Alfuzosin to Relieve Ureteral Stent Discomfort: A Randomized Placebo-Controlled Study

Management of JJ stent-related symptoms

“…Sev eral phar ma ceu ti cal stud ies [3][4][5][6][7][8][9][10][11] and meta-anal y ses 4,5 dem on strated a con sis tent ben e fi cial ef fect of al phablockers in pa tients with in dwell ing ureteral JJ stents. The ad min is tra tion of a se lec tive al pha-blocker, such as alfuzosin or tamsulosin, im proved stent re lated uri nary symp toms, es pe cially pain.…”

“…The au thors ad min is tered the USSQ four weeks af ter stent in ser tion and con cluded that alfuzosin im proved JJ stent re lated uri nary symp toms and pain, while sex ual func tion and gen eral health were better pre served. In a pro spec tive, ran dom ized, pla cebo con trolled study of 55 pa tients with in dwell ing ureteral stents af ter ureteroscopy, Beddingfield et al 6 re ported that alfuzosin mark edly de creased the pain as so ci ated with ureteral stents but had lit tle ef fect on uri nary symptoms in gen eral. They ad min is tered the USSQ pre op er atively and three days af ter the pro ce dure, which may have been too early.…”