Alfentanil pharmacokinetics in patients undergoing abdominal aortic surgery

Abstract

The pharmacokinetics of alfentanil, 300 I~g" kg -I IV, were determined in patients undergoing elective abdominal aortic reconstruction. The mean age ( • SD)

Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems

“…In both populations, the variation of the PE around the MDPE (Wobble) in the Scott parameters (weight adjusted or not) was lower compared with those by Hudson, 16 Mertens, 28 Lemmens, 17 and Maitre. 18 The Wobble was also affected by the mode of administration with the parameters by Scott, 20 Fragen, 15 Maitre, 18 and Mertens.…”

“…In the infusion data (green boxes in Fig. 2), the MDAPE with the Scott parameters was significantly lower than with the parameters by Hudson, 16 Mertens, 28 Lemmens, 17 and Shafer (P,0.05). MDAPE values were 22.3% (Scott), 20 26.5% (Fragen), 15 26.5% (Scott weight adjusted), and 41% (Maitre).…”

“…MDAPE values were 22.3% (Scott), 20 26.5% (Fragen), 15 26.5% (Scott weight adjusted), and 41% (Maitre). 18 The log accuracy was significantly lower compared with Hudson, 16 Lemmens, 17 and Shafer (P,0.05).…”

“…3). In both data sets MDPE and log bias of the parameter sets of Scott, 20 Scott weight adjusted and Shafer showed tendency to overpredict whereas those of Maitre, 18 Hudson, 16 and Mertens 28 showed tendency to underpredict the measured concentration (Fig. 3).…”

“…for the Hudson 16 and Shafer parameters was 12 (0.8, 45) and 9 (7, 12), respectively. In bolus application, the Divergence values were 18 (2, 31) and 7 (5, 10), respectively (Fig.…”