Algae-based alginate biomaterial: Production and applications

Chen, Zhijie; Wei, Wei; Ni, Bing‐Jie

doi:10.1016/b978-0-323-96142-4.00004-x

Cited by 5 publications

(3 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a polysaccharide, alginate is one of the most used materials in applications such as the encapsulation of drugs, proteins, insulin, and cells in particles. Alginate particles undergo a crosslinking by either external or internal gelation and become a spherical porous hydrogel network when reacting with certain divalent cations, such as Ca 2+ [9,10]. Their water solubility, combined with their chemical affinity for divalent ions, offers the chance to process them by sustainable and reliable processing routes, such as electrospraying, which can assure accurate control and variability of the chemical-physical properties of the 3D network [11,12].…”

Section: Introductionmentioning

confidence: 99%

Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Cruz-Maya,

Schiavone,

Ferraro

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Innovations in drug delivery systems are crucial for enhancing therapeutic efficiency. Our research presents a novel approach based on using electro-fluid dynamic atomization (EFDA) to fabricate core-shell monophasic particles (CSMp) from sodium alginate blends of varying molecular weights. This study explores the morphological characteristics of these particles in relation to material properties and process conditions, highlighting their potential in drug delivery applications. A key aspect of our work is the development of a mathematical model that simulates the release kinetics of small molecules, specifically sodium diclofenac. By assessing the diffusion properties of different molecules and gel formulations through transport and rheological models, we have created a predictive tool for evaluating the efficiency of these particles in drug delivery. Our findings underscore two critical, independent parameters for optimizing drug release: the external shell thickness and the diffusivity ratios within the dual layers. This allows for precise control over the timing and intensity of the release profile. This study advances our understanding of EFDA in the fabrication of CSMp and offers promising avenues for enhancing drug delivery systems by tailoring release profiles through particle characteristic manipulation.

show abstract

Section: Introductionmentioning

confidence: 99%

Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Cruz-Maya,

Schiavone,

Ferraro

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Sodium alginate (SA) has been selected to form the 3D structure due to its recognized biocompatibility and stability using electrical forces [21]. Indeed, SA is characterized by selected patterns of molecular sequences-in particular α-L-guluronic acid (G units), ionically reactive with divalent cations (i.e., Ca 2+ , Cu 2+ , Mg 2+ , Sr 2+ )-able to promote the formation of ionic inter-chain bridges that are crucial to stabilize the droplet shape and structure during the EHDA deposition [22][23][24]. Moreover, the ionotropic crosslinking capability of SA may allow the integration of different bioactive molecules (i.e., proteins, drugs, and inorganic compounds) to improve the properties of SA-based materials [25].…”

Section: Introductionmentioning

confidence: 99%

Mineralized Microgels via Electrohydrodynamic Atomization: Optimization and In Vitro Model for Dentin–Pulp Complex

Cruz-Maya,

Altobelli,

Alvarez-Perez

et al. 2023

Gels

View full text Add to dashboard Cite

There is growing interest in the use of micro-sized hydrogels, including bioactive signals, as efficient platforms for tissue regeneration because they are able to mimic cell niche structure and selected functionalities. Herein, it is proposed to optimize bioactive composite microgels via electrohydrodynamic atomization (EHDA) to regenerate the dentin–pulp complex. The addition of disodium phosphate (Na2HPO4) salts as mineral precursors triggered an in situ reaction with divalent ions in solution, thus promoting the encapsulation of different amounts of apatite-like phases. Morphological analysis via image analysis of optical images confirmed a narrow distribution of perfectly rounded particles, with an average diameter ranging from 223 ± 18 μm to 502 ± 64 μm as a function of mineral content and process parameters used. FTIR, TEM, and EDAX analyses confirmed the formation of calcium phosphates with a characteristic Ca/P ratio close to 1.67 and a needle-like crystal shape. In vitro studies—using dental pulp stem cells (DPSCs) in crown sections of natural teeth slices—showed an increase in cell viability until 14 days, recording a decay of proliferation at 21 days, independent on the mineral amount, suggesting that differentiation is started, as confirmed by the increase of ALP activity at 14 days. In this view, mineralized microgels could be successfully used to support in vitro osteogenesis, working as an interesting model to study dental tissue regeneration.

show abstract

“…As a polysaccharide, alginate is one of the most used materials in applications such as the encapsulation of drugs, proteins, insulin, and cells in particles. Alginate particles undergo a crosslinking by either external or internal gelation and become a spherical porous hydrogel network when reacting with certain divalent cations such as Ca 2+ [9,10]. Their water Disclaimer/Publisher's Note: The statements, opinions, and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s).…”

Section: Introductionmentioning

confidence: 99%

Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Cruz-Maya,

Schiavone,

Ferraro

et al. 2023

Preprint

View full text Add to dashboard Cite

Innovations in drug delivery systems are crucial for enhancing therapeutic efficiency. Our research presents a novel approach based on Electro-fluid dynamic atomization (EFDA) to fabricate core-shell monophasic particles (CSMp) from sodium alginate blends of varying molecular weights. This study explores the morphological characteristics of these particles in relation to material properties and process conditions, highlighting their potential in drug delivery applications. A key aspect of our work is the development of a mathematical model that simulates the release kinetics of small molecules, specifically sodium diclofenac. By assessing the diffusion properties of different molecules and gel formulations through transport and rheological models, we have created a predictive tool for evaluating the efficiency of these particles in drug delivery. Our findings underscore two critical independent parameters for optimizing drug release: the external shell thickness and the diffusivity ratios within the dual layers. This allows for precise control over the timing and intensity of the release profile. The study advances our understanding of EFDA in the fabrication of CSMp and offers promising avenues for enhancing drug delivery systems by tailoring release profiles through particle characteristic manipulation.

show abstract

Algae-based alginate biomaterial: Production and applications

Cited by 5 publications

References 141 publications

Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Mineralized Microgels via Electrohydrodynamic Atomization: Optimization and In Vitro Model for Dentin–Pulp Complex

Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Contact Info

Product

Resources

About