PTs as anticancer agents, having molecular mechanisms involving oxidative stress reduction. We have also discussed patents or patent applications that apply PTs as major components of antioxidant and antitumor products. With this review, researcher may gain new insights into the potential novel role of PTs, as well as uncover a novel cancer-prevention mechanism and improve human health.

show abstract

Section: Introductionmentioning

confidence: 99%

Antioxidant and chemotherapeutic efficacies of seaweed‐derived phlorotannins in cancer treatment: A review regarding novel anticancer drugs

Pradhan

2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…In addition, phlorotannins (PTs) also displayed promising antimicrobial properties [39]. According to literature [34,40,41], brown algae are a rich source of PTs with a wide range of biological activities, such as antibacterial, antifungal, antidiabetic, anticancer, and anti-inflammatory. The antibacterial capacity of PTs is largely influenced by the method of extraction, which determines the chemical structure of the phenolic compounds extracted [42].…”

Section: Introductionmentioning

confidence: 99%

Algal Phlorotannins as Novel Antibacterial Agents with Reference to the Antioxidant Modulation: Current Advances and Future Directions

et al. 2022

View full text Add to dashboard Cite

The increasing drug resistance of infectious microorganisms is considered a primary concern of global health care. The screening and identification of natural compounds with antibacterial properties have gained immense popularity in recent times. It has previously been shown that several bioactive compounds derived from marine algae exhibit antibacterial activity. Similarly, polyphenolic compounds are generally known to possess promising antibacterial capacity, among other capacities. Phlorotannins (PTs), an important group of algae-derived polyphenolic compounds, have been considered potent antibacterial agents both as single drug entities and in combination with commercially available antibacterial drugs. In this context, this article reviews the antibacterial properties of polyphenols in brown algae, with particular reference to PTs. Cell death through various molecular modes of action and the specific inhibition of biofilm formation by PTs were the key discussion of this review. The synergy between drugs was also discussed in light of the potential use of PTs as adjuvants in the pharmacological antibacterial treatment.

show abstract