Aleurites moluccana and its main active ingredient, the flavonoid 2″-O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice

Quintão, Nara Lins Meira; Antonialli, Carla S.; Silva, Gislaine F. da; Rocha, Lilian W.; Souza, Márcia María de; Malheiros, Ângela; Meyre‐Silva, Christiane; Lucinda-Silva, Ruth Meri; Bresolin, Tania Mari Bellé; Filho, Valdir Cechinel

doi:10.1016/j.pbb.2012.05.005

Cited by 26 publications

(16 citation statements)

References 39 publications

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“…The 25‐MHA (10 mg/kg, i.p) was coadministered with the gabapentin to observe the synergistic antinociceptive effect according to the previously reported methods with necessary modification (Quintão et al, ). The gabapentin is three‐substituted g‐aminobutyric acid (GABA) derivatives; however, it does not exhibit any affinity for the GABA receptors.…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, to explore the chronic antinociceptive effect of 25‐MHA (10 mg/kg, i.p), the readings were taken 4 h after the CFA injection from Days 0 to 6. The dose of 25‐MHA (10 mg/kg, i.p) was skipped at Day 5 to assess the possible tolerance effect according to the previously described method (Quintão et al, ). Mechanical hyperalgesia was evaluated before and after the initiation of the treatment.…”

Section: Methodsmentioning

confidence: 99%

“…Following the administration of CFA, the paw thickness was administered 2, 4, and 6 h after the CFA administration for the acute effect, whereas paw thickness was also measured from 0 to 6 days for the chronic effect. 25‐MHA (10 mg/kg, i.p) is not administered at Day 5 to evaluate the possible tolerance effect (Quintão et al, ). However, in case of carrageenan‐induced paw edema, all the four groups were pretreated 1 h before the administration of carrageenan, and the paw edema was measured 4 h after the carrageenan injection.…”

Section: Methodsmentioning

confidence: 99%

“…To assess the possible mechanism, the 25‐MHA (10 mg/kg, i.p) was coadministered with various drugs such as gabapentin, piroxicam, and tramadol. The combined as well as the individual antinociceptive effect was determined following administration of carrageenan (i.pl) as described previously with slight modification (Gilron et al, ; Quintão et al, ). Gabapentin produces its pharmacological effect by interacting with Ca V α 2 δ, a novel and high affinity drug binding site located particularly at synapses.…”

Section: Methodsmentioning

confidence: 99%

“…The pain produced during the process of inflammation is triggered by various mediators that sensitise the nociceptive nerve endings. The activation of the primary sensory neurons is the main triggering factor in inflammatory pain that leads to hyperalgesia and allodynia (de Lima et al, ; Khan, Shehzad, Chun, & Kim, ; Quintão et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive properties of 25‐methoxy hispidol A, a triterpinoid isolated from Poncirus trifoliata (Rutaceae) through inhibition of NF‐κB signalling in mice

Khan

Ullah

Afridi

et al. 2018

Phytotherapy Research

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The 25-methoxy hispidol A (25-MHA) is a triterpenoid, isolated from the immature fruit of Poncirus trifoliata (Rutaceae). The pretreatment with 25-MHA markedly (p < 0.001) attenuated the formalin-induced biphasic responses as well as acetic acid-induced writhing responses. The intraperitoneal administration of 25-MHA significantly attenuated the mechanical hyperalgesia (p < 0.001) and allodynia (p < 0.05). Similarly, 25-MHA also significantly attenuated (p < 0.001) complete Freund's adjuvant (CFA)-induced paw edema in mice. The 25-MHA treatment significantly attenuated the production of nuclear kappa B (NF-κB) (p65 nuclear subunit). The cytokines are the important mediators of inflammation and pain; however, treatment with 25-MHA exhibited significant inhibition (p < 0.001) on the mRNA expression levels of various inflammatory mediators. The 25-MHA administration also significantly enhanced antioxidant enzymes (p < 0.001) and inhibited the oxidative stress markers. The current study indicates that 25-MHA significantly (p < 0.001) inhibited the nitric oxide (NO) in mice plasma. Similarly, the haematoxylin and eosin (H&E) staining shows that 25-MHA administration significantly inhibited the inflammatory process in the mice paw tissue compared with the CFA-treated group. The 25-MHA treatment did not exhibited any toxicity on the liver, kidney, muscles strength, and motor co-ordination in mice. The 25-MHA was coadministered with the various drugs such as tramadol, piroxicam, and gabapentin to observe the synergistic effect.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antinociceptive properties of 25‐methoxy hispidol A, a triterpinoid isolated from Poncirus trifoliata (Rutaceae) through inhibition of NF‐κB signalling in mice

Khan

Ullah

Afridi

et al. 2018

Phytotherapy Research

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Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain

Kwankaew

Okuda

Aye-Mon

et al. 2021

European Journal of Pain

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Background: Neuropathic pain (NeP) medications have several side effects that affect NeP patients' quality of life. Betanin, the most common betacyanin pigment, has been shown to have potent antioxidant and anti-inflammatory properties in vivo; thus, it has potential as a healthcare treatment. In this study, we focused on betanin (red beetroot extract) as a potential therapy for NeP. Methods: Mice model of NeP were made by chronic constriction injury (CCI), and the development of mechanical hypersensitivity was confirmed using the von Frey test. Motor coordination and locomotor activity were assessed using open field tests and rotarod tests, respectively. The expression level of glial markers in the spinal cords was analyzed by immunostaining. The direct effects of betanin on microglial cells were investigated using primary cultured microglial cells. Results: In CCI model mice, repeated betanin treatment, both intraperitoneally and orally, attenuated developing mechanical hypersensitivity in a dose-dependent manner without impairing motor coordination. Betanin treatment also attenuated mechanical hypersensitivity that had developed and prevented the onset of mechanical hypersensitivity in CCI mice. Microglial activation in the spinal cord is known to play a key role in the development of NeP; betanin treatment reduced CCI-induced microglial activation in the spinal cord of model mice. Moreover, in primary microglia cultured cells, the activation of microglia by lipopolysaccharide application was suppressed by betanin treatment. Conclusion: Betanin treatment appears to ameliorate mechanical hypersensitivity related to CCI-induced NeP in mice by inhibiting microglial activation. Significance: This article supports findings of the effect of betanin on NeP and provides a potential therapeutic candidate for NeP. Furthermore, elucidating the underlying mechanism of the effect of betanin on microglial activation could assist the development of new treatments for chronic pain. How to cite this article: Kwankaew N, Okuda H, Aye-Mon A, et al. Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain.

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Curcuminoids-enriched extract and its cyclodextrin inclusion complexes ameliorates arthritis in complete Freund’s adjuvant-induced arthritic mice via modulation of inflammatory biomarkers and suppression of oxidative stress markers

Saleem,

Chauhdary,

Bakhtawar

et al. 2023

Inflammopharmacol

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Aleurites moluccana and its main active ingredient, the flavonoid 2″-O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice

Cited by 26 publications

References 39 publications

Antinociceptive properties of 25‐methoxy hispidol A, a triterpinoid isolated from Poncirus trifoliata (Rutaceae) through inhibition of NF‐κB signalling in mice

Antinociceptive properties of 25‐methoxy hispidol A, a triterpinoid isolated from Poncirus trifoliata (Rutaceae) through inhibition of NF‐κB signalling in mice

Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain

Curcuminoids-enriched extract and its cyclodextrin inclusion complexes ameliorates arthritis in complete Freund’s adjuvant-induced arthritic mice via modulation of inflammatory biomarkers and suppression of oxidative stress markers

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